N
N. Collins
Researcher at Institute of Cancer Research
Publications - 26
Citations - 10028
N. Collins is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Breast cancer & Loss of heterozygosity. The author has an hindex of 23, co-authored 26 publications receiving 9697 citations. Previous affiliations of N. Collins include The Royal Marsden NHS Foundation Trust.
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Journal ArticleDOI
Identification of the breast cancer susceptibility gene BRCA2
Richard Wooster,Graham R. Bignell,Johnathan M. Lancaster,Sally Swift,Sheila Seal,Jonathon Mangion,N. Collins,Simon G. Gregory,Curtis Gumbs,Gos Micklem +9 more
TL;DR: The identification of a gene in which six different germline mutations in breast cancer families that are likely to be due to BRCA2 are detected, and results indicate that this is the BRC a2 gene.
Journal ArticleDOI
Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
Richard Wooster,Susan L. Neuhausen,Jonathan Mangion,Yvette Quirk,D Ford,N. Collins,K. Nguyen,Sheila Seal,T.D. Tran,D. Averill,P Fields,Gill Marshall,Steven A. Narod,Gilbert M. Lenoir,Henry T. Lynch,Jean Feunteun,Peter Devilee,Cees J. Cornelisse,Fred H. Menko,Peter A. Daly,Wilma Ormiston,Ross McManus,Carole Pye,Cathryn M. Lewis,Lisa A. Cannon-Albright,Julian Peto,Bruce A.J. Ponder,Mark H. Skolnick,Douglas F. Easton,David E. Goldgar,Michael R. Stratton +30 more
TL;DR: This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13, which preliminary evidence suggests suggests confers a high risk of breast cancer but does not confer a substantially elevated risk of ovarian cancer.
Journal ArticleDOI
Erratum: Identification of the breast cancer susceptibility gene BRCA2
Richard Wooster,Graham R. Bignell,Jonathan Lancaster,Sally Swift,Sheila Seal,Jonathan Mangion,N. Collins,Simon G. Gregory,Curtis Gumbs,Gos Michlem,Rita Barfoot,Rifat Hamoudi,Sandeep Patel,Catherine M. Rice,Patrick J. Biggs,Yasmin Hashim,Amanda Smith,Frances Connor,Adelgeir Arason,Julius Gudmundsson,David Ficenec,David P. Kelsell,D Ford,Patricia N. Tonin,D. Timothy Bishop,Nigel K. Spurr,Bruce A.J. Ponder,Rosalind A. Eeles,Julian Peto,Peter Devilee,Cees J. Cornelisse,Henry T. Lynch,Steven A. Narod,Gilbert M. Lenoir,Valdgardur Egilsson,Rosa Bjork Barkadottir,Douglas F. Easton,David R. Bentley,P. Andrew Futreal,Alan Ashworth,Michael R. Stratton +40 more
Journal ArticleDOI
Prevalence of BRCA1 and BRCA2 Gene Mutations in Patients With Early-Onset Breast Cancer
Julian Peto,N. Collins,Rita Barfoot,Sheila Seal,William H. Warren,Nazneen Rahman,Douglas F. Easton,Christopher H. Evans,Judith Deacon,Michael R. Stratton +9 more
TL;DR: Mutations in the BRCA1 and BRCa2 genes make approximately equal contributions to early-onset breast cancer in Britain and account for a small proportion of the familial risk of breast cancer.
Journal ArticleDOI
Instability of short tandem repeats (microsatellites) in human cancers
Richard Wooster,Anne-Marie Cleton-Jansen,N. Collins,Jonathon Mangion,R.S. Cornelis,Colin Cooper,Barry A. Gusterson,Bruce A.J. Ponder,A. von Deimling,Otmar D. Wiestler,Cees J. Cornelisse,Peter Devilee,Michael R. Stratton +12 more
TL;DR: The allele sizes of polymorphic microsatellite repeats in DNA from human cancers were compared to normal DNA from the same patients and evidence of an extra allele of a different size in the tumour which was not present in the normal DNA was found.