M
Michael Q. Zhang
Researcher at Tsinghua University
Publications - 396
Citations - 46412
Michael Q. Zhang is an academic researcher from Tsinghua University. The author has contributed to research in topics: Gene & Chromatin. The author has an hindex of 93, co-authored 378 publications receiving 42008 citations. Previous affiliations of Michael Q. Zhang include Chinese Academy of Sciences & Peking Union Medical College Hospital.
Papers
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Journal ArticleDOI
The effects of carbon dioxide and temperature on microRNA expression in Arabidopsis development
Patrick May,Will Liao,Will Liao,Yijin Wu,Bin Shuai,W. Richard McCombie,Michael Q. Zhang,Michael Q. Zhang,Qiong A. Liu +8 more
TL;DR: It is demonstrated that both CO2 and temperature alter microRNA expression to affect Arabidopsis growth and development, and miR156/157- andmiR172-regulated transcriptional network might underlie the onset of early flowering induced by increasing CO2.
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Identification of Human Gene Core Promoters in Silico
TL;DR: Using positional dependent 5-tuple measures, a quadratic discriminant analysis (QDA) method has been implemented in a new program-CorePromoter, and experiments indicate that when given a 1- to 2-kb extended promoter, CorePromoter will correctly localize the TSS to a 100-bp interval approximately 60% of the time.
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Activity-dependent FUS dysregulation disrupts synaptic homeostasis
Chantelle F. Sephton,Amy A. Tang,Ashwinikumar Kulkarni,James E. West,Mieu Brooks,Jeremy J. Stubblefield,Yun Liu,Michael Q. Zhang,Carla B. Green,Kimberly M. Huber,Eric J. Huang,Joachim Herz,Gang Yu +12 more
TL;DR: Novel transgenic mouse models expressing low levels of wild-type and mutant human FUS, both of which recapitulate aspects of the human diseases are generated, and a profound difference in the underlying mechanisms by which missense mutation and wild- type overexpression cause disease is found.
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Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4
Liang Li,Jing Tang,Baohua Zhang,Wen Yang,Miyang Liu-Gao,Ruoyu Wang,Yexiong Tan,Jianling Fan,Yanxin Chang,Jing Fu,Feng Jiang,Caiyang Chen,Yingcheng Yang,Jin Gu,Dingming Wu,Lin-Na Guo,Dan Cao,Hengyu Li,Guangwen Cao,Meng-Chao Wu,Michael Q. Zhang,Lei Chen,Hongyang Wang +22 more
TL;DR: Epigenetic modification of miR-429 can manipulate liver T-ICs by targeting the RBBP4/E2F1/OCT4 axis, thus providing a novel strategy for HCC prevention and treatment.
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CGmapTools improves the precision of heterozygous SNV calls and supports allele-specific methylation detection and visualization in bisulfite-sequencing data
TL;DR: Two methods are designed, BayesWC and BinomWC, that substantially improved the precision of heterozygous SNV calls from ˜80% to 99% while retaining comparable recalls and integrated 40 applications into the software package CGmapTools to analyze DNA methylomes.