M
Michel de Chaldée
Researcher at Centre national de la recherche scientifique
Publications - 6
Citations - 306
Michel de Chaldée is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Huntingtin & Neurodegeneration. The author has an hindex of 6, co-authored 6 publications receiving 282 citations. Previous affiliations of Michel de Chaldée include Université Paris-Saclay & University of Paris-Sud.
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Journal ArticleDOI
Additional support for schizophrenia linkage on chromosomes 6 and 8: A multicenter study
Dieter B. Wildenauer,Sibylle G. Schwab,Margot Albus,Joachim Hallmayer,Bernard Lerer,Wolfgang Maier,Douglas Blackwood,Walter J. Muir,David St Clair,S. W. Morris,Hans W. Moises,Liu Yang,H. Kristbjarnarson,Tómas Helgason,Claudia Wiese,David A. Collier,Peter Holmans,Jo Daniels,Mark I. Rees,Philip Asherson,Queta Roberts,Alastair G. Cardno,Maria Arranz,Homero Vallada,David Ball,Hiroshi Kunugi,Robin M. Murray,John Powell,Sin Nanko,Pak C. Sham,Michael Gill,Peter McGuffin,Michael J. Owen,Ann E. Pulver,Stylianos E. Antonarakis,Robert Babb,Jean-Louis Blouin,Nicola DeMarchi,Beth A. Dombroski,David E. Housman,Maria Karayiorgou,Jurg Ott,Laura Kasch,Haig H. Kazazian,Virginia K. Lasseter,Erika Loetscher,Hermann Luebbert,Gerald Nestadt,Carl Ton,Paula S. Wolyniec,Claudine Laurent,Michel de Chaldée,Florence Thibaut,M. Jay,Danièle Samolyk,Michel Petit,Dominique Campion,Jacques Mallet,Richard E. Straub,C J MacLean,Stephen M. Easter,F. Anthony O'Neill,Dermot Walsh,Kenneth S. Kendler,Pablo V. Gejman,Qiuhe Cao,Elliot S. Gershon,Judith A. Badner,Ethiopia Beshah,Jing Zhang,Brien P. Riley,Swarnageetha Rajagopalan,Mpala Mogudi-Carter,Trefor Jenkins,Robert Williamson,Lynn E. DeLisi,Chad Garner,Mary Kelly,Carrie LeDuc,Lon R. Cardon,Jay B. Lichter,Tim Harris,J. Loftus,Gail Shields,Margarite Comasi,Antonio Vita,Angela B. Smith,Jay Dann,Geoff Joslyn,Hugh Gurling,Gursharan Kalsi,J Brynjolfsson,David Curtis,Thordur Sigmundsson,R Butler,T Read,P Murphy,Andrew Chih-Hui Chen,Hannes Petursson,Bill Byerley,Mark Hoff,John Holik,Hilary Coon,Douglas F. Levinson,Derek J. Nancarrow,Derek J. Nancarrow,Raymond R. Crowe,Nancy C. Andreasen,Jeremy M. Silverman,Richard C. Mohs,Larry J. Siever,Jean Endicott,Lawrence Sharpe,Marilyn K. Walters,David P. Lennon,Nicholas K. Hayward,Lodewijk A. Sandkuijl,Bryan J. Mowry,Harald N. Aschauer,K. Meszaros,Elisabeth Lenzinger,Karoline Fuchs,Angela M. Heiden,Leonid Kruglyak,Mark J. Daly,Tara C. Matise +125 more
TL;DR: Results are interpreted as inconclusive but suggestive of linkage in the latter two regions, and it is concluded that multicenter follow-up linkage studies of complex disorders can help to direct research efforts toward promising regions.
Journal ArticleDOI
The striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo
Laetitia Francelle,Laurie Galvan,Marie-Claude Gaillard,Fanny Petit,Benoit Bernay,Benoit Bernay,Martine Guillermier,Gilles Bonvento,Noelle Dufour,Jean-Marc Elalouf,Jean-Marc Elalouf,Philippe Hantraye,Nicole Déglon,Michel de Chaldée,Michel de Chaldée,Emmanuel Brouillet +15 more
TL;DR: It is confirmed that despite the presence of 2 small open reading frames (ORFs) in its sequence, Abhd11os is not translated into a detectable peptide in living cells, which indicates that the loss lncRNA Abhd 11os likely contribute to striatal vulnerability in HD.
Journal ArticleDOI
No evidence for linkage between COMT and schizophrenia in a French population.
Michel de Chaldée,Marilys Corbex,Dominique Campion,M. Jay,Danièle Samolyk,Michel Petit,Florence Thibaut,Claudine Laurent,Jacques Mallet +8 more
TL;DR: A multipoint non-parametric linkage analysis and a transmission disequilibrium test were performed on 42 multiplex families genotyped for Pml I and Bcl I polymorphisms, and neither linkage nor preferential transmission of any allele or haplotype was detected.
Journal ArticleDOI
Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease
Laetitia Francelle,Laurie Galvan,Marie-Claude Gaillard,Martine Guillermier,Diane Houitte,Gilles Bonvento,Fanny Petit,Caroline Jan,Noelle Dufour,Philippe Hantraye,Jean-Marc Elalouf,Jean-Marc Elalouf,Michel de Chaldée,Michel de Chaldée,Nicole Déglon,Nicole Déglon,Emmanuel Brouillet +16 more
TL;DR: It is shown that overexpression of Crym in striatal medium-size spiny neurons using a lentiviral-based strategy in mice is neuroprotective against the neurotoxicity of an N-terminal fragment of mHtt in vivo, suggesting that Crym may be a key determinant of the vulnerability of the striatum.
Journal ArticleDOI
The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.
Laurie Galvan,Laetitia Francelle,Marie-Claude Gaillard,Lucie de Longprez,Maria-Angeles Carrillo-de Sauvage,Géraldine Liot,Karine Cambon,Lev Stimmer,Sophie Luccantoni,Julien Flament,Julien Valette,Michel de Chaldée,Gwenaëlle Auregan,Martine Guillermier,Charlène Joséphine,Fanny Petit,Caroline Jan,Margot Jarrige,Noelle Dufour,Gilles Bonvento,Sandrine Humbert,Sandrine Humbert,Frédéric Saudou,Frédéric Saudou,Philippe Hantraye,Karine Merienne,Alexis-Pierre Bemelmans,Anselme L. Perrier,Nicole Déglon,Emmanuel Brouillet +29 more
TL;DR: It is reported that DCLK3 silencing in the mouse striatum exacerbates the toxicity of mutant huntingtin, whereas D CLK3 overexpression is neuroprotective, and it is shown that DclK3 regulates the expression of many genes involved in transcription regulation and chromatin remodelling.