M
Michael R. Stratton
Researcher at Wellcome Trust Sanger Institute
Publications - 464
Citations - 162105
Michael R. Stratton is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cancer & Mutation. The author has an hindex of 161, co-authored 443 publications receiving 142586 citations. Previous affiliations of Michael R. Stratton include University of Cambridge & The Breast Cancer Research Foundation.
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Journal ArticleDOI
The familial Wilms' tumour susceptibility gene, FWT1 , may not be a tumour suppressor gene
Nazneen Rahman,Laura Arbour,Patricia N. Tonin,Sylvain Baruchel,Kathryn Pritchard-Jones,Steven A. Narod,Michael R. Stratton +6 more
TL;DR: Loss of alleles linked to the disease and the implied absence of the mutated susceptibility gene in one tumour, suggests that a mutation in FWT1 may be necessary for the initiation of some familial Wilms' tumours but subsequently the maintenance of the neoplastic phenotype becomes independent of the F WT1 mutation.
Journal ArticleDOI
Contribution of germline MLH1 and MSH2 mutations to lobular carcinoma in situ of the breast
J G Stone,Glen T. Coleman,Barry A. Gusterson,A Marossy,Sunil R. Lakhani,A Ward,A Nash,A McKinna,Roger A'Hern,Michael R. Stratton,Richard S. Houlston +10 more
TL;DR: Examining a series of 71 LCIS patients for germline MSH2 and MLH1 mutations suggests that mutations in MLH 1 may underlie a subset of LCIS cases.
Journal Article
Detection of transforming genes by transfection of DNA from primary soft-tissue tumours.
S Gill,Michael R. Stratton,Helen Patterson,N K Spurr,Cyril Fisher,Barry A. Gusterson,Colin Cooper +6 more
TL;DR: A series of adult soft-tissue tumours were screened for the presence of activated oncogenes by transfecting tumour DNA into NIH3T3 mouse fibroblasts and an activated K-ras gene that contained a mutation at the second position of codon 12 (GGT----GAT) was found in a leiomyosarcoma.
Posted ContentDOI
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation
Arie B. Brinkman,Serena Nik-Zainal,Femke Simmer,F. Germán Rodríguez-González,Marcel Smid,Ludmil B. Alexandrov,Adam Butler,Sancha Martin,Helen Davies,Dominik Glodzik,Xueqing Zou,Manasa Ramakrishna,Johan Staaf,Markus Ringnér,Anieta M. Sieuwerts,Anthony Ferrari,Sandro Morganella,Thomas Fleischer,Vessela N. Kristensen,Marta Gut,Marc J. van de Vijver,Anne Lise Børresen-Dale,Andrea L. Richardson,Gilles Thomas,Ivo Gut,John W.M. Martens,John A. Foekens,Michael R. Stratton,Hendrik G. Stunnenberg +28 more
TL;DR: Using whole genome bisulfite sequencing of breast cancers, it is comprehensively shown that loss of methylation in PMDs occurs in a large fraction of the genome and represents the prime source of variation in DNA methylation.
Journal ArticleDOI
Using gene carrier probability to select high risk families for identifying germline mutations in breast cancer susceptibility genes.
Jenny Chang-Claude,Juan Dong,Silke Schmidt,M. Shayeghi,D. Komitowski,Heiko Becher,Michael R. Stratton,Brigitte Royer-Pokora +7 more
TL;DR: This investigation investigated whether the prior probability of being a carrier of a dominant breast cancer susceptibility gene in the youngest affected family member could be used to identify families in which the probability of finding a mutation is sufficiently high.