M
Michael McClelland
Researcher at University of California, Irvine
Publications - 376
Citations - 29109
Michael McClelland is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Salmonella enterica & Salmonella. The author has an hindex of 79, co-authored 372 publications receiving 27627 citations. Previous affiliations of Michael McClelland include University of Illinois at Chicago & University of Georgia.
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Journal ArticleDOI
Web-based visualization tools for bacterial genome alignments
Liliana Florea,Cathy Riemer,Scott Schwartz,Zheng Zhang,Nikola Stojanovic,Nikola Stojanovic,Webb Miller,Michael McClelland +7 more
TL;DR: These web-based tools revealed that rffH, a gene involved in enterobacterial common antigen (ECA) biosynthesis, is partly deleted in one of the genomes, and were used to show that this deletion occurs sporadically in some strains of some serovars of S.enterica subspecies I but not in any strains tested from six other subspecies.
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Use of a promiscuous, constitutively-active bacterial enhancer-binding protein to define the σ54 (RpoN) regulon of Salmonella Typhimurium LT2
David J. Samuels,Jonathan G. Frye,Steffen Porwollik,Michael McClelland,Jan Mrázek,Timothy R. Hoover,Anna C. Karls +6 more
TL;DR: This work assesses the ability of a promiscuous, constitutively-active bEBP—the AAA+ ATPase domain of DctD from Sinorhizobium meliloti—to activate transcription from all σ54-dependent promoters for the characterization of the ρ54 regulon of Salmonella Typhimurium LT2.
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The frequency and distribution of methylatable DNA sequences in leguminous plant protein coding genes
TL;DR: An analysis of the distribution of di- and trinucleotides across functionally classified regions of genes showed CpG to be asymmetrically distributed, which may reflect a methylation-mediated regulatory role for this region in some legume genes.
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Import of Aspartate and Malate by DcuABC Drives H2/Fumarate Respiration to Promote Initial Salmonella Gut-Lumen Colonization in Mice
Bidong D. Nguyen,V Miguelangel Cuenca,Johannes Hartl,Ersin Gül,Rebekka Bauer,Susanne Meile,Joel Rüthi,Céline Margot,Laura Heeb,Franziska Besser,Pau Pérez Escriva,Céline Fetz,Markus Furter,Leanid Laganenka,Philipp J. Keller,Lea Fuchs,Matthias Christen,Steffen Porwollik,Michael McClelland,Julia A. Vorholt,Uwe Sauer,Shinichi Sunagawa,Beat Christen,Wolf-Dietrich Hardt +23 more
TL;DR: Transposon sequencing analysis along the colonization trajectory of S. Typhimurium implicates the C4-dicarboxylate antiporter DcuABC in early murine gut colonization and allows S. Typhoon to harvest energy by H2/fumarate respiration in the microbiota-colonized gut.
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Solid tumors provide niche-specific conditions that lead to preferential growth of Salmonella
Cecilia A. Silva-Valenzuela,Prerak T. Desai,Roberto C. Molina-Quiroz,David Pezoa,Yong Zhang,Steffen Porwollik,Ming Zhao,Robert M. Hoffman,Inés Contreras,Carlos A. Santiviago,Michael McClelland +10 more
TL;DR: A high-throughput screening of single-gene deletion mutants of S. Typhimurium in an orthotopic, syngeneic murine mammary model of breast cancer shows that the chemotaxis gene cheY and the motility genes motAB confer an advantage for colonization of Salmonella within Orthotopic syngenesic breast tumors.