M
Michael R. Stratton
Researcher at Wellcome Trust Sanger Institute
Publications - 464
Citations - 162105
Michael R. Stratton is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cancer & Mutation. The author has an hindex of 161, co-authored 443 publications receiving 142586 citations. Previous affiliations of Michael R. Stratton include University of Cambridge & The Breast Cancer Research Foundation.
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Journal ArticleDOI
Journeys into the genome of cancer cells.
TL;DR: A clinical vocation in histopathology, a discipline that couples exposure to the sights and smells of the autopsy room with a daily journey into the often beautiful, sometimes ugly world of healthy and diseased human tissues under the microscope.
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Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors
Bram Herpers,Berina Eppink,Mark I. James,Carme Cortina,Adrià Cañellas-Socias,Sylvia F. Boj,Xavier Hernando-Momblona,Dominik Glodzik,R C Roovers,Marc van de Wetering,Carina Bartelink-Clements,Vanessa Zondag-van der Zande,Jara García Mateos,Kuan Yan,Lucia Salinaro,Abdul Hafid Basmeleh,Szabolcs Fatrai,David Maussang,Jeroen J. Lammerts van Bueren,Irene Chicote,Garazi Serna,Laia Cabellos,Lorena Ramírez,Paolo Nuciforo,Ramon Salazar,Cristina Santos,Alberto Villanueva,Camille Stephan-Otto Attolini,Elena Sancho,Hector G. Palmer,Josep Tabernero,Michael R. Stratton,John de Kruif,Ton Logtenberg,Hans Clevers,Leo S. Price,Robert G.J. Vries,Eduard Batlle,Mark Throsby +38 more
TL;DR: In this article , a large-scale functional screen of dual-targeting bispecific antibodies (bAbs) on a heterogeneous colorectal cancer PDO biobank and paired healthy colonic mucosa samples was described.
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Somatic structural rearrangements in genetically engineered mouse mammary tumors
Ignacio Varela,Christiaan Klijn,Christiaan Klijn,Phillip J. Stephens,Laura Mudie,Lucy Stebbings,Danushka Galappaththige,Hanneke van der Gulden,Eva Schut,Sjoerd Klarenbeek,Peter J. Campbell,Lodewyk F. A. Wessels,Lodewyk F. A. Wessels,Michael R. Stratton,Jos Jonkers,P. Andrew Futreal,David J. Adams +16 more
TL;DR: Paired-end sequencing of mouse mammary tumors revealed that they display significant heterogeneity in their profiles of somatic rearrangement but, importantly, fewer rearrangements than cognate human mammary cancers, probably because these cancers have been induced by strong driver mutations engineered into the mouse genome.
Journal Article
An Interstitial Tandem Duplication of 9p23–24 Coexists with a Mutation in the BRCA2 Gene in the Germ Line of Three Brothers with Breast Cancer
Larissa Savelyeva,Andreas Claas,Simone Gier,Peter M. Schlag,L. H. Finke,Jonathan Mangion,Michael R. Stratton,Manfred Schwab +7 more
TL;DR: A family in which three brothers with breast cancer carry in their germ line two genetic abnormalities: an insertion A at nucleotide 2041 in exon 10 of BRCA2, which leads to premature termination of the encoded protein at codon 615, and a tandem interstitial duplication involving chromosome bands 9p23-24 is reported.
Journal ArticleDOI
BRCA1 and BRCA2 germline mutations in Sardinian breast cancer families and their implications for genetic counseling
Giuseppe Palmieri,Grazia Palomba,Antonio Cossu,Marina Pisano,M.F. Dedola,Maria Giuseppa Sarobba,Antonio Farris,N. Olmeo,Antonio Contu,A Pasca,Mp Satta,Ivana Persico,Annangela Carboni,Paolo Cossu-Rocca,M. Contini,J. Mangion,Michael R. Stratton,Francesco Tanda +17 more
TL;DR: The first report of a detailed BRCA1/2 mutation screening in Sardinia, having immediate implications for the clinical management of BC families is presented in this article. But, the results of this study are limited.