M
Michela Gallagher
Researcher at Johns Hopkins University
Publications - 297
Citations - 33385
Michela Gallagher is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Hippocampal formation & Hippocampus. The author has an hindex of 95, co-authored 293 publications receiving 31710 citations. Previous affiliations of Michela Gallagher include University of Vermont & Texas A&M University.
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Journal ArticleDOI
A specific amyloid-|[beta]| protein assembly in the brain impairs memory
Sylvain Lesné,Ming Teng Koh,Linda Kotilinek,Rakez Kayed,Charles G. Glabe,Austin J. Yang,Michela Gallagher,Karen H. Ashe +7 more
TL;DR: It is found that memory deficits in middle-aged Tg2576 mice are caused by the extracellular accumulation of a 56-kDa soluble amyloid-β assembly, which is proposed to be Aβ*56 (Aβ star 56), which may contribute to cognitive deficits associated with Alzheimer's disease.
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Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning
TL;DR: In this article, the authors examined neural activity in rat orbitofrontal cortex and basolateral amygdala during instrumental learning in an olfactory discrimination task and found that neurons in both regions fired selectively during the anticipation of rewarding or aversive outcomes.
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Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze.
TL;DR: New measures that provide information about the spatial distribution of the rat's search during both training and probe trial performance are described and a learning index that provides a continuous, graded measure of the severity of age-related impairment in the Morris water maze task is described.
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Phosphorylation of the AMPA Receptor GluR1 Subunit Is Required for Synaptic Plasticity and Retention of Spatial Memory
Hey Kyoung Lee,Kogo Takamiya,Jung-Soo Han,Heng-Ye Man,Chong Hyun Kim,Gavin Rumbaugh,Sandy Yu,Lin Ding,Chun He,Ronald S. Petralia,Robert J. Wenthold,Michela Gallagher,Richard L. Huganir +12 more
TL;DR: It is demonstrated that phosphorylation of GluR1 is critical for LTD and LTP expression and the retention of memories.
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Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment.
Arnold Bakker,Gregory L. Krauss,Marilyn S. Albert,Caroline L. Speck,Lauren R. Jones,Craig E.L. Stark,Michael A. Yassa,Susan Spear Bassett,Amy L. Shelton,Michela Gallagher +9 more
TL;DR: The view that increased hippocampal activation in aMCI is a dysfunctional condition and that targeting excess hippocampal activity has therapeutic potential is supported.