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Nancy L. Saccone
Researcher at Washington University in St. Louis
Publications - 133
Citations - 14273
Nancy L. Saccone is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Smoking cessation & Genome-wide association study. The author has an hindex of 46, co-authored 127 publications receiving 13022 citations. Previous affiliations of Nancy L. Saccone include Harvard University.
Papers
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Journal ArticleDOI
Leveraging Genomic Data in Smoking Cessation Trials in the Era of Precision Medicine: Why and How.
Li-Shiun Chen,Laurie Zawertailo,Thomas M. Piasecki,Jaakko Kaprio,Marilyn G. Foreman,Hannah R Elliott,Sean P. David,Andrew W. Bergen,James W. Baurley,Rachel F. Tyndale,Timothy B. Baker,Laura J. Bierut,Nancy L. Saccone,Tobacco (Srnt) +13 more
TL;DR: The goal is to encourage and provide support for treatment researchers to consider biosample collection and genotyping their existing samples as well as integrating genetic analyses into their study design in order to realize precision medicine in treatment of nicotine dependence.
Journal ArticleDOI
The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings
Nancy L. Saccone,James W. Baurley,Andrew W. Bergen,Sean P. David,Hannah R Elliott,Marilyn G. Foreman,Jaakko Kaprio,Thomas M. Piasecki,Caroline L Relton,Laurie Zawertailo,Laura J. Bierut,Rachel F. Tyndale,Li-Shiun Chen +12 more
TL;DR: In this paper, the authors reviewed several compelling genetic and biomarker findings related to smoking cessation and treatment and provided practical guidance on how to incorporate biosample collection into a planned clinical trial and discussed avenues for harmonizing data and fostering consortium-based collaborative research on the pharmacogenomics of smoking cessation.
Journal ArticleDOI
Nicotine Dependence and Comorbid Psychiatric Disorders: Examination of Specific Genetic Variants in the CHRNA5-A3-B4 Nicotinic Receptor Genes
Li-Shiun Chen,Hong Xian,Richard A. Grucza,Nancy L. Saccone,Jen C. Wang,Eric O. Johnson,Naomi Breslau,Dorothy K. Hatsukami,Laura J. Bierut +8 more
TL;DR: The genetic risks of nicotine dependence associated with the CHRNA5-A3-B4 subunit genes are specific, and not shared among commonly comorbid psychiatric disorders.
Journal ArticleDOI
Use of polygenic risk scores of nicotine metabolism in predicting smoking behaviors
TL;DR: Results suggest that nicotine metabolism PRSs based on GWAS meta-analyses predict an individual's nicotine metabolism, so does use of the top hit variant.