N
N.H. Gower
Researcher at University College London
Publications - 49
Citations - 3317
N.H. Gower is an academic researcher from University College London. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 20, co-authored 40 publications receiving 2724 citations. Previous affiliations of N.H. Gower include London Chest Hospital.
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Journal ArticleDOI
Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution
Nicholas McGranahan,Rachel Rosenthal,Crispin T. Hiley,Crispin T. Hiley,Andrew J. Rowan,Thomas B.K. Watkins,Gareth A. Wilson,Gareth A. Wilson,Nicolai Juul Birkbak,Nicolai Juul Birkbak,Selvaraju Veeriah,Peter Van Loo,Peter Van Loo,Javier Herrero,Charles Swanton,Charles Swanton,Mariam Jamal-Hanjani,Seema Shafi,Justyna Czyzewska-Khan,Diana Johnson,Joanne Laycock,Leticia Bosshard-Carter,Pat Gorman,Robert E. Hynds,Gareth A. Wilson,Stuart Horswell,Richard Mitter,Mickael Escudero,Aengus Stewart,Andrew Rowan,Hang Xu,Samra Turajlic,Crispin T. Hiley,Christopher Abbosh,Jacki Goldman,Richard Kevin Stone,Tamara Denner,Nik Matthews,Greg Elgar,Sophia Ward,Marta Costa,Sharmin Begum,Ben Phillimore,Tim Chambers,Emma Nye,Sofia Graca,Maise Al Bakir,Kroopa Joshi,Andrew Furness,Assma Ben Aissa,Yien Ning Sophia Wong,Andy Georgiou,Sergio A. Quezada,John A. Hartley,Helen Lowe,David Lawrence,Martin Hayward,Nikolaos Panagiotopoulos,Shyam Kolvekar,Mary Falzon,Elaine Borg,Teresa Marafioti,Celia Simeon,Gemma Hector,Amy Smith,Marie Aranda,Marco Novelli,Dahmane Oukrif,Sam M. Janes,Ricky Thakrar,Martin Forster,Tanya Ahmad,Siow Ming Lee,Dionysis Papadatos-Pastos,Dawn Carnell,Ruheena Mendes,Jeremy George,Neal Navani,Asia Ahmed,Magali Taylor,Junaid Choudhary,Yvonne Summers,Raffaele Califano,Paul D. Taylor,Rajesh Shah,Piotr Krysiak,Kendadai Rammohan,Eustace Fontaine,Richard Booton,Matthew Evison,Phil Crosbie,Stuart Moss,Faiza Idries,Leena Dennis Joseph,Paul N. Bishop,Anshuman Chaturved,Anne Marie Quinn,H. Doran,Angela Leek,Phil Harrison,Katrina Moore,Rachael Waddington,Juliette Novasio,Fiona H Blackhall,Jane Rogan,Elaine Smith,Caroline Dive,Jonathan Tugwood,Ged Brady,Dominic G. Rothwell,Francesca Chemi,Jackie Pierce,Sakshi Gulati,Babu Naidu,Gerald Langman,Simon Trotter,Mary Bellamy,Hollie Bancroft,Amy Kerr,Salma Kadiri,Joanne Webb,Gary Middleton,Madava Djearaman,Dean A. Fennell,Jacqui Shaw,John Le Quesne,David A. Moore,Apostolos Nakas,Sridhar Rathinam,William Monteiro,Hilary Marshall,Louise Nelson,Jonathan Bennett,Joan K. Riley,Lindsay Primrose,Luke Martinson,Girija Anand,Sajid A. Khan,Anita Amadi,Marianne Nicolson,Keith M. Kerr,Shirley Palmer,Hardy Remmen,Joy Miller,Keith Buchan,Mahendran Chetty,Lesley Gomersall,Jason F. Lester,A Edwards,Fiona Morgan,Haydn Adams,Helen Davies,Malgorzata Kornaszewska,Richard Attanoos,Sara Lock,Azmina Verjee,Mairead MacKenzie,Maggie Wilcox,Harriet Bell,Allan Hackshaw,Yenting Ngai,Sean W. Smith,N.H. Gower,Christian H. Ottensmeier,Serena Chee,Benjamin Johnson,Aiman Alzetani,Emily Shaw,Eric Lim,Paulo Loureiro de Sousa,Monica Tavares Barbosa,Alex Bowman,Simon Jordan,Alexandra Rice,H. Raubenheimer,Chiara Proli,Maria Elena Cufari,John Carlo Ronquillo,Angela Kwayie,Harshil Bhayani,Morag Hamilton,Yusura Bakar,Natalie Mensah,Lyn Ambrose,Anand Devaraj,Silviu Buderi,Jonathan Finch,Leire Azcarate,Hema Chavan,Sophie Green,Hillaria Mashinga,Andrew G. Nicholson,Kelvin Lau,Michael Sheaff,Peter Schmid,John Conibear,Veni Ezhil,Babikir Ismail,Melanie Irvin-Sellers,Vineet Prakash,Peter Russell,Teresa Light,Tracey Horey,Sarah Danson,Jonathan Bury,John G. Edwards,Jennifer Hill,S. Matthews,Yota Kitsanta,Kim Suvarna,Patricia Fisher,Allah Dino Keerio,Michael Shackcloth,John Gosney,Pieter E. Postmus,Sarah Feeney,Julius Asante-Siaw,Hugo J.W.L. Aerts,Stefan C. Dentro,Christophe Dessimoz +219 more
TL;DR: It is found that HLA LOH occurs in 40% of non-small-cell lung cancers (NSCLCs) and is associated with a high subclonal neoantigen burden, APOBEC-mediated mutagenesis, upregulation of cytolytic activity, and PD-L1 positivity.
