M
Michael Q. Zhang
Researcher at Tsinghua University
Publications - 396
Citations - 46412
Michael Q. Zhang is an academic researcher from Tsinghua University. The author has contributed to research in topics: Gene & Chromatin. The author has an hindex of 93, co-authored 378 publications receiving 42008 citations. Previous affiliations of Michael Q. Zhang include Chinese Academy of Sciences & Peking Union Medical College Hospital.
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Journal ArticleDOI
Determination of enriched histone modifications in non-genic portions of the human genome.
Jeffrey A. Rosenfeld,Jeffrey A. Rosenfeld,Jeffrey A. Rosenfeld,Zhibin Wang,Dustin E. Schones,Keji Zhao,Rob DeSalle,Michael Q. Zhang +7 more
TL;DR: This work has extended the analysis of histone modifications to gene deserts, pericentromeres and subtelomeres and found that each of these non-genic regions has a particular profile of hist one modifications that distinguish it from the other non-coding regions.
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In Situ Capture of Chromatin Interactions by Biotinylated dCas9.
Xin Liu,Yuannyu Zhang,Yong Chen,Mushan Li,Feng Zhou,Kailong Li,Hui Cao,Min Ni,Yuxuan Liu,Zhimin Gu,Kathryn E. Dickerson,Shiqi Xie,Gary C. Hon,Zhenyu Xuan,Michael Q. Zhang,Zhen Shao,Jian Xu +16 more
TL;DR: Detailed analysis of chromatin interactions at disease-associated cis-elements and developmentally regulated super-enhancers reveals spatial features that causally control gene transcription that provide mechanistic insight into genome structure and function in development and disease.
Journal ArticleDOI
Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq–based resource for pain and sensory neuroscience research
Pradipta R. Ray,A. Torck,Lilyana Quigley,Andi Wangzhou,Matthew Neiman,Chandranshu Rao,Tiffany Lam,Jiyoung Kim,Tae Hoon Kim,Michael Q. Zhang,Gregory Dussor,Theodore J. Price +11 more
TL;DR: Analysis of human dorsal root ganglia samples from organ donors and RNA-sequencing to study the hDRG transcriptional landscape provides insight into DRG biology for guiding development of novel therapeutics and a blueprint for cross-species transcriptomic analyses.
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High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing
Emily Hodges,Andrew D. Smith,Andrew D. Smith,Jude Kendall,Zhenyu Xuan,Kandasamy Ravi,Michelle Rooks,Michelle Rooks,Michael Q. Zhang,Kenny Ye,Arindam Bhattacharjee,Leonardo Brizuela,W. Richard McCombie,Michael Wigler,Gregory J. Hannon,Gregory J. Hannon,James W. Hicks +16 more
TL;DR: An approach that combines array-based hybrid selection and massively parallel bisulfite sequencing to profile DNA methylation in genomic regions spanning hundreds of thousands of bases is presented, suggesting that chromatin states can foreshadow the content of mature mRNAs.
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Development of the human cancer microRNA network
TL;DR: A cancer-miRNA network is developed by mining the literature of experimentally verified cancer- miRNA relationships and it is found that in 67% of the cancer types have at least two neighboring miRNAs showing downregulation which is statistically significant (P < 10-7, Randomization test).