M
Michael Q. Zhang
Researcher at Tsinghua University
Publications - 396
Citations - 46412
Michael Q. Zhang is an academic researcher from Tsinghua University. The author has contributed to research in topics: Gene & Chromatin. The author has an hindex of 93, co-authored 378 publications receiving 42008 citations. Previous affiliations of Michael Q. Zhang include Chinese Academy of Sciences & Peking Union Medical College Hospital.
Papers
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Journal ArticleDOI
Engineering EMT using 3D micro-scaffold to promote hepatic functions for drug hepatotoxicity evaluation.
Jingyu Wang,Fengling Chen,Longwei Liu,Chunxiao Qi,Bingjie Wang,Xiaojun Yan,Chenyu Huang,Wei Hou,Michael Q. Zhang,Yang Chen,Yanan Du +10 more
TL;DR: It is hypothesize that 3D culture enhances hepatic functions through regulating the EMT status, and regulation of EMT as a vital consideration in designing 3D hepatocyte culture configuration.
Proceedings ArticleDOI
Cluster, function and promoter: analysis of yeast expression array.
J. Zhu,Michael Q. Zhang +1 more
TL;DR: This study explored the possible ways to analyze the large-scale gene expression data and developed a largest-first algorithm, which provide a mechanism for quality control on clusters.
Journal ArticleDOI
A highly efficient and effective motif discovery method for ChIP-seq/ChIP-chip data using positional information
TL;DR: A new k-mer occurrence model is proposed to reflect the fact that functional DNA k-mers often cluster around ChIP peak summits and is much faster than several other methods for large sample sizes and is more robust against noises in ChIP data than available methods.
Journal ArticleDOI
Dual-specificity splice sites function alternatively as 5′ and 3′ splice sites
TL;DR: A class of splice sites that are conceptually similar to a pair of mutually exclusive exons separated by a zero-length intron are described, which exist in human and mouse and possibly in other vertebrate species, although most sites are not conserved.
Journal ArticleDOI
The landscape of RNA polymerase II–associated chromatin interactions in prostate cancer
Susmita G. Ramanand,Yong Chen,Yong Chen,Jiapei Yuan,Kelly Daescu,Maryou B K Lambros,Kathleen E. Houlahan,Suzanne Carreira,Wei Yuan,Guem Hee Baek,Adam Sharp,Alec Paschalis,Mohammed Kanchwala,Yunpeng Gao,Adam Aslam,Nida Safdar,Xiaowei Zhan,Ganesh V. Raj,Chao Xing,Paul C. Boutros,Johann S. de Bono,Michael Q. Zhang,Michael Q. Zhang,Ram Shankar Mani +23 more
TL;DR: It is shown that AR locus amplification contributes to the transcriptional up-regulation of AR gene by increasing the total number of chromatin interaction modules comprising of the AR gene and its distal enhancer.