Nicola Zanesi

TL;DR: The enforced expression of miR-29s in lung cancer cell lines restores normal patterns of DNA methylation, induces reexpression of methylation-silenced tumor suppressor genes, and inhibits tumorigenicity in vitro and in vivo.

TL;DR: It is shown that tumor-secreted miR-21 andmiR-29a also can function by another mechanism, by binding as ligands to receptors of the Toll-like receptor (TLR) family, murine TLR7 and human TLR8, in immune cells, triggering a TLR-mediated prometastatic inflammatory response that ultimately may lead to tumor growth and metastasis.

TL;DR: A high-throughput profiling of genes modulated by miR-15a/16-1 in a leukemic cell line model (MEG-01) and in primary CLL samples is produced and a significant enrichment in cancer genes that directly or indirectly affect apoptosis and cell cycle was found.

TL;DR: A MM miRNA signature is described, which includes miRNAs that modulate the expression of proteins critical to myeloma pathogenesis that were shown to down regulate expression of SOCS-1 and miR-19a and 19b.

TL;DR: The data support a tumor suppressor role for miR-29 and provide a rationale for the use of synthetic mi R-29b oligonucleotides as a novel strategy to improve treatment response in AML.