M
Michael R. Stratton
Researcher at Wellcome Trust Sanger Institute
Publications - 464
Citations - 162105
Michael R. Stratton is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cancer & Mutation. The author has an hindex of 161, co-authored 443 publications receiving 142586 citations. Previous affiliations of Michael R. Stratton include University of Cambridge & The Breast Cancer Research Foundation.
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Life without mismatch repair
Mathijs A. Sanders,Mathijs A. Sanders,Harald Vöhringer,Victoria J. Forster,Luiza Moore,Brittany Campbell,Yvette Hooks,Melissa Edwards,Vanessa Bianchi,Tim H. H. Coorens,Tim Butler,Henry Lee-Six,Philip S. Robinson,Philip S. Robinson,Christoffer Flensburg,Christoffer Flensburg,Rebecca A. Bilardi,Rebecca A. Bilardi,Ian J. Majewski,Ian J. Majewski,Agnes Reschke,Elizabeth Cairney,Bruce Crooks,Scott Lindhorst,Duncan Stearns,Patrick Tomboc,Ultan McDermott,Ultan McDermott,Michael R. Stratton,Adam Shlien,Moritz Gerstung,Uri Tabori,Peter J. Campbell +32 more
TL;DR: In this article, the authors performed whole-genome sequencing of normal and neoplastic tissues from individuals with constitutional MMR deficiency to establish the roles of MMR components, tissue type and disease state in somatic mutation rates.
Journal ArticleDOI
Localisation of the breast-ovarian cancer susceptibility gene (BRCA1) on 17q12-21 to an interval of < or = 1 cM.
Simon A. Smith,R A DiCioccio,J. P. Struewing,Doug Easton,Gallion Hh,Albertsen H,Sylvie Mazoyer,Johansson B,E Steichen-Gersdorf,Michael R. Stratton +9 more
TL;DR: Analysis of three marker‐disease recombinants in families that contain breast and ovarian cancer strongly suggest a location for BRCAI telomeric to D17S702, a microsatellite polymorphism, and a third which suggests a location centromeric to EDH17B, the gene encoding estradiol‐17B dehydrogenase.
Journal ArticleDOI
AutoCSA, an algorithm for high throughput DNA sequence variant detection in cancer genomes
Ed Dicks,Jon W. Teague,Phil Stephens,Keiran Raine,Andrew D. Yates,C. Mattocks,Patrick S. Tarpey,Adam Butler,Andy Menzies,David S. Richardson,Andy Jenkinson,Helen Davies,Sarah Edkins,Simon A. Forbes,Kristian Gray,Christopher Greenman,Rebecca Shepherd,Michael R. Stratton,P A Futreal,Richard Wooster +19 more
TL;DR: This work has developed a mutation detection algorithm, AutoCSA, specifically optimized for the high throughput screening of cancer samples, specifically designed for the large-scale DNA sequencing screens for somatic variants in human cancers.
Journal ArticleDOI
Corrigendum: Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.
Young Seok Ju,Jose M. C. Tubio,William Mifsud,Beiyuan Fu,Helen Davies,Manasa Ramakrishna,Yang Li,Lucy R. Yates,Gunes Gundem,Patrick S. Tarpey,Sam Behjati,Elli Papaemmanuil,Sancha Martin,Anthony Fullam,Moritz Gerstung,Jyoti Nangalia,Anthony R. Green,Carlos Caldas,Åke Borg,Andrew Tutt,Ming Ta Michael Mt Lee,Laura Van't Veer,Benita Kiat Tee Bk Tan,Samuel Aparicio,Paul N. Span,John W.M. Martens,Stian Knappskog,Anne Vincent-Salomon,Anne Lise Børresen-Dale,Jorunn E. Eyfjord,Ola Myklebost,Adrienne M. Flanagan,Christopher S. Foster,David E. Neal,Colin Cooper,Rosalind A. Eeles,Steven Gs Bova,Sunil R. Lakhani,Christine Desmedt,Gilles Thomas,Andrea L. Richardson,Colin A. Purdie,Alastair M Thompson,Ultan McDermott,Fengtang Yang,Serena Nik-Zainal,Peter J. Campbell,Michael R. Stratton +47 more
TL;DR: The names of two co-authors, Ola Myklebost and G. Steven Bova, were omitted from the authorship list of this article and the author and affiliation lists have already been corrected.
Journal ArticleDOI
In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation
Ogechi Ikediobi,Mark Reimers,Steffen Durinck,Paul E. Blower,Andrew Futreal,Michael R. Stratton,John N. Weinstein +6 more
TL;DR: The studies provide evidence that BRAF mutation (codon 600) in melanoma as opposed to RAS mutation is predictive of an increase in sensitivity to phenothiazines as determined by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-sulfophenyl-2H-tetrazolium, inner salt assay (Wilcoxon P = 0.007).