M
Michael McClelland
Researcher at University of California, Irvine
Publications - 376
Citations - 29109
Michael McClelland is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Salmonella enterica & Salmonella. The author has an hindex of 79, co-authored 372 publications receiving 27627 citations. Previous affiliations of Michael McClelland include University of Illinois at Chicago & University of Georgia.
Papers
More filters
Journal ArticleDOI
The intestinal fatty acid propionate inhibits Salmonella invasion through the post‐translational control of HilD
Chien Che Hung,Cherilyn D. Garner,James M. Slauch,Zachary W. Dwyer,Sara D. Lawhon,Jonathan G. Frye,Michael McClelland,Brian M. M. Ahmer,Craig Altier +8 more
TL;DR: A mechanism of control of Salmonella virulence in which HilD is post‐translationally modified using the high‐energy intermediate propionyl‐CoA is suggested, suggesting modification of HilD with subsequent degradation as the means of action.
Journal ArticleDOI
Evolutionary Genomics of Salmonella enterica Subspecies
Prerak T. Desai,Steffen Porwollik,Fred Long,Pui Cheng,Aye Wollam,Sandra W. Clifton,George M. Weinstock,Michael McClelland +7 more
TL;DR: Analysis of nonsynonymous-to-synonymous substitution rates indicated that the more-recently acquired regions in S. enterica are undergoing faster fixation rates than the rest of the genome, indicating that recently acquired AT-rich regions, which often encode virulence functions, are under ongoing selection to maintain their high AT content.
Journal ArticleDOI
Defined Single-Gene and Multi-Gene Deletion Mutant Collections in Salmonella enterica sv Typhimurium
Steffen Porwollik,Carlos A. Santiviago,Pui Cheng,Fred Long,Prerak T. Desai,Jennifer Fredlund,Shabarinath Srikumar,Cecilia A. Silva,Weiping Chu,Xin Chen,Rocío Canals,M. Megan Reynolds,Lydia M. Bogomolnaya,Christine A. Shields,Ping Cui,Jinbai Guo,Yi Zheng,Tiana Endicott-Yazdani,Hee Jeong Yang,Aimee Maple,Yury Ragoza,Carlos J. Blondel,Camila Valenzuela,Helene Andrews-Polymenis,Michael McClelland +24 more
TL;DR: Together, the libraries allow hierarchical screening of MGDs for different phenotypic followed by screening of SGDs within the target MGD regions.
Journal ArticleDOI
Asymmetrical distribution of CpG in an ‘average’ mammalian gene
Michael McClelland,Robert Ivarie +1 more
TL;DR: The frequency and distribution of the rare dinucleotide CpG was examined in 15 mammalian genes and CpGs were asymmetrically distributed in sequences flanking the genes, reflecting the role of 5-methylcytosine in gene expression.
Journal ArticleDOI
Identification and sequence analysis of a 27-kilobase chromosomal fragment containing a Salmonella pathogenicity island located at 92 minutes on the chromosome map of Salmonella enterica serovar typhimurium LT2.
Kwong Kwok Wong,Michael McClelland,Lisa C. Stillwell,Ellen C. Sisk,Sarah J. Thurston,Jeffrey D. Saffer +5 more
TL;DR: It is suggested that SPI-4 is needed for intramacrophage survival, which is the fourth Salmonella pathogenicity island to be identified and likely to carry a type I secretion system involved in toxin secretion.