M
Michael McClelland
Researcher at University of California, Irvine
Publications - 376
Citations - 29109
Michael McClelland is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Salmonella enterica & Salmonella. The author has an hindex of 79, co-authored 372 publications receiving 27627 citations. Previous affiliations of Michael McClelland include University of Illinois at Chicago & University of Georgia.
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Journal ArticleDOI
Comparison of Sample Sequences of the Salmonella typhi Genome to the Sequence of the Complete Escherichia coli K-12 Genome
TL;DR: Raw sequence data representing the majority of a bacterial genome can be obtained at a tiny fraction of the cost of a completed sequence, to demonstrate the utility of such a resource, 870 single-stranded M13 clones were sequenced from a shotgun library of the Salmonella typhi Ty2 genome.
Book ChapterDOI
Arbitrary primed PCR fingerprinting of RNA applied to mapping differentially expressed genes.
TL;DR: Differential gene expression between various tissues and developmental stages or between cells in vitro under different growth conditions can be rapidly and efficiently compared using the RAP fingerprinting method, yielding highly reproducible fingerprints that are tissue-specific or growth condition-specific.
Journal ArticleDOI
Identification of Specific Gene Sequences Conserved in Contemporary Epidemic Strains of Salmonella enterica
Min-Su Kang,Thomas E. Besser,Dale D. Hancock,Steffen Porwollik,Michael McClelland,Douglas R. Call +5 more
TL;DR: Epidemic strains of S. enterica had specific genes and gene regions that were shared by isolates of the same subtype, and may be associated with the presence of fitness-associated genetic factors in addition to their antimicrobial resistance genes.
Journal ArticleDOI
DksA-Dependent Transcriptional Regulation in Salmonella Experiencing Nitrosative Stress
Matthew A. Crawford,Calvin A. Henard,Timothy Tapscott,Steffen Porwollik,Michael McClelland,Andrés Vázquez-Torres +5 more
TL;DR: It is demonstrated that DksA mediates global adaptation to nitrosative stress in Salmonella and provides unique insight into a novel regulatory mechanism by which cysteine biosynthesis is controlled in response to reactive oxygen and nitrogen species.
Journal ArticleDOI
"Promoter array" studies identify cohorts of genes directly regulated by methylation, copy number change, or transcription factor binding in human cancer cells.
Yipeng Wang,Jun Hayakawa,Fred Long,Qiuju Yu,Ann H. Cho,Gaelle Rondeau,John Welsh,Shalu Mittal,Ian de Belle,Eileen D. Adamson,Michael McClelland,Dan Mercola +11 more
TL;DR: The vast majority of genes that appear to be both differentially methylated and differentially regulated between prostate epithelial and cancer cell lines are novel methylation targets, including PAK6, RAD50, TLX3, PIR51, MAP2K5, INSR, FBN1, GG2‐1, representing a rich new source of candidate genes to study the role of DNA methylation in prostate tumors.