K
Kuntal Pal
Researcher at Van Andel Institute
Publications - 29
Citations - 1549
Kuntal Pal is an academic researcher from Van Andel Institute. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 9, co-authored 14 publications receiving 1218 citations. Previous affiliations of Kuntal Pal include Adamas University & National University of Singapore.
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Journal ArticleDOI
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
Yanyong Kang,X. Edward Zhou,Xiang Gao,Yuanzheng He,Wei Liu,Andrii Ishchenko,Anton Barty,Thomas A. White,Oleksandr Yefanov,Gye Won Han,Qingping Xu,Parker W. de Waal,Jiyuan Ke,M. H. Eileen Tan,Chenghai Zhang,Arne Moeller,Graham M. West,Bruce D. Pascal,Ned Van Eps,Lydia N. Caro,Sergey A. Vishnivetskiy,Regina J. Lee,Kelly Suino-Powell,Xin Gu,Kuntal Pal,Jinming Ma,Xiaoyong Zhi,Sébastien Boutet,Garth J. Williams,Marc Messerschmidt,Cornelius Gati,Nadia A. Zatsepin,Dingjie Wang,Daniel James,Shibom Basu,Shatabdi Roy-Chowdhury,Chelsie E. Conrad,Jesse Coe,Haiguang Liu,Stella Lisova,Christopher Kupitz,Ingo Grotjohann,Raimund Fromme,Yi Jiang,Minjia Tan,Huaiyu Yang,Jun Li,Meitian Wang,Zhong Zheng,Dianfan Li,Nicole Howe,Yingming Zhao,Jörg Standfuss,Kay Diederichs,Yuhui Dong,Clinton S. Potter,Bridget Carragher,Martin Caffrey,Hualiang Jiang,Henry N. Chapman,John C. H. Spence,Petra Fromme,Uwe Weierstall,Oliver P. Ernst,Vsevolod Katritch,Vsevolod V. Gurevich,Patrick R. Griffin,Wayne L. Hubbell,Raymond C. Stevens,Vadim Cherezov,Karsten Melcher,H. Eric Xu +71 more
TL;DR: The crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin is determined by serial femtosecond X-ray laser crystallography and provides a basis for understanding GPCR-mediated arrestin-biased signalling.
Journal ArticleDOI
Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors
X. Edward Zhou,X. Edward Zhou,Yuanzheng He,Parker W. de Waal,Xiang Gao,Yanyong Kang,Ned Van Eps,Yanting Yin,Yanting Yin,Kuntal Pal,Devrishi Goswami,Thomas A. White,Anton Barty,Naomi R. Latorraca,Henry N. Chapman,Wayne L. Hubbell,Ron O. Dror,Raymond C. Stevens,Raymond C. Stevens,Vadim Cherezov,Vsevolod V. Gurevich,Patrick R. Griffin,Oliver P. Ernst,Karsten Melcher,H. Eric Xu,H. Eric Xu +25 more
TL;DR: An X-ray free electron laser (XFEL) crystal structure of the rhodopsin-arrestin complex is reported, in which the phosphorylated C terminus of r Rhodopsin forms an extended intermolecular β sheet with the N-terminal β strands of arrestin.
Journal ArticleDOI
A complex structure of arrestin-2 bound to a G protein-coupled receptor.
Wanchao Yin,Zhihai Li,Mingliang Jin,Yanting Yin,P.W. de Waal,Kuntal Pal,Kuntal Pal,Yulong Yin,Yulong Yin,Xiang Gao,Yuanzheng He,Yuanzheng He,Jing Gao,Xiaoxi Wang,Yan Zhang,Hu Zhou,Karsten Melcher,Yi Jiang,Yao Cong,X. Edward Zhou,Xuekui Yu,H. Eric Xu,H. Eric Xu +22 more
TL;DR: The structure of Arr2 in complex with neurotensin receptor 1 (NTSR1) is reported, which reveals an overall assembly that is strikingly different from the visual arrestin–rhodopsin complex by a 90° rotation of ArR2 relative to the receptor.
Journal ArticleDOI
Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors
TL;DR: The general structural principles that guide hormone binding by Class B ECDs are summarized and their implications in the design of peptide hormone analogs for therapeutic purposes are summarized.
Journal ArticleDOI
Structural Basis for Hormone Recognition by the Human CRFR2α G Protein-coupled Receptor
TL;DR: The purified N-terminal extracellular domains of human CRFR1 and the CRFR2α isoform are sufficient to discriminate the peptides and provide a molecular template for the rational design of therapeutic agents selectively targeting these receptors.