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Nan Shen
Researcher at Shanghai Jiao Tong University
Publications - 285
Citations - 17669
Nan Shen is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Systemic lupus erythematosus & Medicine. The author has an hindex of 56, co-authored 238 publications receiving 13592 citations. Previous affiliations of Nan Shen include University of Cincinnati Academic Health Center & Chinese Academy of Sciences.
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Journal Article
[Expression of fusion proteins in beta(2)GP I gene-transfected HEp-2 cells and its clinical application].
Liangjing Lu,Shunle Chen,Yue-ying Gu,Nan Shen,Chunde Bao,Yuan Wang,Chengde Yang,Ping Ye,Chong-zhao Yu +8 more
TL;DR: As a new kind of substrate of IIF, beta( 2)GP I transfectant can be used to detect anti-beta(2)GP-I antibodies and keep the immunofluorescent property of HEp-2 cells in IFANA test and can be use as substrate for routine IFANA detection.
Journal ArticleDOI
The microbiome in early life: implications for health outcomes
TL;DR: How prenatal and postnatal factors shape the development of both the microbiome and the immune system are described and the prospects of microbiome-mediated therapeutics and the need for more effective approaches that can reconfigure bacterial communities from pathogenic to homeostatic configurations are discussed.
Journal ArticleDOI
Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer
Maria Gloria Dominguez-Bello,Maria Gloria Dominguez-Bello,Kassandra M. De Jesús-Laboy,Nan Shen,Laura M. Cox,Amnon Amir,Antonio Gonzalez,Nicholas A. Bokulich,Se Jin Song,Se Jin Song,Marina Hoashi,Juana I Rivera-Viñas,Keimari Mendez,Rob Knight,Jose C. Clemente +14 more
TL;DR: It is demonstrated that vaginal microbes can be partially restored at birth in C-section–delivered babies.
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MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins.
Yuanjia Tang,Xiaobing Luo,Huijuan Cui,Xuming Ni,Min Yuan,Yanzhi Guo,Xinfang Huang,Haibo Zhou,Niek de Vries,Paul P. Tak,Shunle Chen,Nan Shen +11 more
TL;DR: Investigation of the contribution of microRNA-146a, identified in the pilot expression profiling step, to the pathogenesis of systemic lupus erythematosus revealed a negative regulator of innate immunity, which provides potential novel strategies for therapeutic intervention.
Journal ArticleDOI
The microbiome of uncontacted Amerindians
Jose C. Clemente,Erica C. Pehrsson,Martin J. Blaser,Martin J. Blaser,Kuldip Sandhu,Zhan Gao,Bin Wang,Magda Magris,Glida Hidalgo,Monica Contreras,Oscar Noya-Alarcon,Orlana Lander,Jeremy McDonald,Michael J. Cox,Jens Walter,Phaik Lyn Oh,Jean F. Ruiz,Selena Rodriguez,Nan Shen,Se Jin Song,Jessica L. Metcalf,Rob Knight,Rob Knight,Gautam Dantas,M. Gloria Dominguez-Bello,M. Gloria Dominguez-Bello,M. Gloria Dominguez-Bello +26 more
TL;DR: It is suggested that westernization significantly affects human microbiome diversity and that functional AR genes appear to be a feature of the human microbiome even in the absence of exposure to commercial antibiotics.