P
Patrick J. Biggs
Researcher at Massey University
Publications - 156
Citations - 7865
Patrick J. Biggs is an academic researcher from Massey University. The author has contributed to research in topics: Genome & Biology. The author has an hindex of 33, co-authored 133 publications receiving 6899 citations. Previous affiliations of Patrick J. Biggs include The Breast Cancer Research Foundation & Wellcome Trust Sanger Institute.
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Journal ArticleDOI
A conditional knockout resource for the genome-wide study of mouse gene function.
William C. Skarnes,Barry Rosen,Anthony P. West,Manousos Koutsourakis,Wendy Bushell,Vivek Iyer,Alejandro O. Mujica,Alejandro O. Mujica,Mark G. Thomas,Jennifer Harrow,Tony Cox,David A. Jackson,Jessica Severin,Jessica Severin,Patrick J. Biggs,Patrick J. Biggs,Jun Fu,Michael Nefedov,Pieter J. de Jong,A. Francis Stewart,Allan Bradley +20 more
TL;DR: High-throughput genome engineering highlighted by this study is broadly applicable to rat and human stem cells and provides a foundation for future genome-wide efforts aimed at deciphering the function of all genes encoded by the mammalian genome.
Journal ArticleDOI
SolexaQA: At-a-glance quality assessment of Illumina second-generation sequencing data
TL;DR: The SolexaQA package produces standardized outputs within minutes, thus facilitating ready comparison between flow cell lanes and machine runs, as well as providing immediate diagnostic information to guide the manipulation of sequence data for downstream analyses.
Journal ArticleDOI
Erratum: Identification of the breast cancer susceptibility gene BRCA2
Richard Wooster,Graham R. Bignell,Jonathan Lancaster,Sally Swift,Sheila Seal,Jonathan Mangion,N. Collins,Simon G. Gregory,Curtis Gumbs,Gos Michlem,Rita Barfoot,Rifat Hamoudi,Sandeep Patel,Catherine M. Rice,Patrick J. Biggs,Yasmin Hashim,Amanda Smith,Frances Connor,Adelgeir Arason,Julius Gudmundsson,David Ficenec,David P. Kelsell,D Ford,Patricia N. Tonin,D. Timothy Bishop,Nigel K. Spurr,Bruce A.J. Ponder,Rosalind A. Eeles,Julian Peto,Peter Devilee,Cees J. Cornelisse,Henry T. Lynch,Steven A. Narod,Gilbert M. Lenoir,Valdgardur Egilsson,Rosa Bjork Barkadottir,Douglas F. Easton,David R. Bentley,P. Andrew Futreal,Alan Ashworth,Michael R. Stratton +40 more
Journal ArticleDOI
Identification of the familial cylindromatosis tumour-suppressor gene.
Graham R. Bignell,William Warren,Sheila Seal,Meiko Takahashi,Elizabeth A. Rapley,Rita Barfoot,Helen Green,Carolanne Brown,Patrick J. Biggs,Sunil R. Lakhani,Chris Jones,Juliana E. Hansen,Edward Blair,B. Hofmann,Reiner Siebert,Gwen Turner,D. Gareth Evans,Connie Schrander-Stumpel,Frits A. Beemer,Ans M.W. van den Ouweland,Dicky J. J. Halley,Bertrand Delpech,Mark G. Cleveland,Irene M. Leigh,Jaakko Leisti,Sonja A. Rasmussen,Margaret R. Wallace,Christiane Fenske,Piu Banerjee,Naoki Oiso,Ranbir Chaggar,Samantha Merrett,N Leonard,Marcel Huber,Daniel Hohl,P Chapman,John Burn,Sally Swift,Anna Smith,Alan Ashworth,Michael R. Stratton +40 more
TL;DR: The susceptibility gene (CYLD) has been identified by detecting germline mutations in 21 cylindromatosis families and somatic mutations in 1 sporadic and 5 familialcylindromas, all mutations predict truncation or absence of the encoded protein.
Journal ArticleDOI
Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours.
Elizabeth A. Rapley,Gillian P. Crockford,Dawn Teare,Patrick J. Biggs,Sheila Seal,Rita Barfoot,S. Edwards,Rifat Hamoudi,Ketil Heimdal,Sophie D. Fosså,Katherine L. Tucker,Jenny Donald,Felicity Collins,Michael Friedlander,David Hogg,Paul E. Goss,Axel Heidenreich,Wilma Ormiston,Peter A. Daly,David Forman,R. Timothy D. Oliver,Michael Leahy,Robert Huddart,Colin Cooper,Julia G. Bodmer,Douglas F. Easton,Michael R. Stratton,D. Timothy Bishop +27 more
TL;DR: The results provide evidence for a TGCT susceptibility gene on chromosome Xq27 that may also predispose to UDT, and collected samples from 134 families with two or more cases of TGCT, 87 of which are affected sibpairs.