Journal ArticleDOI
Mitomycin, Ifosfamide, and Cisplatin in Unresectable Non–Small-Cell Lung Cancer: Effects on Survival and Quality of Life
Michael Cullen,Lucinda Billingham,C.M. Woodroffe,A. D. Chetiyawardana,N.H. Gower,R. Joshi,D. R. Ferry,Robin M. Rudd,Stephen G. Spiro,J. E. Cook,C. Trask,E. Bessell,C. K. Connolly,Jeffrey S Tobias,Robert L. Souhami +14 more
TL;DR: In this paper, the authors describe the two largest reported, randomized, parallel trials designed to determine whether the addition of chemotherapy influences duration and quality of life in localized, unresectable (mitomycin, ifosfamide, cisplatin [MIC]1 trial) and extensive (MIC2 trial) disease.
Journal ArticleDOI
Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.
Frederick Arce Vargas,Andrew Furness,Andrew Furness,Isabelle Solomon,Kroopa Joshi,Kroopa Joshi,Leila Mekkaoui,Marta H. Lesko,Enrique Miranda Rota,Rony Dahan,Andrew Georgiou,Anna Sledzinska,Assma Ben Aissa,Dafne Franz,Mariana Werner Sunderland,Yien Ning Sophia Wong,Jake Y. Henry,Tim O'Brien,David Nicol,Ben Challacombe,Stephen A. Beers,Samra Turajlic,Martin Gore,James Larkin,Charles Swanton,Kerry A. Chester,Martin Pule,Jeffrey V. Ravetch,Teresa Marafioti,Karl S. Peggs,Sergio A. Quezada,Lavinia Spain,Andrew Wotherspoon,Nicholas Francis,Myles Smith,Dirk C. Strauss,Andrew J. Hayes,Aspasia Soultati,Mark Stares,Joanna Lynch,Nicos Fotiadis,Archana Fernando,Steve Hazell,Ashish Chandra,Lisa Pickering,Sarah Rudman,Simon Chowdhury,Mariam Jamal-Hanjani,Selvaraju Veeriah,Seema Shafi,Justyna Czyzewska-Khan,Diana Johnson,Joanne Laycock,Leticia Bosshard-Carter,Gerald Goh,Rachel Rosenthal,Pat Gorman,Nirupa Murugaesu,Robert E. Hynds,Gareth A. Wilson,Nicolai Juul Birkbak,Thomas B.K. Watkins,Nicholas McGranahan,Stuart Horswell,Richard Mitter,Mickael Escudero,Aengus Stewart,Peter Van Loo,Andrew Rowan,Hang Xu,Crispin T. Hiley,Christopher Abbosh,Jacki Goldman,Richard Kevin Stone,Tamara Denner,Nik Matthews,Greg Elgar,Sophia Ward,Jennifer Biggs,Marta Costa,Sharmin Begum,Ben Phillimore,Tim Chambers,Emma Nye,Sofia Graca,Maise Al Bakir,John A. Hartley,Helen Lowe,Javier Herrero,David Lawrence,Martin Hayward,Nikolaos Panagiotopoulos,Shyam Kolvekar,Mary Falzon,Elaine Borg,Celia Simeon,Gemma Hector,Amy Smith,Marie Aranda,Marco Novelli,Dahmane Oukrif,Sam M. Janes,Ricky Thakrar,Martin Forster,Tanya Ahmad,Siow Ming Lee,Dionysis Papadatos-Pastos,Dawn Carnell,Ruheena Mendes,Jeremy George,Neal Navani,Asia Ahmed,Magali Taylor,Junaid Choudhary,Yvonne Summers,Raffaele Califano,Paul D. Taylor,Rajesh Shah,Piotr Krysiak,Kendadai Rammohan,Eustace Fontaine,Richard Booton,Matthew Evison,Phil Crosbie,Stuart Moss,Faiza Idries,Leena Dennis Joseph,Paul N. Bishop,Anshuman Chaturved,Anne Marie Quinn,H. Doran,Angela Leek,Phil Harrison,Katrina Moore,Rachael Waddington,Juliette Novasio,Fiona H Blackhall,Jane Rogan,Elaine Smith,Caroline Dive,Jonathan Tugwood,Ged Brady,Dominic G. Rothwell,Francesca