M
Michael Oelgeschläger
Researcher at Federal Institute for Risk Assessment
Publications - 22
Citations - 441
Michael Oelgeschläger is an academic researcher from Federal Institute for Risk Assessment. The author has contributed to research in topics: Embryonic stem cell & Cancer. The author has an hindex of 10, co-authored 22 publications receiving 342 citations.
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Journal ArticleDOI
Alternatives to animal testing: current status and future perspectives
Manfred Liebsch,Barbara Grune,Andrea Seiler,Daniel Butzke,Michael Oelgeschläger,Ralph Pirow,Sarah Adler,Christian Riebeling,Andreas Luch +8 more
TL;DR: An overview of the achievements and current tasks, as well as a vision of the future to be addressed by ZEBET@BfR in the years to come is outlined in the present paper.
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Neural differentiation of mouse embryonic stem cells as a tool to assess developmental neurotoxicity in vitro.
Anke Visan,Katrin Hayess,Dana Sittner,Elena E. Pohl,Elena E. Pohl,Christian Riebeling,Birgitta Slawik,Konrad Gulich,Michael Oelgeschläger,Andreas Luch,Andrea Seiler +10 more
TL;DR: The current study shows that D3 mESCs differentiate efficiently into neural cells involving a neurosphere-like state and that this system is suitable to detect adverse effects of neurodevelopmental toxicants.
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Regulatory toxicology in the twenty-first century: challenges, perspectives and possible solutions.
Tewes Tralau,Michael Oelgeschläger,Rainer Gürtler,Gerhard Heinemeyer,Matthias Herzler,Thomas Höfer,Heike Itter,Thomas Kuhl,Nikola Lange,Nicole Lorenz,Christine Müller-Graf,Ulrike Pabel,Ralph Pirow,Vera Ritz,Helmut Schafft,Heiko Schneider,Thomas G. Schulz,David M. Schumacher,S. Zellmer,Gaby Fleur-Böl,Matthias Greiner,Monika Lahrssen-Wiederholt,Alfonso Lampen,Andreas Luch,Gilbert Schönfelder,Roland Solecki,Reiner Wittkowski,Andreas Hensel +27 more
TL;DR: This document summarizes key aspects of this debate in the light of the European “regulatory status quo”, while elucidating new perspectives for regulatory toxicity testing.
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Caenorhabditis elegans As a Promising Alternative Model for Environmental Chemical Mixture Effect Assessment-A Comparative Study.
Paul Wittkowski,Philip Marx-Stoelting,Norman Violet,Verena Fetz,Franziska Schwarz,Michael Oelgeschläger,Gilbert Schönfelder,Gilbert Schönfelder,Silvia Vogl +8 more
TL;DR: C. elegans may be an appropriate model for mixture toxicity testing at least within a first step to identify and prioritize relevant mixtures for further testing, and well-defined concentration-response relationships provide a very good basis for the prediction of mixture effects.
Journal ArticleDOI
Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology - Evolution versus revolution.
T. Burgdorf,Aldert H. Piersma,Robert Landsiedel,R Clewell,Nicole Kleinstreuer,Michael Oelgeschläger,Bertrand Desprez,Anne S. Kienhuis,P Bos,R de Vries,L de Wit,T Seidle,Jesper Scheel,Gilbert Schönfelder,Gilbert Schönfelder,J. van Benthem,Anne Marie Vinggaard,Chantra Eskes,Janine Ezendam +18 more
TL;DR: A more comprehensive evaluation of biological relevance, scientific validity and regulatory purpose of new test methods and assessment strategies together with case studies that provide practical experience with new approaches were discussed as essential steps to build up the necessary confidence to facilitate regulatory acceptance.