M
Michael McClelland
Researcher at University of California, Irvine
Publications - 376
Citations - 29109
Michael McClelland is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Salmonella enterica & Salmonella. The author has an hindex of 79, co-authored 372 publications receiving 27627 citations. Previous affiliations of Michael McClelland include University of Illinois at Chicago & University of Georgia.
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Journal ArticleDOI
Recognition sequences of Type II restriction systems are constrained by the G+C content of host genomes
TL;DR: Evidence is presented that most Type II "restriction systems" are indeed involved in phage restriction and that the recognition sequences of Type II restriction systems are correlated with the G + C content of the host bacterial DNA.
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PypeR, A Python Package for Using R in Python
TL;DR: PypeR, a Python package which allows the R language to be called in Python using the pipe communication method, gains flexibility in sub-process controls, memory control, and portability across popular operating system platforms.
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High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with ∼240-Fold Higher Drug Concentration in Urine than Serum
Zhongbo Liu,Noriko N. Yokoyama,Christopher A. Blair,Xuesen Li,Daina Avizonis,Xue-Ru Wu,Edward Uchio,Ramy F. Youssef,Michael McClelland,Michael Pollak,Xiaolin Zi +10 more
TL;DR: The basis of the unusual sensitivity of this model to metformin is investigated, and it is observed that following oral dosing, urothelium is exposed to drug concentrations via the urine that are approximately 240-fold higher than those in the circulation.
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Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH
Sangeeta Chakraborty,Lin Liu,Liam F. Fitzsimmons,Steffen Porwollik,Ju-Sim Kim,Prerak T. Desai,Michael McClelland,Andrés Vázquez-Torres,Andrés Vázquez-Torres +8 more
TL;DR: It is demonstrated that NOX2 collapses the ΔpH of intracellular Salmonella Typhimurium, leading to oxidative damage of cell envelope proteins, and primordial metabolic pathways, already present in bacteria before aerobic respiration evolved, offer a solution to the stress ROS exert on molecular targets at the bacterial cell envelope.
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SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome.
Liam F. Fitzsimmons,Lin Liu,Sashi Kant,Ju-Sim Kim,James Karl A Till,Jessica Jones-Carson,Steffen Porwollik,Michael McClelland,Andrés Vázquez-Torres,Andrés Vázquez-Torres +9 more
TL;DR: The biochemical and functional characterization of a spoT-Δctd mutant Salmonella strain encoding a SpoT protein that lacks the C-terminal regulatory elements collectively referred to as “ctd.”