Z
Zhenyu Xuan
Researcher at University of Texas at Dallas
Publications - 86
Citations - 13278
Zhenyu Xuan is an academic researcher from University of Texas at Dallas. The author has contributed to research in topics: Gene & Regulation of gene expression. The author has an hindex of 38, co-authored 85 publications receiving 12367 citations. Previous affiliations of Zhenyu Xuan include University of Texas at Austin & Hong Kong University of Science and Technology.
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Journal ArticleDOI
A microRNA component of the p53 tumour suppressor network
Lin He,Xingyue He,Xingyue He,Lee P. Lim,Elisa de Stanchina,Elisa de Stanchina,Zhenyu Xuan,Yu Liang,Wen Xue,Lars Zender,Jill F. Magnus,Dana Ridzon,Aimee L. Jackson,Peter S. Linsley,Caifu Chen,Scott W. Lowe,Michele A. Cleary,Gregory J. Hannon +17 more
TL;DR: A family of miRNAs, miR-34a–c, whose expression reflected p53 status is described, whose encoded genes are direct transcriptional targets of p53, whose induction by DNA damage and oncogenic stress depends on p53 both in vitro and in vivo.
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The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis
TL;DR: Argonaute proteins comprise a highly conserved protein family that is involved in a variety of RNA silencing phenomena in a diverse set of organisms and may ultimately reveal the reach of these pathways into the basic biological mechanisms that underlie a range of human diseases.
Journal ArticleDOI
Genome-wide in situ exon capture for selective resequencing
Emily Hodges,Zhenyu Xuan,Vivekanand Balija,Melissa Kramer,Michael Molla,Steven Smith,Christina M. Middle,Matthew Rodesch,Thomas J. Albert,Gregory J. Hannon,W. Richard McCombie +10 more
TL;DR: This work has developed a method of using flexible, high-density microarrays to capture any desired fraction of the human genome, in this case corresponding to more than 200,000 protein-coding exons, and provides an adaptable route toward rapid and efficient resequencing of any sizeable, non-repeat portion of thehuman genome.
Journal ArticleDOI
Regulating Gene Expression through RNA Nuclear Retention
Kannanganattu V. Prasanth,Supriya G. Prasanth,Zhenyu Xuan,Stephen Hearn,Susan M. Freier,C. Frank Bennett,Michael Q. Zhang,David L. Spector +7 more
TL;DR: A role of the cell nucleus in harboring RNA molecules that are not immediately needed to produce proteins but whose cytoplasmic presence is rapidly required upon physiologic stress is revealed.
Journal ArticleDOI
Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells
Wei Xie,Matthew D. Schultz,Ryan Lister,Zhonggang Hou,Nisha Rajagopal,Pradipta R. Ray,John W. Whitaker,Shulan Tian,R. David Hawkins,Danny Leung,Hongbo Yang,Tao Wang,Ah Young Lee,Scott Swanson,Jiuchun Zhang,Jiuchun Zhang,Yun Zhu,Audrey Kim,Joseph R. Nery,Mark A. Urich,Samantha Kuan,Chia-An Yen,Sarit Klugman,Pengzhi Yu,Kran Suknuntha,Nicholas E. Propson,Huaming Chen,Lee Edsall,Ulrich Wagner,Yan Li,Zhen Ye,Ashwinikumar Kulkarni,Zhenyu Xuan,Wen Yu Chung,Neil C. Chi,Jessica Antosiewicz-Bourget,Igor I. Slukvin,Ron Stewart,Michael Q. Zhang,Michael Q. Zhang,Wei Wang,James A. Thomson,James A. Thomson,James A. Thomson,Joseph R. Ecker,Bing Ren,Bing Ren +46 more
TL;DR: It is found that promoters that are active in early developmental stages tend to be CG rich and mainly engage H3K27me3 upon silencing in nonexpressing lineages, while promoters for genes expressed preferentially at later stages are often CG poor and primarily employ DNA methylation upon repression.