Shunichi Ariizumi

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: The whole-genome sequencing analysis of HCCs identified the influence of etiological background on somatic mutation patterns and subsequent carcinogenesis, as well as recurrent mutations in chromatin regulators in H CCs.

TL;DR: In this article, a comprehensive analysis identified point mutations, structural variations (STVs), and virus integrations, in noncoding and coding regions of 300 liver cancers from Japanese individuals.

TL;DR: Large-scale genome sequencing analyses on biliary tract cancers suggest cell-of-origin predictions using WGS and epigenetic features suggest hepatocyte-origin of hepatitis-related ICCs, and these findings could be useful to establish treatment and diagnostic strategies for BTCs based on genetic information.

TL;DR: The genome-wide substitution patterns of LCBs developed in chronic hepatitis livers overlapped with those of 60 HCCs, whereas those of hepatitis-negative LCBs diverged, revealing the strong impact of chronic hepatitis on the mutational landscape in liver cancer and the genetic diversity among LCBs.