M
Michael R. Stratton
Researcher at Wellcome Trust Sanger Institute
Publications - 464
Citations - 162105
Michael R. Stratton is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cancer & Mutation. The author has an hindex of 161, co-authored 443 publications receiving 142586 citations. Previous affiliations of Michael R. Stratton include University of Cambridge & The Breast Cancer Research Foundation.
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Journal ArticleDOI
Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13.
A. M. Cleton-Jansen,N. Collins,Sunil R. Lakhani,Jean Weissenbach,Peter Devilee,Cees J. Cornelisse,Michael R. Stratton +6 more
TL;DR: To investigate the involvement of BRCA2 in sporadic breast cancer 200 breast tumours were tested for LOH, and one cell line showed homozygosity in the BRC a2 region and heterozygosity at RB1, the only indication that BRCa2 is a distinct target for Loh on chromosome 13 in addition to RB1.
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Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14-q22.
Ian Tomlinson,Ian Tomlinson,Ian Tomlinson,Nazneen Rahman,Ian M. Frayling,Jon Mangion,Rita Barfoot,Rifat Hamoudi,Sheila Seal,J. M. A. Northover,Huw Thomas,K Neale,Shirley Hodgson,Ian C. Talbot,Richard S. Houlston,Michael R. Stratton +15 more
TL;DR: It is shown that the Ashkenazi family's phenotype does not result from APC mutations or from genetic changes in the other known genes that predispose to colon cancer, and evidence is provided for a novel colorectal adenoma and carcinoma susceptibility gene, CRAC1, mapping to chromosome 15q14-q22.
Journal Article
Low Frequency of Somatic Mutations in the LKB1/Peutz-Jeghers Syndrome Gene in Sporadic Breast Cancer
TL;DR: The results indicate that mutations in LKB1 do not play an important role in the development of sporadic breast cancer.
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CASK mutations are frequent in males and cause X-linked nystagmus and variable XLMR phenotypes
Anna Hackett,Patrick S. Tarpey,Andrea Licata,James J. Cox,Annabel Whibley,Jackie Boyle,Carolyn J Rogers,John R. Grigg,Michael Partington,Roger E. Stevenson,John Tolmie,John R.W. Yates,Gillian Turner,Meredith Wilson,Andrew Futreal,Mark A. Corbett,Marie Shaw,Jozef Gecz,F. Lucy Raymond,Michael R. Stratton,Charles E. Schwartz,Fatima Abidi +21 more
TL;DR: The phenotypic spectrum is defined and it is demonstrated that affected males with missense mutations or in-frame deletions in CASK are frequently associated with congenital nystagmus and XLMR, a striking feature not previously reported.
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GLO1-A novel amplified gene in human cancer.
Thomas Santarius,Thomas Santarius,Graham R. Bignell,Christopher Greenman,Sara Widaa,Lina Chen,Claire L. Mahoney,Adam Butler,Sarah Edkins,Sahar Waris,Paul J. Thornalley,P. Andrew Futreal,Michael R. Stratton +12 more
TL;DR: Real time quantitative PCR analysis of all amplicon 6p21.2 genes in 618 human cancer cell lines identified GLO1, encoding glyoxalase 1, to be the most frequently amplified gene [twofold or greater amplification in 8.4% (49/536) of cancers].