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Narayanaiah Cheedarla
Researcher at Emory University
Publications - 37
Citations - 300
Narayanaiah Cheedarla is an academic researcher from Emory University. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 5, co-authored 14 publications receiving 92 citations. Previous affiliations of Narayanaiah Cheedarla include Yerkes National Primate Research Center & Indian Council of Medical Research.
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Journal ArticleDOI
Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy.
Hemalatha Babu,Hemalatha Babu,Anoop T. Ambikan,Erin E. Gabriel,Sara Svensson Akusjärvi,Alangudi Natarajan Palaniappan,Vijila Sundaraj,Naveen Reddy Mupanni,Maike Sperk,Narayanaiah Cheedarla,Rathinam Sridhar,Srikanth Tripathy,Piotr Nowak,Luke Elizabeth Hanna,Ujjwal Neogi +14 more
TL;DR: Evaluated the levels of systemic inflammation and understand the risk of age-associated diseases in PLHIV on long-term suppressive ART using a large number of biomarkers of inflammation and immune activation to highlight the need for enhanced treatment monitoring and special interventions in HIV-infected individuals.
Journal ArticleDOI
SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung.
Nanda Kishore Routhu,Narayanaiah Cheedarla,Venkata S. Bollimpelli,Sailaja Gangadhara,Venkata Viswanadh Edara,Lilin Lai,Anusmita Sahoo,Ayalnesh Shiferaw,Tiffany M. Styles,Katharine Floyd,Stephanie Fischinger,Caroline Atyeo,Sally Shin,Sanjeev Gumber,Shannon Kirejczyk,Kenneth H. Dinnon,Pei Yong Shi,Vineet D. Menachery,Mark A. Tomai,Christopher B. Fox,Galit Alter,Thomas H. Vanderford,Lisa E. Gralinski,Mehul S. Suthar,Rama Rao Amara +24 more
TL;DR: In this article, a trimeric form of the spike protein was developed and showed that it induces a potent neutralizing antibody response against live virus with diverse effector functions and provides protection against SARS-CoV-2 challenge in mice and rhesus macaques.
Journal ArticleDOI
A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs.
Nanda Kishore Routhu,Narayanaiah Cheedarla,Narayanaiah Cheedarla,Sailaja Gangadhara,Sailaja Gangadhara,Venkata S. Bollimpelli,Venkata S. Bollimpelli,Arun K. Boddapati,Ayalnesh Shiferaw,Ayalnesh Shiferaw,Sheikh Abdul Rahman,Sheikh Abdul Rahman,Anusmita Sahoo,Anusmita Sahoo,Venkata Viswanadh Edara,Lilin Lai,Lilin Lai,Katharine Floyd,Katharine Floyd,Shelly Wang,Stephanie Fischinger,Caroline Atyeo,Sally Shin,Sanjeev Gumber,Shannon Kirejczyk,Joyce Cohen,Sherrie Jean,Jennifer S. Wood,Fawn Connor-Stroud,Rachelle L. Stammen,Amit A. Upadhyay,Kathryn L. Pellegrini,David C. Montefiori,Pei Yong Shi,Vineet D. Menachery,Galit Alter,Thomas H. Vanderford,Steven E. Bosinger,Steven E. Bosinger,Mehul S. Suthar,Mehul S. Suthar,Rama Rao Amara,Rama Rao Amara +42 more
TL;DR: In this article, modified vaccinia Ankara (MVA) vectors expressing membrane-anchored pre-fusion stabilized spike (mVA/S) but not secreted S1 induced strong neutralizing antibody responses against SARS-CoV-2 in mice.
Journal ArticleDOI
Sequence insertions in the HIV type 1 subtype C viral promoter predominantly generate an additional NF-κB binding site.
Mahesh Bachu,Anil Babu Mukthey,Rajesh V. Murali,Narayanaiah Cheedarla,Anita Mahadevan,Susarla K. Shankar,Kadappa Shivappa Satish,Tapas K. Kundu,Udaykumar Ranga +8 more
TL;DR: A subset of viral strains containing sequence insertions upstream of the viral enhancer has been identified and NF-κB acquisition appears to be the most common phenotype unique for HIV-1 subtype C with nearly half of the variant strains containing such insertions.
Journal ArticleDOI
Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody
Sanjeev Kumar,Anamika Patel,Lilin Lai,Chennareddy Chakravarthy,Rajesh M. Valanparambil,Elluri Seetharami Reddy,Kamalvishnu P. Gottimukkala,Meredith E. Davis-Gardner,Venkata Viswanadh Edara,Susanne L. Linderman,Kaustuv Nayak,Kritika Dixit,Pragati Sharma,Prashant Kumar Bajpai,Vanshika Singh,Filipp Frank,Narayanaiah Cheedarla,Hans Verkerke,Andrew S. Neish,John D. Roback,Grace Mantus,Pawan Goel,Manju Rahi,Carl W. Davis,Jens Wrammert,Sucheta Godbole,Amy R. Henry,Daniel C. Douek,Mehul S. Suthar,Rafi Ahmed,Eric A. Ortlund,Amit Sharma,Kaja Murali-Krishna,Anmol Chandele +33 more
TL;DR: A receptor binding domain (RBD)–specific mAb 002-S21F2 that has rare gene usage and potently neutralized live viral isolates of SARS-CoV-2 variants including Omicron sublineages is found by characterizing several human monoclonal antibodies isolated from single B cells of the COVID-19–recovered individuals in India.