M
Michel Bouvier
Researcher at Université de Montréal
Publications - 412
Citations - 33931
Michel Bouvier is an academic researcher from Université de Montréal. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 97, co-authored 396 publications receiving 31267 citations. Previous affiliations of Michel Bouvier include École Polytechnique de Montréal & University of Catania.
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Journal ArticleDOI
A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation
Terence E. Hébert,Serge Moffett,Jean-Pierre Morello,Thomas P. Loisel,Daniel G. Bichet,Cécile Barret,Michel Bouvier +6 more
TL;DR: It is demonstrated that β2-adrenergic receptors do form SDS-resistant homodimers and that transmembrane domain VI of the receptor may represent part of an interface for receptor dimerization, which suggests that interconversion between monomeric and dimeric forms may be important for biological activity.
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Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET).
Stephane Angers,Ali Salahpour,Eric Joly,Sandrine Hilairet,Dan Chelsky,Michael Dennis,Michel Bouvier +6 more
TL;DR: The data demonstrate that GPCR exist as functional dimers in vivo and that BRET-based assays can be used to study both constitutive and hormone-promoted selective protein–protein interactions.
Journal ArticleDOI
Roles of G-protein-coupled receptor dimerization.
Sonia Terrillon,Michel Bouvier +1 more
TL;DR: The concept of dimerization could be important in the development and screening of drugs that act through this receptor class, and the changes in ligand‐binding and signalling properties that accompany heterodimerization could give rise to an unexpected pharmacological diversity that would need to be considered.
Journal ArticleDOI
Oligomerization of G-protein-coupled transmitter receptors
TL;DR: The evidence supporting the existence of G-protein-coupled-receptor dimerization is reviewed and its functional importance is discussed to have important implications for the development and screening of new drugs.
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Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function.
TL;DR: The reports of heterodimerization between receptor subtypes suggest a potential level of receptor complexity that could account for previously unexpected pharmacological diversities and change views on the structure and activation processes of GPCRs.