M
Michael R. Stratton
Researcher at Wellcome Trust Sanger Institute
Publications - 464
Citations - 162105
Michael R. Stratton is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cancer & Mutation. The author has an hindex of 161, co-authored 443 publications receiving 142586 citations. Previous affiliations of Michael R. Stratton include University of Cambridge & The Breast Cancer Research Foundation.
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COSMIC: the catalogue of somatic mutations in cancer
Nidhi Bindal,Simon A. Forbes,David Beare,Prasad Gunasekaran,Kenric Leung,Chai Yin Kok,Mingming Jia,Sally Bamford,Charlotte G. Cole,Sari Ward,Jon W. Teague,Michael R. Stratton,Peter J. Campbell,Andrew Futreal +13 more
TL;DR: The Catalogue Of Somatic Mutations In Cancer (COSMIC), one of the largest repositories of information on somatic mutations in human cancer, curates and standardizes this information in a single database, providing user-friendly browsing tools and analytical functions, thus ensuring its role as a key resource inhuman cancer genetics.
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PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene
Nazneen Rahman,Sheila Seal,Deborah J. Thompson,Patrick Kelly,Anthony Renwick,Anna Elliott,Sarah Reid,Katarina Spanova,Rita Barfoot,Tasnim Chagtai,Hiran Jayatilake,Lesley McGuffog,Sandra Hanks,D. Gareth Evans,Diana Eccles,Douglas F. Easton,Michael R. Stratton +16 more
TL;DR: The results show that PALB2 is a breast cancer susceptibility gene and further demonstrate the close relationship of the Fanconi anemia–DNA repair pathway and breast cancer predisposition.
Journal ArticleDOI
Universal Patterns of Selection in Cancer and Somatic Tissues
Inigo Martincorena,Keiran Raine,Moritz Gerstung,Kevin J. Dawson,Kerstin Haase,Peter Van Loo,Peter Van Loo,Helen Davies,Michael R. Stratton,Peter J. Campbell,Peter J. Campbell +10 more
TL;DR: This work adapted methods from molecular evolution and applied them to 7,664 tumors across 29 cancer types, allowing exome-wide enumeration of all driver coding mutations, including outside known cancer genes.
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Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing
Peter J. Campbell,Philip J. Stephens,Erin Pleasance,Sarah O’Meara,Heng Li,Thomas Santarius,Thomas Santarius,Lucy Stebbings,Catherine Leroy,Sarah Edkins,Claire Hardy,Jon W. Teague,Andrew Menzies,Ian Goodhead,Daniel J. Turner,C M Clee,Michael A. Quail,Antony V. Cox,Clive Gavin Brown,Richard Durbin,Matthew E. Hurles,Paul A.W. Edwards,Graham R. Bignell,Michael R. Stratton,P. Andrew Futreal +24 more
TL;DR: The results demonstrate the feasibility of systematic, genome-wide characterization of rearrangements in complex human cancer genomes, raising the prospect of a new harvest of genes associated with cancer using this strategy.
Journal ArticleDOI
The Catalogue of Somatic Mutations in Cancer (COSMIC).
Simon A. Forbes,G. Bhamra,Sally Bamford,Elisabeth Dawson,C. Kok,Jody Clements,Andrew Menzies,Jon W. Teague,P.A. Futreal,Michael R. Stratton +9 more
TL;DR: This unit describes the graphical system in detail, elaborating an example walkthrough and the many ways that the resulting information can be thoroughly investigated by combining data, respecializing the query, or viewing the results in different ways.