M
Michael R. Stratton
Researcher at Wellcome Trust Sanger Institute
Publications - 464
Citations - 162105
Michael R. Stratton is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cancer & Mutation. The author has an hindex of 161, co-authored 443 publications receiving 142586 citations. Previous affiliations of Michael R. Stratton include University of Cambridge & The Breast Cancer Research Foundation.
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Journal ArticleDOI
Erratum: A common coding variant in CASP8 is associated with breast cancer risk (Nature Genetics (2007) 39, (352-358))
Angela Cox,Alison M. Dunning,Montserrat Garcia-Closas,Sabapathy P. Balasubramanian,Malcolm W.R. Reed,Karen A. Pooley,Serena Scollen,Caroline Baynes,Bruce A.J. Ponder,Stephen J. Chanock,Jolanta Lissowska,Louise A. Brinton,Beata Peplonska,Melissa C. Southey,John L. Hopper,Margaret R. E. McCredie,Graham G. Giles,Olivia Fletcher,Nichola Johnson,Isabel dos Santos Silva,Lorna Gibson,Stig E. Bojesen,Børge G. Nordestgaard,C K Axelsson,Diana Torres,Ute Hamann,Christina Justenhoven,Hiltrud Brauch,Jenny Chang-Claude,Silke Kropp,Angela Risch,Shan Wang-Gohrke,Peter Schürmann,Natalia Bogdanova,Thilo Dörk,Rainer Fagerholm,Kirsimari Aaltonen,Carl Blomqvist,Heli Nevanlinna,Sheila Seal,Anthony Renwick,Michael R. Stratton,Nazneen Rahman,Suleeporn Sangrajrang,David J. Hughes,Fabrice Odefrey,Paul Brennan,Amanda B. Spurdle,Georgia Chenevix-Trench,Jonathan Beesley,Arto Mannermaa,Jaana M. Hartikainen,Vesa Kataja,Veli Matti Kosma,Fergus J. Couch,Janet E. Olson,Ellen L. Goode,Annegien Broeks,Marjanka K. Schmidt,Frans B. L. Hogervorst,Laura J. van't Veer,Daehee Kang,Keun-Young Yoo,Dong Young Noh,Sei Hyun Ahn,Sara Wedrén,Per Hall,Yen-Ling Low,Jianjun Liu,Roger L. Milne,Gloria Ribas,Anna González-Neira,Javier Benitez,Alice J. Sigurdson,Denise L. Stredrick,Bruce H. Alexander,Jeffery P. Struewing,Paul D.P. Pharoah,Douglas F. Easton +78 more
TL;DR: In the version of this article initially published, there was an error that affected the calculations of the odds ratios, confidence intervals, between-study heterogeneity, trend test and test for association for SNP ICAM5 V301I as discussed by the authors.
Journal ArticleDOI
Exclusion of biglycan mutations in a cohort of patients with neuromuscular disorders.
Rachel A. Peat,Jozef Gecz,Jozef Gecz,Justin R. Fallon,Patrick S. Tarpey,Raffaella Smith,Andrew Futreal,Michael R. Stratton,Shireen R. Lamandé,Nan Yang,Kathryn N. North,Kathryn N. North +11 more
TL;DR: Biglycan has been considered a good candidate for neuromuscular disease based on direct interactions with collagen VI and alpha-dystroglycan, but after family analysis and control screening it was found that none of these polymorphisms were disease-causing mutations.
Posted ContentDOI
Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.
Jonathan S. Brammeld,Mia Petljak,Carla Daniela Robles-Espinoza,Stacey Price,Syd Barthorpe,Patrick S. Tarpey,Constantine Alifrangis,Graham R. Bignell,Mathew J. Garnett,Jamie Young,Lucy Stebbings,Kathryn Beal,Michael R. Stratton,Clara Montagut,Alba Dalmases,Beatriz Bellosillo,Joana Vidal,Julio Saez-Rodriguez,Luz Garcia Alonso,Francesco Iorio,Ultan McDermott +20 more
TL;DR: It is shown that chemically mutagenizing the genome of cancer cells dramatically increases the number of drug-resistant clones and allows the detection of both known and novel drug resistance mutations.
Journal ArticleDOI
Mutagenicity of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in human TP53 knock-in (Hupki) mouse embryo fibroblasts.
Lisa Hölzl-Armstrong,Sarah Moody,Jill E. Kucab,Edwin P. Zwart,Medjda Bellamri,Mirjam Luijten,Robert J. Turesky,Michael R. Stratton,Volker M. Arlt,David H. Phillips +9 more
TL;DR: N-OH-PhIP-induced whole genome mutagenesis in human TP53 knock-in mouse embryo fibroblasts immortalised and subjected to whole genome sequencing (WGS) showed similarity to COSMIC SBS4, 18 and 29 signatures found in human tumours.
Posted ContentDOI
Somatic mutation rates scale with lifespan across mammals
Alex Cagan,Adrian Baez-Ortega,Natalia Brzozowska,Federico Abascal,Tim H. H. Coorens,Mathijs A. Sanders,Mathijs A. Sanders,Andrew R. J. Lawson,Luke M. R. Harvey,Shriram G. Bhosle,David T. Jones,Raul E. Alcantara,Tim Butler,Yvette Hooks,Kirsty Roberts,Elizabeth Anderson,E J Flach,Simon Spiro,Inez Januszczak,Inez Januszczak,Ethan Wrigglesworth,Matthew W. Perkins,Robert Deaville,Megan Druce,Ruzhica Bogeska,Michael D. Milsom,Björn Neumann,Frank Gorman,Fernando Constantino-Casas,Laura E Peachey,Laura E Peachey,Diana Bochynska,Ewan St. John Smith,Moritz Gerstung,Peter J. Campbell,Elizabeth P. Murchison,Michael R. Stratton,Inigo Martincorena +37 more
TL;DR: The authors used whole-genome sequencing of 208 intestinal crypts from 56 individuals to study the landscape of somatic mutation across 16 mammalian species and revealed common mutational processes across mammals.