M
Mirja Tamara Prentzell
Researcher at German Cancer Research Center
Publications - 5
Citations - 391
Mirja Tamara Prentzell is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Stress granule & Cell. The author has an hindex of 4, co-authored 5 publications receiving 232 citations.
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Journal ArticleDOI
IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression
Ahmed Sadik,Luis F. Somarribas Patterson,Selcen Öztürk,Soumya R. Mohapatra,Verena Panitz,Philipp F Secker,Pauline Pfänder,Stefanie Loth,Heba Salem,Mirja Tamara Prentzell,Bianca Berdel,Murat Iskar,Erik Faessler,Friederike Reuter,Isabelle Kirst,Verena Kalter,Kathrin I. Foerster,Evelyn Jäger,Carina Ramallo Guevara,Mansour Sobeh,Thomas Hielscher,Gernot Poschet,Annekathrin Reinhardt,Jessica C. Hassel,Marc Zapatka,Udo Hahn,Andreas von Deimling,Carsten Hopf,Rita Schlichting,Beate I. Escher,Jürgen Burhenne,Walter E. Haefeli,Naveed Ishaque,Alexander Böhme,Sascha Schäuble,Kathrin Thedieck,Saskia Trump,Martina Seiffert,Christiane A. Opitz +38 more
TL;DR: A pan-tissue AHR signature revealed that across 32 tumor entities, interleukin-4-induced-1 (IL4I1) associates more frequently with AHR activity than IDO1 or TDO2, hitherto recognized as the main Trp-catabolic enzymes.
Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells : erratum (Cell 154, 859–874; August 15, 2013)
Kathrin Thedieck,Birgit Holzwarth,Mirja Tamara Prentzell,Christopher Boehlke,Kathrin Kläsener,Stefanie Ruf,Annika G Sonntag,Lars Maerz,Sushma Nagaraja Grellscheid,Elisabeth Kremmer,Roland Nitschke,E. Wolfgang Kuehn,Johan W. Jonker,Albert K. Groen,Michael Reth,Michael N. Hall,Ralf Baumeister +16 more
TL;DR: It is shown that in cancer cells, apoptosis suppression during stress depends on astrin, and this work establishes a unifying model of mTORC1 inhibition and activation upon stress.
Journal ArticleDOI
Resistance Exercise Reduces Kynurenine Pathway Metabolites in Breast Cancer Patients Undergoing Radiotherapy.
Philipp Zimmer,Martina E. Schmidt,Mirja Tamara Prentzell,Bianca Berdel,Joachim Wiskemann,Karl Heinz Kellner,Jürgen Debus,Cornelia M. Ulrich,Christiane A. Opitz,Christiane A. Opitz,Karen Steindorf +10 more
TL;DR: Resistance exercise may represent a potent non-pharmacological avenue to counteract an activation of the KYN pathway in breast cancer patients undergoing radiotherapy.
Journal ArticleDOI
Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBPβ.
Takumi Kudo,Takumi Kudo,Takumi Kudo,Mirja Tamara Prentzell,Soumya R. Mohapatra,Felix Sahm,Felix Sahm,Zhongliang Zhao,Ingrid Grummt,Wolfgang Wick,Christiane A. Opitz,Michael Platten,Michael Platten,Edward W. Green,Edward W. Green +14 more
TL;DR: Evidence is provided for a novel regulatory and therapeutically targetable pathway of immunosuppressive tryptophan degradation in a subtype of glioblastoma with a particularly poor prognosis.
Posted ContentDOI
G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules
Mirja Tamara Prentzell,Ulrike Rehbein,Ulrike Rehbein,Marti Cadena Sandoval,Marti Cadena Sandoval,De Wildeman Stefaan M A,Ralf Baumeister,Laura Brohée,Bianca Berdel,Mathias Bockwoldt,Bernadette Carroll,von Deimling A,Constantinos Demetriades,Constantinos Demetriades,Gianluca Figlia,Gianluca Figlia,Alexander Martin Heberle,Alexander Martin Heberle,Ines Heiland,Birgit Holzwarth,Lukas A. Huber,Jacek Jaworski,Katharina Kern,Kopach A,Viktor I. Korolchuk,van ’t Land-Kuper I,van ’t Land-Kuper I,Matylda Macias,Mark Nellist,Stefan Pusch,Reil M,Anja Reintjes,Friederike Reuter,Chloë Scheldeman,Eduard Stefan,Aurelio A. Teleman,Aurelio A. Teleman,Omar Torres-Quesada,Saskia Trump,de Witte P,Teodor E. Yordanov,Teodor E. Yordanov,Christiane A. Opitz,Christiane A. Opitz,Kathrin Thedieck,Kathrin Thedieck,Kathrin Thedieck +46 more
TL;DR: It is reported that in the absence of SG, G3BP1 acts as lysosomal anchor of the Tuberous Sclerosis Complex (TSC) protein complex, tethers the TSC complex to lysoomes, and suppresses signaling through the metabolic master regulator mTORC1.