M
Michael Levitt
Researcher at Stanford University
Publications - 422
Citations - 43139
Michael Levitt is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 99, co-authored 349 publications receiving 41423 citations. Previous affiliations of Michael Levitt include Laboratory of Molecular Biology & Bar-Ilan University.
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Journal ArticleDOI
Theoretical studies of enzymic reactions: Dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme
TL;DR: Electrostatic stabilization is an important factor in increasing the rate of the reaction step that leads to the formation of the carbonium ion intermediate, found in the cleavage of a glycosidic bond by lysozyme.
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Conformations of immunoglobulin hypervariable regions.
Cyrus Chothia,Cyrus Chothia,Arthur M. Lesk,Anna Tramontano,Michael Levitt,Michael Levitt,Sandra J. Smith-Gill,Gillian M. Air,Steven Sheriff,Steven Sheriff,Eduardo A. Padlan,David R. Davies,W.R. Tulip,Peter M. Colman,Silvia Spinelli,Pedro M. Alzari,Roberto J. Poljak +16 more
TL;DR: There is a small repertoire of main-chain conformations for at least five of the six hypervariable regions of antibodies, and that the particular conformation adopted is determined by a few key conserved residues.
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A humanized antibody that binds to the interleukin 2 receptor.
Cary L. Queen,William P. Schneider,Harold E. Selick,Philip W. Payne,Nicholas F. Landolfi,James F. Duncan,Nevenka M. Avdalovic,Michael Levitt,Richard P. Junghans,Thomas A. Waldmann +9 more
TL;DR: A "humanized" antibody is constructed by combining the complementarity-determining regions (CDRs) of the anti-Tac antibody with human framework and constant regions and has an affinity for p55 of 3 x 10(9) M-1, about 1/3 that of murine anti- Tac.
Journal ArticleDOI
Structural patterns in globular proteins
Michael Levitt,Cyrus Chothia +1 more
TL;DR: A simple diagrammatic representation has been used to show the arrangement of α helices and β sheets in 31 globular proteins, which are classified into four clearly separated classes.
Journal ArticleDOI
A simplified representation of protein conformations for rapid simulation of protein folding
Michael Levitt,Michael Levitt +1 more
TL;DR: This work shows how the concept of time-averaged forces can be used to simplify conformafional energy calculations on globular proteins and shows that the simplifications work well in representing the stable native conformation of this globular protein.