M
Michael R. Stratton
Researcher at Wellcome Trust Sanger Institute
Publications - 464
Citations - 162105
Michael R. Stratton is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cancer & Mutation. The author has an hindex of 161, co-authored 443 publications receiving 142586 citations. Previous affiliations of Michael R. Stratton include University of Cambridge & The Breast Cancer Research Foundation.
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Journal ArticleDOI
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.
Jiqiu Cheng,Jiqiu Cheng,Jonas Demeulemeester,Jonas Demeulemeester,David C. Wedge,David C. Wedge,Hans Kristian Moen Vollan,Hans Kristian Moen Vollan,Jason J. Pitt,Hege G. Russnes,Bina P. Pandey,Gro Nilsen,Silje Nord,Graham R. Bignell,Kevin P. White,Anne Lise Børresen-Dale,Peter J. Campbell,Vessela N. Kristensen,Michael R. Stratton,Ole Christian Lingjærde,Yves Moreau,Peter Van Loo,Peter Van Loo +22 more
TL;DR: This study builds a compendium of 2218 primary tumours across 12 human cancer types and systematically screen for homozygous deletions and proposes 27 candidate tumour suppressors, including MAFTRR, KIAA1551, and IGF2BP2.
Journal ArticleDOI
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
Young Seok Ju,Jose M. C. Tubio,William Mifsud,Beiyuan Fu,Helen Davies,Manasa Ramakrishna,Yang Li,Lucy R. Yates,Gunes Gundem,Patrick S. Tarpey,Sam Behjati,Elli Papaemmanuil,Sancha Martin,Anthony Fullam,Moritz Gerstung,Jyoti Nangalia,Jyoti Nangalia,Jyoti Nangalia,Anthony R. Green,Anthony R. Green,Carlos Caldas,Carlos Caldas,Åke Borg,Andrew Tutt,Ming Ta Michael Lee,Laura Van't Veer,Laura Van't Veer,Benita Kiat Tee Tan,Samuel Aparicio,Paul N. Span,John W.M. Martens,Stian Knappskog,Stian Knappskog,Anne Vincent-Salomon,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Jorunn E. Eyfjord,Adrienne M. Flanagan,Adrienne M. Flanagan,Christopher S. Foster,David E. Neal,Colin Cooper,Colin Cooper,Rosalind A. Eeles,Sunil R. Lakhani,Sunil R. Lakhani,Christine Desmedt,Gilles Thomas,Andrea L. Richardson,Andrea L. Richardson,Colin A. Purdie,Alastair M Thompson,Ultan McDermott,Fengtang Yang,Serena Nik-Zainal,Peter J. Campbell,Michael R. Stratton +56 more
TL;DR: It is shown that somatically acquired mitochondrial-nuclear genome fusion sequences are present in cancer cells, and the features of the fusion fragments indicate that nonhomologous end joining and/or replication-dependent DNA double-strand break repair are the dominant mechanisms involved.
Journal ArticleDOI
A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers
Dominik Glodzik,Sandro Morganella,Helen Davies,Peter T. Simpson,Yang Li,Xueqing Zou,Javier Diez-Perez,Johan Staaf,Ludmil B. Alexandrov,Ludmil B. Alexandrov,Marcel Smid,Arie B. Brinkman,Inga H. Rye,Inga H. Rye,Hege G. Russnes,Hege G. Russnes,Keiran Raine,Colin A. Purdie,Sunil R. Lakhani,Sunil R. Lakhani,Alastair M. Thompson,Ewan Birney,Hendrik G. Stunnenberg,Marc J. van de Vijver,John W.M. Martens,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Andrea L. Richardson,Gu Kong,Alain Viari,Douglas F. Easton,Gerard I. Evan,Peter J. Campbell,Michael R. Stratton,Serena Nik-Zainal,Serena Nik-Zainal +35 more
TL;DR: A somatic-rearrangement mutational process affecting coding sequences and noncoding regulatory elements and contributing a continuum of driver consequences, from modest to strong effects, thereby supporting a polygenic model of cancer development.
Journal ArticleDOI
Embryonal precursors of Wilms tumor.
Tim H. H. Coorens,Taryn D. Treger,Taryn D. Treger,Taryn D. Treger,Reem Al-Saadi,Reem Al-Saadi,Luiza Moore,Luiza Moore,Maxine G. B. Tran,Thomas J. Mitchell,Thomas J. Mitchell,Thomas J. Mitchell,Suzanne Tugnait,Christine Thevanesan,Matthew D. Young,Thomas R. W. Oliver,Thomas R. W. Oliver,Thomas R. W. Oliver,Minou Oostveen,Minou Oostveen,Grace Collord,Grace Collord,Grace Collord,P. S. Tarpey,Alex Cagan,Yvette Hooks,Mark F. H. Brougham,Ben C Reynolds,Giuseppe Barone,John Anderson,John Anderson,Mette Jorgensen,G. A. Amos Burke,G. A. Amos Burke,Johannes Visser,James Nicholson,James Nicholson,Naima Smeulders,Imran Mushtaq,Grant D. Stewart,Grant D. Stewart,Peter J. Campbell,David C. Wedge,David C. Wedge,Inigo Martincorena,Dyanne Rampling,Liz Hook,Liz Hook,Anne Y. Warren,Anne Y. Warren,Nicholas Coleman,Nicholas Coleman,Tanzina Chowdhury,Neil J. Sebire,Neil J. Sebire,Jarno Drost,Kourosh Saeb-Parsy,Kourosh Saeb-Parsy,Michael R. Stratton,Karin Straathof,Karin Straathof,Kathy Pritchard-Jones,Kathy Pritchard-Jones,Sam Behjati,Sam Behjati,Sam Behjati +65 more
TL;DR: Phylogenetic analyses of bilateral tumors indicated that clonal expansions can evolve before the divergence of left and right kidney primordia, and reveal embryonal precursors from which unilateral and multifocal cancers develop.
Journal ArticleDOI
Whole-Genome Sequencing Reveals Breast Cancers with Mismatch Repair Deficiency.
Helen Davies,Sandro Morganella,Colin A. Purdie,Se Jin Jang,Elin Borgen,Hege G. Russnes,Dominik Glodzik,Xueqing Zou,Alain Viari,Andrea L. Richardson,Anne Lise Børresen-Dale,Alastair M. Thompson,Jorunn E. Eyfjord,Gu Kong,Michael R. Stratton,Serena Nik-Zainal,Serena Nik-Zainal +16 more
TL;DR: Patterns of mutagenesis known as mutational signatures, which are imprints of the mutagenic processes associated with MMR deficiency, are utilized to identify MMR-deficient breast tumors from a whole-genome sequencing dataset comprising a cohort of 640 patients.