M
Michael R. Stratton
Researcher at Wellcome Trust Sanger Institute
Publications - 464
Citations - 162105
Michael R. Stratton is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cancer & Mutation. The author has an hindex of 161, co-authored 443 publications receiving 142586 citations. Previous affiliations of Michael R. Stratton include University of Cambridge & The Breast Cancer Research Foundation.
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Journal ArticleDOI
Genome Sequencing and Analysis of the Tasmanian Devil and Its Transmissible Cancer
Elizabeth P. Murchison,Ole Schulz-Trieglaff,Zemin Ning,Ludmil B. Alexandrov,Markus J. Bauer,Beiyuan Fu,Matthew M. Hims,Zhihao Ding,Sergii Ivakhno,Caitlin Stewart,Bee Ling Ng,Wendy S.W. Wong,Bronwen Aken,Simon D. M. White,Amber E. Alsop,Jennifer Becq,Graham R. Bignell,R. Keira Cheetham,William Cheng,Thomas R. Connor,Anthony J. Cox,Zhi-Ping Feng,Zhi-Ping Feng,Yong Gu,Russell J. Grocock,Simon R. Harris,Irina Khrebtukova,Zoya Kingsbury,Mark Kowarsky,Alexandre Kreiss,Shujun Luo,John Marshall,David J. McBride,Lisa Murray,Anne-Maree Pearse,Keiran Raine,Isabelle Rasolonjatovo,Richard Shaw,Philip Tedder,Carolyn Tregidgo,Albert J. Vilella,David C. Wedge,Gregory M. Woods,Niall Anthony Gormley,Sean Humphray,Gary P. Schroth,Geoffrey Paul Smith,Kevin Hall,Stephen M. J. Searle,Nigel P. Carter,Anthony T. Papenfuss,Anthony T. Papenfuss,P. Andrew Futreal,Peter J. Campbell,Fengtang Yang,David R. Bentley,Dirk J. Evers,Michael R. Stratton +57 more
TL;DR: Genomic analysis suggests that the cancer first arose from a female Tasmanian devil and that the clone has subsequently genetically diverged during its spread across Tasmania.
Journal ArticleDOI
DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome
Ingrid Slade,Chiara Bacchelli,Helen Davies,Anne Murray,Fatemeh Abbaszadeh,Sandra Hanks,Rita Barfoot,Amos Burke,Julia C. Chisholm,Martin Hewitt,Helen Jenkinson,Derek J. King,Bruce Morland,Barry Pizer,Katrina Prescott,Anand Saggar,Lucy Side,Heidi Traunecker,Sucheta Vaidya,Paul Ward,P. Andrew Futreal,Gordan M. Vujanic,Andrew G. Nicholson,Neil J. Sebire,Clare Turnbull,John R. Priest,Kathryn Pritchard-Jones,Richard S. Houlston,Charles A. Stiller,Michael R. Stratton,Jenny Douglas,Nazneen Rahman +31 more
TL;DR: Constitutional DICER1 haploinsufficiency predisposes to a broad range of tumours, making a substantial contribution to PPB, cystic nephroma and ovarian Sertoli–Leydig tumour, but a smaller contribution to other tumours.
Journal ArticleDOI
Whole genome DNA copy number changes identified by high density oligonucleotide arrays.
Jing Huang,Wen Wei,Jane Zhang,Guoying Liu,Graham R. Bignell,Michael R. Stratton,P. Andrew Futreal,Richard Wooster,Keith W. Jones,Michael H. Shapero +9 more
TL;DR: A novel algorithm that uses a recently developed high-density oligonucleotide array-based SNP genotyping method, whole genome sampling analysis (WGSA), to identify genome-wide chromosomal gains and losses at high resolution and can tolerate samples which contain a mixture of both tumour and normal DNA.
Journal ArticleDOI
Genomics and the continuum of cancer care.
TL;DR: Progress in the genomic analysis of cancer is reviewed, involving assay of the expression of thousands of genes, and systematic DNA sequencing.
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A survey of RNA editing in human brain.
TL;DR: A survey of RNA editing in human brain by comparing sequences of clones from a human brain cDNA library to the reference human genome sequence and to genomic DNA from the same individual strongly supports the idea that formation of intramolecular double-stranded RNA with an inverted copy underlies most A-->I editing.