Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration
Daniel J. Nolan,Michael Ginsberg,Edo Israely,Brisa Palikuqi,Michael G. Poulos,Daylon James,Bi-Sen Ding,William Schachterle,Ying Liu,Zev Rosenwaks,Jason M. Butler,Jenny Xiang,Arash Rafii,Arash Rafii,Koji Shido,Sina Y. Rabbany,Sina Y. Rabbany,Olivier Elemento,Shahin Rafii +18 more
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TLDR
It is shown that clusters of transcription factors, angiocrine growth factors, adhesion molecules, and chemokines are expressed in unique combinations by ECs of each organ.About:
This article is published in Developmental Cell.The article was published on 2013-07-29 and is currently open access. It has received 508 citations till now. The article focuses on the topics: Angiocrine growth factors & Transplantation.read more
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A molecular atlas of cell types and zonation in the brain vasculature
Michael Vanlandewijck,Michael Vanlandewijck,Liqun He,Maarj A. Andaloussi Mäe,Johanna Andrae,Koji Ando,Francesca Del Gaudio,Khayrun Nahar,Thibaud Lebouvier,Thibaud Lebouvier,Bàrbara Laviña,Leonor Gouveia,Ying Sun,Elisabeth Raschperger,Markus Räsänen,Yvette Zarb,Naoki Mochizuki,Annika Keller,Urban Lendahl,Christer Betsholtz,Christer Betsholtz +20 more
TL;DR: The transcriptional basis of the gradual phenotypic change along the arteriovenous axis is uncovered and unexpected cell type differences are revealed: a seamless continuum for endothelial cells versus a punctuated continuum for mural cells.
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Hematopoietic stem cell niche maintenance during homeostasis and regeneration
TL;DR: Recently discovered intrinsic mechanisms, microenvironmental interactions and communication with surrounding cells involved in HSC regulation, during homeostasis and in regeneration after injury are highlighted and their implications for regenerative therapy are discussed.
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Angiocrine functions of organ-specific endothelial cells
TL;DR: Uncovering the mechanisms by which organotypic endothelium distributes physiological levels of angiocrine factors both spatially and temporally will lay the foundation for clinical trials that promote organ repair without scarring.
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Single-Cell Transcriptome Atlas of Murine Endothelial Cells
Joanna Kalucka,Laura P.M.H. de Rooij,Jermaine Goveia,Katerina Rohlenova,Sébastien J. Dumas,Elda Meta,Nadine V. Conchinha,Federico Taverna,Laure-Anne Teuwen,Koen Veys,Melissa García-Caballero,Shawez Khan,Vincent Geldhof,Liliana Sokol,Rongyuan Chen,Lucas Treps,Mila Borri,Pauline de Zeeuw,Charlotte Dubois,Tobias K. Karakach,Kim D. Falkenberg,Magdalena Parys,Xiangke Yin,Stefan Vinckier,Yuxiang Du,Robert A. Fenton,Luc Schoonjans,Luc Schoonjans,Mieke Dewerchin,Guy Eelen,Bernard Thienpont,Lin Lin,Lars Bolund,Xuri Li,Yonglun Luo,Peter Carmeliet,Peter Carmeliet +36 more
TL;DR: An atlas of >32,000 single-EC transcriptomes from 11 mouse tissues was constructed and 78 EC subclusters were identified, including Aqp7+ intestinal capillaries and angiogenic ECs in healthy tissues and provides a powerful discovery tool and resource value.
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Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis
Joo-Hyeon Lee,Joo-Hyeon Lee,Dong Ha Bhang,Alexander M. Beede,Alexander M. Beede,Tian Lian Huang,Barry R. Stripp,Kenneth D. Bloch,Amy J. Wagers,Amy J. Wagers,Amy J. Wagers,Yu-Hua Tseng,Sandra Ryeom,Carla F. Kim,Carla F. Kim +14 more
TL;DR: Gain- and loss-of-function experiments showed that BMP4-Bmpr1a signaling triggers calcineurin/NFATc1-dependent expression of thrombospondin-1 (Tsp1) in lung endothelial cells to drive alveolar lineage-specific BASC differentiation, elucidate a pathway that may be a critical target in lung diseases and provide tools to understand the mechanisms of respiratory diseases at the single-cell level.
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Endothelial and perivascular cells maintain haematopoietic stem cells
TL;DR: HSCs reside in a perivascular niche in which multiple cell types express factors that promote HSC maintenance, and were depleted from bone marrow when Scf was deleted from endothelial cells or leptin receptor (Lepr)-expressing periv vascular stromal cells.
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Astrocytes induce blood–brain barrier properties in endothelial cells
Robert C. Janzer,Martin Raff +1 more
TL;DR: Direct evidence is provided that astrocytes are capable of inducing blood–brain barrier properties in non-neural endothelial cells in vivo.
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Phenotypic Heterogeneity of the Endothelium: I. Structure, Function, and Mechanisms
TL;DR: An historical perspective of the understanding of endothelial heterogeneity is provided, the scope of phenotypic diversity across the vascular tree is discussed, and the proximate and evolutionary mechanisms of endothelium heterogeneity are addressed.
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Induction of Pancreatic Differentiation by Signals from Blood Vessels
TL;DR: A role for blood vessels as a source of developmental signals during pancreatic organogenesis is demonstrated and results indicate that vessels not only provide metabolic sustenance, but also provide inductive signals for organ development.
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Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches
Lei Ding,Sean J. Morrison +1 more
TL;DR: Assessment of the physiological sources of the chemokine CXCL12 for HSC and restricted progenitor maintenance shows that Cxcl12 was primarily expressed by perivascular stromal cells and, at lower levels, by endothelial cells, osteoblasts and some haematopoietic cells.