N
Nancy L. Saccone
Researcher at Washington University in St. Louis
Publications - 133
Citations - 14273
Nancy L. Saccone is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Smoking cessation & Genome-wide association study. The author has an hindex of 46, co-authored 127 publications receiving 13022 citations. Previous affiliations of Nancy L. Saccone include Harvard University.
Papers
More filters
Journal Article
A Risk Allele for Nicotine Dependence in CHRNA5 Is a Protective Allele for Cocaine Dependence. Commentary
Thorgeir E. Thorgeirsson,Kari Stefansson,Richard A. Grucza,Jen C. Wang,Jerry A. Stitzel,Anthony L. Hinrichs,Scott F. Saccone,Nancy L. Saccone,Kathleen K. Bucholz,C. Robert Cloninger,Rosalind J. Neuman,John P. Budde,Louis Fox,Sarah Bertelsen,John Kramer,Victor Hesselbrock,Jay A. Tischfield,John I. Nurnberger,Laura Almasy,Bernice Porjesz,Samuel Kuperman,Marc A. Schuckit,Howard J. Edenberg,John P. Rice,Alison Goate,Laura J. Bierut +25 more
TL;DR: The minor (A) allele of rs16969968, relative to the major G allele, appears to be both a risk factor for nicotine dependence and a protective factor for cocaine dependence.
Journal ArticleDOI
A Risk Allele for Nicotine Dependence in CHRNA5 Is a Protective Allele for Cocaine Dependence
Richard A. Grucza,Jen C. Wang,Jerry A. Stitzel,Anthony L. Hinrichs,Scott F. Saccone,Nancy L. Saccone,Kathleen K. Bucholz,C. Robert Cloninger,Rosalind J. Neuman,John P. Budde,Louis Fox,Sarah Bertelsen,John Kramer,Victor Hesselbrock,Jay A. Tischfield,John I. Nurnberger,Laura Almasy,Bernice Porjesz,Samuel Kuperman,Marc A. Schuckit,Howard J. Edenberg,John P. Rice,Alison Goate,Laura J. Bierut +23 more
TL;DR: A nonsynonymous coding polymorphism, rs16969968, of the CHRNA5 gene that encodes the alpha-5 subunit of the nicotinic acetylcholine receptor (nAChR) has been found to be associated with nicotine dependence.
Journal ArticleDOI
Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.
Dana B. Hancock,Yuelong Guo,Gunnar W Reginsson,Nathan C. Gaddis,Sharon M. Lutz,Richard Sherva,Anu Loukola,Camelia C. Minică,Christina A. Markunas,Younghun Han,Kendra A. Young,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Fangyi Gu,Daniel W. McNeil,Beenish Qaiser,Cristie Glasheen,S. Olson,M. T. Landi,P. A. F. Madden,Lindsay A. Farrer,Jacqueline M. Vink,Jacqueline M. Vink,Nancy L. Saccone,Michael C. Neale,Henry R. Kranzler,Henry R. Kranzler,James McKay,Rayjean J. Hung,Christopher I. Amos,Mary L. Marazita,Dorret I. Boomsma,Timothy B. Baker,Joel Gelernter,Jaakko Kaprio,Neil E. Caporaso,Thorgeir E. Thorgeirsson,John E. Hokanson,Laura J. Bierut,Kari Stefansson,Eric O. Johnson +40 more
TL;DR: The well-known CHRNA5-CHRNA3-CHRNB4 genes were reconfirmed and a novel association in the DNA methyltransferase gene DNMT3B yielded, which highlights the importance of genetically influenced regulation in brain on the risks of nicotine dependence, heavy smoking and consequent lung cancer.
Journal ArticleDOI
Endophenotypes Successfully Lead to Gene Identification: Results from the Collaborative Study on the Genetics of Alcoholism
Danielle M. Dick,Kevin A. Jones,Nancy L. Saccone,Anthony L. Hinrichs,Jen C. Wang,Alison Goate,Laura J. Bierut,Laura Almasy,Marc A. Schuckit,Victor Hesselbrock,Jay A. Tischfield,Tatiana Foroud,Howard J. Edenberg,Bernice Porjesz,Henri Begleiter +14 more
TL;DR: The results provide an illustration of the successful use of endophenotypes to identify genes involved in the predisposition to a complex psychiatric phenotype, a strategy originally proposed by Gottesman and Shields in 1972.
Journal ArticleDOI
A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence.
Laura J. Bierut,John P. Rice,Alison Goate,Anthony L. Hinrichs,Nancy L. Saccone,Tatiana Foroud,Howard J. Edenberg,C. Robert Cloninger,Henri Begleiter,P. Michael Conneally,Raymond R. Crowe,Victor Hesselbrock,Ting-Kai Li,John I. Nurnberger,Bernice Porjesz,Marc A. Schuckit,Theodore Reich +16 more
TL;DR: There is evidence of specific genetic regions involved in the development of habitual smoking and not alcohol dependence, and there is also evidence of an area on chromosome 2 that may reflect a common genetic vulnerability locus to both habitualsmoking and alcohol dependence.