Erratum: Identification of the breast cancer susceptibility gene BRCA2
Richard Wooster,Graham R. Bignell,Jonathan Lancaster,Sally Swift,Sheila Seal,Jonathan Mangion,N. Collins,Simon G. Gregory,Curtis Gumbs,Gos Michlem,Rita Barfoot,Rifat Hamoudi,Sandeep Patel,Catherine M. Rice,Patrick J. Biggs,Yasmin Hashim,Amanda Smith,Frances Connor,Adelgeir Arason,Julius Gudmundsson,David Ficenec,David P. Kelsell,D Ford,Patricia N. Tonin,D. Timothy Bishop,Nigel K. Spurr,Bruce A.J. Ponder,Rosalind A. Eeles,Julian Peto,Peter Devilee,Cees J. Cornelisse,Henry T. Lynch,Steven A. Narod,Gilbert M. Lenoir,Valdgardur Egilsson,Rosa Bjork Barkadottir,Douglas F. Easton,David R. Bentley,P. Andrew Futreal,Alan Ashworth,Michael R. Stratton +40 more
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This article is published in Nature.The article was published on 1996-02-01 and is currently open access. It has received 970 citations till now. The article focuses on the topics: Breast cancer.read more
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Journal ArticleDOI
Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families
D Ford,Douglas F. Easton,Michael R. Stratton,Steven A. Narod,David E. Goldgar,Peter Devilee,D. T. Bishop,Barbara L. Weber,Gilbert M. Lenoir,Jenny Chang-Claude,Hagay Sobol,M D Teare,Jeffery P. Struewing,Adalgeir Arason,Siegfried Scherneck,Julian Peto,Timothy R. Rebbeck,Patricia N. Tonin,Susan L. Neuhausen,Rosa B. Barkardottir,Jorunn E. Eyfjord,Henry T. Lynch,Bruce A.J. Ponder,Simon A. Gayther,J.M. Birch,Annika Lindblom,Dominique Stoppa-Lyonnet,Y. J. Bignon,Åke Borg,U Hamann,Neva E. Haites,Rodney J. Scott,Christine Maugard,Hans F. A. Vasen,Susanne Seitz,Lisa A. Cannon-Albright,Andrew Craig Schofield,Moraima Zelada-Hedman +37 more
TL;DR: The lifetime risk of breast cancer appears similar to the risk in BRCA1 carriers, but there was some suggestion of a lower risk in bRCA2 carriers <50 years of age.
Journal ArticleDOI
Genome-wide association study identifies novel breast cancer susceptibility loci
Douglas F. Easton,Karen A. Pooley,Alison M. Dunning,Paul D.P. Pharoah,Deborah J. Thompson,Dennis G. Ballinger,Jeffery P. Struewing,Jonathan J. Morrison,Helen I. Field,Robert Luben,Nicholas J. Wareham,Shahana Ahmed,Catherine S. Healey,Richard Bowman,Kerstin B. Meyer,Christopher A. Haiman,Laurence K. Kolonel,Brian E. Henderson,Loic Le Marchand,Paul Brennan,Suleeporn Sangrajrang,Valerie Gaborieau,Fabrice Odefrey,Chen-Yang Shen,Pei-Ei Wu,Hui-Chun Wang,Diana Eccles,D. Gareth Evans,Julian Peto,Olivia Fletcher,Nichola Johnson,Sheila Seal,Michael R. Stratton,Nazneen Rahman,Georgia Chenevix-Trench,Georgia Chenevix-Trench,Stig E. Bojesen,Børge G. Nordestgaard,C K Axelsson,Montserrat Garcia-Closas,Louise A. Brinton,Stephen J. Chanock,Jolanta Lissowska,Beata Peplonska,Heli Nevanlinna,Rainer Fagerholm,H Eerola,Daehee Kang,Keun-Young Yoo,Dong-Young Noh,Sei Hyun Ahn,David J. Hunter,Susan E. Hankinson,David G. Cox,Per Hall,Sara Wedrén,Jianjun Liu,Yen-Ling Low,Natalia Bogdanova,Peter Schu¨rmann,Do¨rk Do¨rk,Rob A. E. M. Tollenaar,Catharina E. Jacobi,Peter Devilee,Jan G. M. Klijn,Alice J. Sigurdson,Michele M. Doody,Bruce H. Alexander,Jinghui Zhang,Angela Cox,Ian W. Brock,Gordon MacPherson,Malcolm W.R. Reed,Fergus J. Couch,Ellen L. Goode,Janet E. Olson,Hanne Meijers-Heijboer,Hanne Meijers-Heijboer,Ans M.W. van den Ouweland,André G. Uitterlinden,Fernando Rivadeneira,Roger L. Milne,Gloria Ribas,Anna González-Neira,Javier Benitez,John L. Hopper,Margaret R. E. McCredie,Margaret R. E. McCredie,Margaret R. E. McCredie,Melissa C. Southey,Melissa C. Southey,Graham G. Giles,Chris Schroen,Christina Justenhoven,Christina Justenhoven,Hiltrud Brauch,Hiltrud Brauch,Ute Hamann,Yon-Dschun Ko,Amanda B. Spurdle,Jonathan Beesley,Xiaoqing Chen,_ kConFab,Arto Mannermaa,Veli-Matti Kosma,Vesa Kataja,Jaana M. Hartikainen,Nicholas E. Day,David Cox,Bruce A.J. Ponder +109 more
TL;DR: To identify further susceptibility alleles, a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls was conducted, followed by a third stage in which 30 single nucleotide polymorphisms were tested for confirmation.
Journal ArticleDOI
BRCA1 and BRCA2: different roles in a common pathway of genome protection
TL;DR: The links between the two proteins must exist to explain the marked similarity of human cancer susceptibility that arises with germline mutations in these genes, and the proteins work in concert to protect the genome from double-strand DNA damage during DNA replication.
Journal ArticleDOI
BRCA1 and BRCA2 : 1994 and beyond
TL;DR: The discovery of the first gene associated with hereditary breast cancer, BRCA1, was anticipated to greatly increase the understanding of both hereditary and sporadic forms of breast cancers, and to lead to therapeutic and preventive breakthroughs.
Journal ArticleDOI
Breast cancer after prophylactic bilateral mastectomy in women with a BRCA1 or BRCA2 mutation
Hanne Meijers-Heijboer,Bert van Geel,Wim L.J. van Putten,Sonja C. Henzen-Logmans,Caroline Seynaeve,Marian B. E. Menke-Pluymers,C.C.M. Bartels,L.C. Verhoog,Ans M.W. van den Ouweland,Martinus F. Niermeijer,Cecile T. M. Brekelmans,Jan G. M. Klijn +11 more
TL;DR: In women with a BRCa1 or BRCA2 mutation, prophylactic bilateral total mastectomy reduces the incidence of breast cancer at three years of follow-up.
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