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Natascia Sestu
Researcher at National Institutes of Health
Publications - 3
Citations - 876
Natascia Sestu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Genome-wide association study & Fetal hemoglobin. The author has an hindex of 3, co-authored 3 publications receiving 812 citations.
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Journal ArticleDOI
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia
Manuela Uda,Renzo Galanello,Serena Sanna,Guillaume Lettre,Guillaume Lettre,Vijay G. Sankaran,Wei-Min Chen,Gianluca Usala,Fabio Busonero,Andrea Maschio,Giuseppe Albai,Maria Grazia Piras,Natascia Sestu,Sandra Lai,Mariano Dei,Antonella Mulas,Laura Crisponi,Silvia Naitza,Isadora Asunis,Manila Deiana,Ramaiah Nagaraja,Lucia Perseu,Stefania Satta,Maria Dolores Cipollina,Carla Sollaino,Paolo Moi,Joel N. Hirschhorn,Joel N. Hirschhorn,Stuart H. Orkin,G. Abecasis,David Schlessinger,Antonio Cao +31 more
TL;DR: It is indicated that BCL11A variants, by modulating HbF levels, act as an important ameliorating factor of the β-thalassemia phenotype, and it is likely they could helpAmeliorate other hemoglobin disorders.
Journal ArticleDOI
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.
Wei-Min Chen,Michael R. Erdos,Anne U. Jackson,Richa Saxena,Serena Sanna,Serena Sanna,Kristi D. Silver,Nicholas J. Timpson,Torben Hansen,Marco Orrù,Maria Grazia Piras,Lori L. Bonnycastle,Cristen J. Willer,Valeriya Lyssenko,Haiqing Shen,Johanna Kuusisto,Shah Ebrahim,Natascia Sestu,William L. Duren,Maria Cristina Spada,Heather M. Stringham,Laura J. Scott,Nazario Olla,Amy J. Swift,Samer S. Najjar,Braxton D. Mitchell,Debbie A Lawlor,George Davey Smith,Yoav Ben-Shlomo,Gitte Andersen,Knut Borch-Johnsen,Torben Jørgensen,Jouko Saramies,Timo T. Valle,Timo T. Valle,Thomas A. Buchanan,Alan R. Shuldiner,Edward G. Lakatta,Richard N. Bergman,Manuela Uda,Jaakko Tuomilehto,Jaakko Tuomilehto,Oluf Pedersen,Oluf Pedersen,Antonio Cao,Leif Groop,Karen L. Mohlke,Markku Laakso,David Schlessinger,Francis S. Collins,David Altshuler,Gonçalo R. Abecasis,Michael Boehnke,Angelo Scuteri,Richard M. Watanabe +54 more
TL;DR: The results in combination with data reported in the literature suggest that G6PC2, a glucose-6-phosphatase almost exclusively expressed in pancreatic islet cells, may underlie variation in fasting glucose, though it is possible that ABCB11, which is expressed primarily in liver, may also contribute to such variation.
Journal ArticleDOI
Phosphodiesterase 8B Gene Variants Are Associated with Serum TSH Levels and Thyroid Function
Lisette Arnaud-Lopez,Gianluca Usala,Graziano Ceresini,Braxton D. Mitchell,Maria Grazia Pilia,Maria Grazia Piras,Natascia Sestu,Andrea Maschio,Fabio Busonero,Giuseppe Albai,Mariano Dei,Sandra Lai,Antonella Mulas,Laura Crisponi,Toshiko Tanaka,Stefania Bandinelli,Jack M. Guralnik,Angela Loi,Lenuta Balaci,Gabriella Sole,Alessia Prinzis,Stefano Mariotti,Alan R. Shuldiner,Alan R. Shuldiner,Antonio Cao,David Schlessinger,Manuela Uda,Gonçalo R. Abecasis,Ramaiah Nagaraja,Serena Sanna,Silvia Naitza +30 more
TL;DR: The results suggest a primary effect of PDE8B variants on cAMP levels in the thyroid, which would affect production of T4 and T3 and feedback to alter TSH release by the pituitary.