M
Michael R. Stratton
Researcher at Wellcome Trust Sanger Institute
Publications - 464
Citations - 162105
Michael R. Stratton is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cancer & Mutation. The author has an hindex of 161, co-authored 443 publications receiving 142586 citations. Previous affiliations of Michael R. Stratton include University of Cambridge & The Breast Cancer Research Foundation.
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Journal ArticleDOI
Terminology for carcinoma-in-situ of the breast
Cecily Quinn,Julian L. Ostrowski,Dwight K. Oxley,J. P. Sloane,Sunil R. Lakhani,Michael R. Stratton,Michael J. Baum,Jean F. Simpson,Roy A. Jensen,David L. Page +9 more
Journal ArticleDOI
604 Cancer Genomics, Epigenetics and Genomic Instability. Mutational Processes Shaping the Genomes of Twenty-one Breast Cancers
Serena Nik-Zainal,L. Alexandrov,David C. Wedge,P Van Loo,Keiran Raine,David R. Jones,P.A. Futreal,Peter J. Campbell,Michael R. Stratton +8 more
Posted ContentDOI
The mutational profile and clonal landscape of the inflammatory bowel disease affected colon
Sigurgeir Olafsson,Rebecca E. McIntyre,Tim H. H. Coorens,Tim Butler,Philip Robinson,Henry Lee-Six,Mathijs A. Sanders,Mathijs A. Sanders,Kenneth Arestang,Claire Dawson,Monika Tripathi,Konstantina Strongili,Yvette Hooks,Michael R. Stratton,Miles Parkes,Inigo Martincorena,Tim Raine,Peter J. Campbell,Carl A. Anderson +18 more
TL;DR: The base substitution rate of affected colonic epithelial cells to be doubled after IBD onset and non-synonymous mutations in ARID1A, PIGR and ZC3H12A, and genes in the interleukin 17 and Toll-like receptor pathways, were under positive selection in colonic crypts from IBD patients.
Posted ContentDOI
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
Philip S. Robinson,Philip S. Robinson,Laura E. Thomas,Federico Abascal,Hyunchul Jung,Luke M. R. Harvey,Hannah West,Sigurgeir Olafsson,Bernard C H Lee,Bernard C H Lee,Tim H. H. Coorens,Henry Lee-Six,Laura Butlin,Nicola Lander,Mathijs A. Sanders,Mathijs A. Sanders,Stefanie V Lensing,Simon J.A. Buczacki,Rogier ten Hoopen,Nicholas Coleman,Nicholas Coleman,Roxanne Brunton-Sim,Simon M. Rushbrook,Simon M. Rushbrook,Kourosh Saeb-Parsy,Fiona Lalloo,Peter J. Campbell,Inigo Martincorena,Julian R. Sampson,Michael R. Stratton +29 more
TL;DR: In this paper, the authors sequenced normal tissue DNAs from 10 individuals with MAP and found that the mutation rates in normal cells were increased 2 to 5-fold in all individuals, except for one showing a 33-fold increase, and also increased in other tissues.
Extended Data Figure 8
Yang Li,Claire Schwab,Sarra Ryan,Elli Papaemmanuil,Hazel M. Robinson,Patricia Jacobs,Anthony V. Moorman,Sara Dyer,Julian Borrow,Mike Griffiths,Nyla A. Heerema,Andrew J. Carroll,Polly Talley,Nick Bown,Nick Telford,Fiona M. Ross,Lorraine Gaunt,Richard J. Q. McNally,Bryan D. Young,Paul Sinclair,Vikki Rand,Manuel R. Teixeira,Olivia Joseph,Ben Robinson,Mark Maddison,Nicole Dastugue,Peter Vandenberghe,Philip J. Stephens,Jiqiu Cheng,Peter Van Loo,Michael R. Stratton,Peter J. Campbell,Christine J. Harrison +32 more