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Aspasia Soultati
Researcher at Guy's and St Thomas' NHS Foundation Trust
Publications - 10
Citations - 1887
Aspasia Soultati is an academic researcher from Guy's and St Thomas' NHS Foundation Trust. The author has contributed to research in topics: Clear cell renal cell carcinoma & Metastasis. The author has an hindex of 6, co-authored 10 publications receiving 1302 citations. Previous affiliations of Aspasia Soultati include National Health Service & The Royal Marsden NHS Foundation Trust.
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Journal ArticleDOI
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal
Samra Turajlic,Samra Turajlic,Hang Xu,Kevin Litchfield,Andrew Rowan,Tim Chambers,José I. López,David Nicol,Tim O'Brien,James Larkin,Stuart Horswell,Mark Stares,Mark Stares,Lewis Au,Mariam Jamal-Hanjani,Ben Challacombe,Ashish Chandra,Steve Hazell,Claudia Eichler-Jonsson,Aspasia Soultati,Simon Chowdhury,Sarah Rudman,Joanna Lynch,Archana Fernando,Gordon Stamp,Emma Nye,Faiz Jabbar,Lavinia Spain,Sharanpreet Lall,Rosa Guarch,Mary Falzon,Ian Proctor,Lisa Pickering,Martin Gore,Thomas B.K. Watkins,Sophia Ward,Sophia Ward,Aengus Stewart,Renzo G. DiNatale,Maria F. Becerra,Ed Reznik,James J. Hsieh,Todd Richmond,George F. Mayhew,Samantha M. Hill,Catherine D. McNally,Carol Jones,Heidi Rosenbaum,Stacey Stanislaw,Daniel Burgess,Nelson Alexander,Charles Swanton,Charles Swanton +52 more
TL;DR: Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date, and 9p loss is identified as a highly selected event driving metastasis and ccRCC-related mortality.
Journal ArticleDOI
Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal
Samra Turajlic,Samra Turajlic,Hang Xu,Kevin Litchfield,Andrew Rowan,Stuart Horswell,Tim Chambers,Tim O'Brien,José I. López,Thomas B.K. Watkins,David Nicol,Mark Stares,Ben Challacombe,Steve Hazell,Ashish Chandra,Thomas J. Mitchell,Lewis Au,Claudia Eichler-Jonsson,Faiz Jabbar,Aspasia Soultati,Simon Chowdhury,Sarah Rudman,Joanna Lynch,Archana Fernando,Gordon Stamp,Emma Nye,Aengus Stewart,Wei Xing,Jonathan C. Smith,Mickael Escudero,Adam Huffman,Nik Matthews,Greg Elgar,Ben Phillimore,Marta Costa,Sharmin Begum,Sophia Ward,Sophia Ward,Max Salm,Stefan Boeing,Rosalie Fisher,Lavinia Spain,Carolina Navas,Eva Grönroos,Sebastijan Hobor,Sarkhara Sharma,Ismaeel Aurangzeb,Sharanpreet Lall,Alexander Polson,Mary Varia,Catherine Horsfield,Nicos Fotiadis,Lisa Pickering,Roland F. Schwarz,Bruno Silva,Javier Herrero,Nicholas M. Luscombe,Mariam Jamal-Hanjani,Rachel Rosenthal,Nicolai Juul Birkbak,Nicolai Juul Birkbak,Gareth A. Wilson,Gareth A. Wilson,Orsolya Pipek,Dezso Ribli,Marcin Krzystanek,István Csabai,Zoltan Szallasi,Zoltan Szallasi,Martin Gore,Nicholas McGranahan,Peter Van Loo,Peter Van Loo,Peter J. Campbell,James Larkin,Charles Swanton,Charles Swanton +76 more
TL;DR: The insights reconcile the variable clinical behavior of ccRCC and suggest evolutionary potential as a biomarker for both intervention and surveillance and identify genetic diversity and chromosomal complexity as determinants of patient outcome.
Journal ArticleDOI
Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal
Thomas J. Mitchell,Samra Turajlic,Andrew Rowan,David Nicol,James H.R. Farmery,Tim O'Brien,Inigo Martincorena,Patrick S. Tarpey,Nicos Angelopoulos,Lucy R. Yates,Adam Butler,Keiran Raine,Grant D. Stewart,Ben Challacombe,Archana Fernando,José I. López,Steve Hazell,Ashish Chandra,Simon Chowdhury,Sarah Rudman,Aspasia Soultati,Gordon Stamp,Nicos Fotiadis,Lisa Pickering,Lewis Au,Lavinia Spain,Joanna Lynch,Mark Stares,Jon W. Teague,Francesco Maura,David C. Wedge,Stuart Horswell,Tim Chambers,Kevin Litchfield,Hang Xu,Aengus Stewart,Reza Elaidi,Stéphane Oudard,Nicholas McGranahan,István Csabai,Martin Gore,P. Andrew Futreal,James Larkin,Andy G. Lynch,Zoltan Szallasi,Charles Swanton,Peter J. Campbell +46 more
TL;DR: Analysis of whole genomes from 95 biopsies across 33 patients with clear cell renal cell carcinoma suggests that the number of cells with 3p loss capable of initiating sporadic tumors is no more than a few hundred.
Journal ArticleDOI
Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.
