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Nancy L. Saccone
Researcher at Washington University in St. Louis
Publications - 133
Citations - 14273
Nancy L. Saccone is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Smoking cessation & Genome-wide association study. The author has an hindex of 46, co-authored 127 publications receiving 13022 citations. Previous affiliations of Nancy L. Saccone include Harvard University.
Papers
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Journal ArticleDOI
Current Smoking Raises Risk of Incident Hypertension: Hispanic Community Health Study-Study of Latinos.
Robert C. Kaplan,Robert C. Kaplan,Pedro L. Baldoni,Garrett Strizich,Eliseo J. Pérez-Stable,Nancy L. Saccone,Carmen A. Peralta,Krista M. Perreira,Marc D. Gellman,Jessica Williams-Nguyen,Carlos J. Rodriguez,David J. Lee,Martha L. Daviglus,Gregory A. Talavera,James P. Lash,Jianwen Cai,Nora Franceschini +16 more
TL;DR: It is confirmed that smoking constitutes a hypertension risk factor in Hispanic adults and a relatively modest cumulative dose of smoking, above 5 pack-years of exposure, raises risk of hypertension by over 30%.
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Genome screen for platelet monoamine oxidase (MAO) activity.
Nancy L. Saccone,John P. Rice,Nan Rochberg,Alison Goate,Theodore Reich,Shantia Shears,William Wu,John I. Nurnberger,Tatiana Foroud,Howard J. Edenberg,Ting-Kai Li +10 more
TL;DR: To identify loci involved in the control of platelet monoamine oxidase B (MAO-B) activity, a genomewide linkage screen was performed using 291 markers in 148 nuclear families containing a total of 1,008 nonindependent sib-pairs to provide consistency with linkage.
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Power-based, phase-informed selection of single nucleotide polymorphisms for disease association screens.
TL;DR: A novel power‐based algorithm to select a subset of tag SNPs for genotyping from a map of available SNPs, which incorporates information about the phase of LD observed among marker pairs to retain markers likely to be in coupling phase with an underlying disease locus, thus increasing power compared to a phase‐blind approach.
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A multi-incident, Old-Order Amish family with PD
Brad A. Racette,Melissa M. Rundle,Jen-Chyong Wang,Alison Goate,Nancy L. Saccone,Matthew J. Farrer,Sarah Lincoln,Jennifer Hussey,Scott Smemo,Jipeng Lin,B. Suarez,Abbas Parsian,Joel S. Perlmutter +12 more
TL;DR: PD in this community is more common than in the general population, and this increased prevalence may be due in part to a novel gene(s).
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Mapping genotype to phenotype for linkage analysis
TL;DR: Using simulated data from GAW11, categorical classification methods and neural network analysis are applied to model functions that use genetic information as input and trait information as output to understand genetic linkage in complex diseases.