Chemi,Jackie Pierce,Sakshi Gulati,Babu Naidu,Gerald Langman,Simon Trotter,Mary Bellamy,Hollie Bancroft,Amy Kerr,Salma Kadiri,Joanne Webb,Gary Middleton,Madava Djearaman,Dean A. Fennell,Jacqui Shaw,John Le Quesne,David A. Moore,Apostolos Nakas,Sridhar Rathinam,William Monteiro,Hilary Marshall,Louise Nelson,Jonathan Bennett,Joan Riley,Lindsay Primrose,Luke Martinson,Girija Anand,Sajid A. Khan,Anita Amadi,Marianne Nicolson,Keith M. Kerr,Shirley Palmer,Hardy Remmen,Joy Miller,Keith Buchan,Mahendran Chetty,Lesley Gomersall,Jason F. Lester,A Edwards,Fiona Morgan,Haydn Adams,Helen Davies,Malgorzata Kornaszewska,Richard Attanoos,Sara Lock,Azmina Verjee,Mairead MacKenzie,Maggie Wilcox,Harriet Bell,Natasha Iles,Allan Hackshaw,Yenting Ngai,Sean W. Smith,N.H. Gower,Christian H. Ottensmeier,Serena Chee,Benjamin Johnson,Aiman Alzetani,Emily Shaw,Eric Lim,Paulo Loureiro de Sousa,Monica Tavares Barbosa,Alex Bowman,Simon Jorda,Alexandra Rice,H. Raubenheimer,Chiara Proli,Maria Elena Cufari,John Carlo Ronquillo,Angela Kwayie,Harshil Bhayani,Morag Hamilton,Yusura Bakar,Natalie Mensah,Lyn Ambrose,Anand Devaraj,Silviu Buderi,Jonathan Finch,Leire Azcarate,Hema Chavan,Sophie Green,Hillaria Mashinga,Andrew G. Nicholson,Kelvin Lau,Michael Sheaff,Peter Schmid,John Conibear,Veni Ezhil,Babikir Ismail,Melanie Irvin-Sellers,Vineet Prakash,Peter Russell,Teresa Light,Tracey Horey,Sarah Danson,Jonathan Bury,John G. Edwards,Jennifer Hill,S. Matthews,Yota Kitsanta,Kim Suvarna,Patricia Fisher,Allah Dino Keerio,Michael Shackcloth,John Gosney,Pieter E. Postmus,Sarah Feeney,Julius Asante-Siaw +250 more
TL;DR: Use of an anti‐CD25 antibody with enhanced binding to activating Fc&ggr;Rs led to effective depletion of tumor‐infiltrating Treg cells, increased effector to Treg cell ratios, and improved control of established tumors.
Journal ArticleDOI
Chemotherapy versus supportive care in advanced non-small cell lung cancer: improved survival without detriment to quality of life.
Stephen G. Spiro,Robin M. Rudd,Robert L. Souhami,Julia Brown,D.J. Fairlamb,N.H. Gower,L Maslove,Robert Milroy,Vicky Napp,Mahesh K. B. Parmar,M.D. Peake,Richard Stephens,H. Thorpe,David A. Waller,P West +14 more
TL;DR: The survival benefit seen in this trial was entirely consistent with the NSCLC meta-analysis and subsequent similarly designed large trials, and the regimens used proved to be cost effective, the extra cost of chemotherapy being offset by longer survival.
Journal ArticleDOI
Five-Day Oral Etoposide Treatment for Advanced Small-Cell Lung Cancer: Randomized Comparison With Intravenous Chemotherapy
Robert L. Souhami,Stephen G. Spiro,Robin M. Rudd,Mary-Carmen Ruiz de Elvira,LE James,N.H. Gower,Alan Lamont,Peter Harper +7 more
TL;DR: These interim results show that this schedule of oral etoposide is inferior to intravenous chemotherapy in the treatment of advanced SCLC and should not be used as first-line treatment of this disease.