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Nancy L. Saccone
Researcher at Washington University in St. Louis
Publications - 133
Citations - 14273
Nancy L. Saccone is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Smoking cessation & Genome-wide association study. The author has an hindex of 46, co-authored 127 publications receiving 13022 citations. Previous affiliations of Nancy L. Saccone include Harvard University.
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Journal ArticleDOI
Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28.
Patricia Taillon-Miller,Irma Bauer-Sardiña,Nancy L. Saccone,Jenna Putzel,Tarja Laitinen,Antonio Cao,Juha Kere,Giuseppe Pilia,John P. Rice,Pui-Yan Kwok +9 more
TL;DR: A high-density SNP map of the Xq25–Xq28 region is constructed and male genotypes and haplotypes across this region for LD are analysed, suggesting that LD is not a monotonic function of the distance between markers, but is more a property of the particular location in the human genome.
Journal ArticleDOI
The CHRNA5-CHRNA3-CHRNB4 Nicotinic Receptor Subunit Gene Cluster Affects Risk for Nicotine Dependence in African-Americans and in European-Americans
Nancy L. Saccone,Jen C. Wang,Naomi Breslau,Eric O. Johnson,Dorothy K. Hatsukami,Scott F. Saccone,Richard A. Grucza,Lingwei Sun,Weimin Duan,John P. Budde,Robert Culverhouse,Louis Fox,Anthony L. Hinrichs,Joseph H. Steinbach,Meng Wu,John P. Rice,Alison Goate,Laura J. Bierut +17 more
TL;DR: It is shown that multiple variants in this gene cluster contribute to nicotine dependence risk, and some are also associated with functional effects on CHRNA5.
Journal ArticleDOI
Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression
Robert Culverhouse,Nancy L. Saccone,Amy C. Horton,Yinjiao Ma,Kaarin J. Anstey,Tobias Banaschewski,Margit Burmeister,Sarah Cohen-Woods,Bruno Etain,Helen L. Fisher,Noreen Goldman,Sébastien Guillaume,Sébastien Guillaume,John Horwood,Gabriella Juhasz,Kathryn J. Lester,Laura Mandelli,Christel M. Middeldorp,Emilie Olié,Emilie Olié,Sandra Villafuerte,Tracy Air,Ricardo Araya,Lucy Bowes,Richard Burns,Enda M. Byrne,Carolyn Coffey,William L. Coventry,Katerina A.B. Gawronski,Dana A. Glei,Alex Hatzimanolis,J-J Hottenga,Isabelle Jaussent,Catharine Jawahar,Christine Jennen-Steinmetz,John Kramer,Mohamed Lajnef,Keriann Little,H. M. Zu Schwabedissen,Matthias Nauck,Esther Nederhof,Peter Petschner,Wouter J. Peyrot,Christian Schwahn,Grant C.B. Sinnamon,David Stacey,Y. Tian,Catherine Toben,S Van der Auwera,Nicholas W.J. Wainwright,J. C. Wang,Gonneke Willemsen,Ian M. Anderson,Volker Arolt,Cecilia Åslund,Gyorgy Bagdy,Bernhard T. Baune,Frank Bellivier,Dorret I. Boomsma,Philippe Courtet,Philippe Courtet,Udo Dannlowski,E.J.C. de Geus,John Francis William Deakin,Simon Easteal,Thalia C. Eley,David M. Fergusson,Alison Goate,Xenia Gonda,Hans-Jörgen Grabe,C. Holzman,Eric O. Johnson,Martin A. Kennedy,Manfred Laucht,Nicholas G. Martin,Marcus R. Munafò,Kent W. Nilsson,Albertine J. Oldehinkel,Craig A. Olsson,Johan Ormel,Christian Otte,George C Patton,Brenda W.J.H. Penninx,Karen Ritchie,Marco Sarchiapone,J. M. Scheid,Alessandro Serretti,Jan Smit,Nicholas C. Stefanis,P. G. Surtees,Henry Völzke,Maxine Weinstein,Mary A. Whooley,John I. Nurnberger,Naomi Breslau,Laura J. Bierut +95 more
TL;DR: If an interaction exists in which the S allele of 5-HTTLPR increases risk of depression only in stressed individuals, then it is not broadly generalisable, but must be of modest effect size and only observable in limited situations.
Journal ArticleDOI
Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence
Jen-Chyong Wang,Richard A. Grucza,Carlos Cruchaga,Anthony L. Hinrichs,Sarah Bertelsen,John P. Budde,Louis Fox,E Goldstein,Oliver Reyes,Nancy L. Saccone,Scott F. Saccone,Xiaoling Xuei,K. K. Bucholz,Samuel Kuperman,Jr Ji Nurnberger,John P. Rice,Marc A. Schuckit,Jay A. Tischfield,Victor Hesselbrock,Bernice Porjesz,Howard J. Edenberg,Laura J. Bierut,Alison Goate +22 more
TL;DR: It is observed that a different group of polymorphisms, spanning CHRNA5-CHRNA3, demonstrate association with alcohol dependence defined by Diagnostic and Statistical Manual of Mental Disorders, 4th edn (DSM-IV) criteria.
Journal ArticleDOI
Multiple Distinct Risk Loci for Nicotine Dependence Identified by Dense Coverage of the Complete Family of Nicotinic Receptor Subunit (CHRN) Genes
Nancy L. Saccone,Scott F. Saccone,Anthony L. Hinrichs,Jerry A. Stitzel,Weimin Duan,Michele L. Pergadia,Arpana Agrawal,Naomi Breslau,Richard A. Grucza,Dorothy K. Hatsukami,Eric O. Johnson,Pamela A. F. Madden,Gary E. Swan,Jen C. Wang,Alison Goate,John P. Rice,Laura J. Bierut +16 more
TL;DR: This analysis reveals significant evidence for at least four distinct loci in the nicotinic receptor subunit genes that each influence the transition from smoking to nicotine dependence and may inform the development of improved smoking cessation treatments and prevention initiatives.