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Nancy L. Saccone
Researcher at Washington University in St. Louis
Publications - 133
Citations - 14273
Nancy L. Saccone is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Smoking cessation & Genome-wide association study. The author has an hindex of 46, co-authored 127 publications receiving 13022 citations. Previous affiliations of Nancy L. Saccone include Harvard University.
Papers
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Journal ArticleDOI
Hereditary Vascular Retinopathy, Cerebroretinal Vasculopathy, and Hereditary Endotheliopathy with Retinopathy, Nephropathy, and Stroke Map to a Single Locus on Chromosome 3p21.1-p21.3
Roel A. Ophoff,Roel A. Ophoff,Joseph DeYoung,Marijke Joosse,Nathan A. Caffo,Lodewijk A. Sandkuijl,Gisela M. Terwindt,Joost Haan,Arn M. J. M. van den Maagdenberg,Joanna Jen,Robert W. Baloh,Maria-Louise Barilla-LaBarca,Nancy L. Saccone,John P. Atkinson,Michel D. Ferrari,Nelson B. Freimer,Rune R. Frants +16 more
TL;DR: It is shown that three autosomal dominant vasculopathy syndromes with prominent cerebroretinal manifestations map to the same 3-cM interval on 3p21, suggesting a common locus.
Journal ArticleDOI
Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin
Jen C. Wang,Anthony L. Hinrichs,Sarah Bertelsen,Heather Stock,John P. Budde,Danielle M. Dick,Kathleen K. Bucholz,John P. Rice,Nancy L. Saccone,Howard J. Edenberg,Victor Hesselbrock,Samuel Kuperman,Marc A. Schuckit,Laura J. Bierut,Alison Goate +14 more
TL;DR: Functional variants in both Tas2R16 and TAS2R38 correlate with alcohol consumption in African-American families, and it is found no evidence that TAS 2R38 haplotypes influence alcohol dependence in the COGA dataset.
Journal ArticleDOI
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans
Nancy L. Saccone,Tae-Hwi Schwantes-An,Jen C. Wang,Richard A. Grucza,Naomi Breslau,Dorothy K. Hatsukami,Eric O. Johnson,John P. Rice,Alison Goate,Laura J. Bierut +9 more
TL;DR: Several independent studies show that the chromosome 15q25.1 region, which contains the CHRNA5–CHRNA3–CHRNB4 gene cluster, harbors variants strongly associated with nicotine dependence, other smoking behaviors, lung cancer and chronic obstructive pulmonary disease.
Journal ArticleDOI
Evidence of CNIH3 involvement in opioid dependence
Elliot C. Nelson,Arpana Agrawal,Andrew C. Heath,Ryan Bogdan,Richard Sherva,Bo Zhang,Ream Al-Hasani,Michael R. Bruchas,Yi-Ling Chou,Catherine Demers,Caitlin E. Carey,Emily Drabant Conley,Amanda K. Fakira,Lindsay A. Farrer,Alison Goate,Scott D. Gordon,Anjali K. Henders,Victor Hesselbrock,Manav Kapoor,Michael T. Lynskey,Pamela A. F. Madden,Jose A. Morón,John P. Rice,Nancy L. Saccone,Sibylle G. Schwab,Fiona Shand,Alexandre A. Todorov,Leanne Wallace,Ting Wang,Naomi R. Wray,Xin Zhou,Louisa Degenhardt,Nicholas G. Martin,Ahmad R. Hariri,Henry R. Kranzler,Joel Gelernter,Laura J. Bierut,David J. Clark,Grant W. Montgomery +38 more
TL;DR: Findings support CNIH3 involvement in the pathophysiology of opioid dependence, complementing prior studies implicating the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate system.
Book ChapterDOI
Definition of the phenotype.
TL;DR: This chapter describes strategies to increase the power to detect susceptibility loci for complex diseases, and the effect of diagnostic and measurement error is discussed.