Frederick Arce Vargas,Andrew Furness,Andrew Furness,Isabelle Solomon,Kroopa Joshi,Kroopa Joshi,Leila Mekkaoui,Marta H. Lesko,Enrique Miranda Rota,Rony Dahan,Andrew Georgiou,Anna Sledzinska,Assma Ben Aissa,Dafne Franz,Mariana Werner Sunderland,Yien Ning Sophia Wong,Jake Y. Henry,Tim O'Brien,David Nicol,Ben Challacombe,Stephen A. Beers,Samra Turajlic,Martin Gore,James Larkin,Charles Swanton,Kerry A. Chester,Martin Pule,Jeffrey V. Ravetch,Teresa Marafioti,Karl S. Peggs,Sergio A. Quezada,Lavinia Spain,Andrew Wotherspoon,Nicholas Francis,Myles Smith,Dirk C. Strauss,Andrew J. Hayes,Aspasia Soultati,Mark Stares,Joanna Lynch,Nicos Fotiadis,Archana Fernando,Steve Hazell,Ashish Chandra,Lisa Pickering,Sarah Rudman,Simon Chowdhury,Mariam Jamal-Hanjani,Selvaraju Veeriah,Seema Shafi,Justyna Czyzewska-Khan,Diana Johnson,Joanne Laycock,Leticia Bosshard-Carter,Gerald Goh,Rachel Rosenthal,Pat Gorman,Nirupa Murugaesu,Robert E. Hynds,Gareth A. Wilson,Nicolai Juul Birkbak,Thomas B.K. Watkins,Nicholas McGranahan,Stuart Horswell,Richard Mitter,Mickael Escudero,Aengus Stewart,Peter Van Loo,Andrew Rowan,Hang Xu,Crispin T. Hiley,Christopher Abbosh,Jacki Goldman,Richard Kevin Stone,Tamara Denner,Nik Matthews,Greg Elgar,Sophia Ward,Jennifer Biggs,Marta Costa,Sharmin Begum,Ben Phillimore,Tim Chambers,Emma Nye,Sofia Graca,Maise Al Bakir,John A. Hartley,Helen Lowe,Javier Herrero,David Lawrence,Martin Hayward,Nikolaos Panagiotopoulos,Shyam Kolvekar,Mary Falzon,Elaine Borg,Celia Simeon,Gemma Hector,Amy Smith,Marie Aranda,Marco Novelli,Dahmane Oukrif,Sam M. Janes,Ricky Thakrar,Martin Forster,Tanya Ahmad,Siow Ming Lee,Dionysis Papadatos-Pastos,Dawn Carnell,Ruheena Mendes,Jeremy George,Neal Navani,Asia Ahmed,Magali Taylor,Junaid Choudhary,Yvonne Summers,Raffaele Califano,Paul D. Taylor,Rajesh Shah,Piotr Krysiak,Kendadai Rammohan,Eustace Fontaine,Richard Booton,Matthew Evison,Phil Crosbie,Stuart Moss,Faiza Idries,Leena Dennis Joseph,Paul N. Bishop,Anshuman Chaturved,Anne Marie Quinn,H. Doran,Angela Leek,Phil Harrison,Katrina Moore,Rachael Waddington,Juliette Novasio,Fiona H Blackhall,Jane Rogan,Elaine Smith,Caroline Dive,Jonathan Tugwood,Ged Brady,Dominic G. Rothwell,Francesca Chemi,Jackie Pierce,Sakshi Gulati,Babu Naidu,Gerald Langman,Simon Trotter,Mary Bellamy,Hollie Bancroft,Amy Kerr,Salma Kadiri,Joanne Webb,Gary Middleton,Madava Djearaman,Dean A. Fennell,Jacqui Shaw,John Le Quesne,David A. Moore,Apostolos Nakas,Sridhar Rathinam,William Monteiro,Hilary Marshall,Louise Nelson,Jonathan Bennett,Joan Riley,Lindsay Primrose,Luke Martinson,Girija Anand,Sajid A. Khan,Anita Amadi,Marianne Nicolson,Keith M. Kerr,Shirley Palmer,Hardy Remmen,Joy Miller,Keith Buchan,Mahendran Chetty,Lesley Gomersall,Jason F. Lester,A Edwards,Fiona Morgan,Haydn Adams,Helen Davies,Malgorzata Kornaszewska,Richard Attanoos,Sara Lock,Azmina Verjee,Mairead MacKenzie,Maggie Wilcox,Harriet Bell,Natasha Iles,Allan Hackshaw,Yenting Ngai,Sean W. Smith,N.H. Gower,Christian H. Ottensmeier,Serena Chee,Benjamin Johnson,Aiman Alzetani,Emily Shaw,Eric Lim,Paulo Loureiro de Sousa,Monica Tavares Barbosa,Alex Bowman,Simon Jorda,Alexandra Rice,H. Raubenheimer,Chiara Proli,Maria Elena Cufari,John Carlo Ronquillo,Angela Kwayie,Harshil Bhayani,Morag Hamilton,Yusura Bakar,Natalie Mensah,Lyn Ambrose,Anand Devaraj,Silviu Buderi,Jonathan Finch,Leire Azcarate,Hema Chavan,Sophie Green,Hillaria Mashinga,Andrew G. Nicholson,Kelvin Lau,Michael Sheaff,Peter Schmid,John Conibear,Veni Ezhil,Babikir Ismail,Melanie Irvin-Sellers,Vineet Prakash,Peter Russell,Teresa Light,Tracey Horey,Sarah Danson,Jonathan Bury,John G. Edwards,Jennifer Hill,S. Matthews,Yota Kitsanta,Kim Suvarna,Patricia Fisher,Allah Dino Keerio,Michael Shackcloth,John Gosney,Pieter E. Postmus,Sarah Feeney,Julius Asante-Siaw +250 more
TL;DR: Use of an anti‐CD25 antibody with enhanced binding to activating Fc&ggr;Rs led to effective depletion of tumor‐infiltrating Treg cells, increased effector to Treg cell ratios, and improved control of established tumors.
Journal ArticleDOI
Global incidence and outcome of testicular cancer.
TL;DR: Testicular cancer is increasing in incidence in many countries; however, mortality rates remain low and most men are cured.