Michael Q. Zhang

TL;DR: A unified coarse-grained competition motif model is built to systematically integrate experimental evidences in these processes and analyzed general properties shared behind them from steady-state behavior to dynamic responses and uncovered the complexity and generality of molecular competition effect as a hidden layer of gene regulatory network.

TL;DR: A novel computational method is developed and validated for testing the existence of hotspots as well as for localizing them with either unphased or phased genotyping data, and found evidence for theexistence of human alpha hotspots similar to those of yeast.

TL;DR: MIROR identified a number of differentially regulated miRNA-mRNA pairs with significant miRNA occupancy rate changes between tumor and normal tissues and indicates that MIROR provides a novel strategy to study the miRNA differential regulation in different cell types.

TL;DR: Results indicate that miR-139, inferred by the gene module based approach, should be a key tumor suppressor in early cancer development.

TL;DR: In this article , the authors show that CTCF functions in a context-specific manner to modulate the 3D genome to enable cellular reprogramming, together with SMARCA5, an imitation switch (ISWI) chromatin remodeler.