N
Nicolas Collin
Researcher at National Institutes of Health
Publications - 8
Citations - 442
Nicolas Collin is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Salivary gland & Leishmania. The author has an hindex of 5, co-authored 8 publications receiving 405 citations. Previous affiliations of Nicolas Collin include University of Lausanne.
Papers
More filters
Journal ArticleDOI
Sand Fly Salivary Proteins Induce Strong Cellular Immunity in a Natural Reservoir of Visceral Leishmaniasis with Adverse Consequences for Leishmania
Nicolas Collin,Regis Gomes,Clarissa Teixeira,Lily I. Cheng,Andre Laughinghouse,Jerrold M. Ward,Dia Eldin Elnaiem,Laurent Fischer,Jesus G. Valenzuela,Shaden Kamhawi +9 more
TL;DR: Certain sand fly salivary proteins are potent immunogens obligatorily co-deposited with Leishmania parasites during transmission and their inclusion in an anti-Leishmania vaccine would exploit anti-saliva immunity following an infective sand fly bite and set the stage for a protective anti- leishmania immune response.
Journal ArticleDOI
Discovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasi in Latin America.
Clarissa Teixeira,Regis Gomes,Nicolas Collin,David Reynoso,Ryan C. Jochim,Fabiano Oliveira,Amy E. Seitz,Dia-Eldin A. Elnaiem,Arlene de Jesus Mendes Caldas,Ana Paula de Souza,Cláudia Brodskyn,Ivete Lopes de Mendonça,Carlos Henrique Nery Costa,Petr Volf,Aldina Barral,Shaden Kamhawi,Jesus G. Valenzuela +16 more
TL;DR: Salivary recombinant proteins are of value as markers of vector exposure in humans and of sand fly exposure in dogs.
Journal ArticleDOI
Structure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection.
Xueqing Xu,Fabiano Oliveira,B.W. Chang,Nicolas Collin,Nicolas Collin,Regis Gomes,Clarissa Teixeira,David Reynoso,Van My Pham,Dia Eldin Elnaiem,Dia Eldin Elnaiem,Shaden Kamhawi,José M. C. Ribeiro,Jesus G. Valenzuela,John F. Andersen +14 more
TL;DR: It is demonstrated that LJM11 confers protective immunity against Leishmania major infection and correlates with a strong induction of a delayed type hypersensitivity (DTH) response following exposure to L. longipalpis saliva.
Journal ArticleDOI
Lufaxin, a Novel Factor Xa Inhibitor From the Salivary Gland of the Sand Fly Lutzomyia longipalpis, Blocks Protease-Activated Receptor 2 Activation and Inhibits Inflammation and Thrombosis In Vivo
Nicolas Collin,Teresa C.F. Assumpção,Daniella M. Mizurini,Dana C. Gilmore,Angélica Dutra-Oliveira,Michalis Kotsyfakis,Anderson Sá-Nunes,Clarissa Teixeira,José M. C. Ribeiro,Robson Q. Monteiro,Jesus G. Valenzuela,Ivo M.B. Francischetti +11 more
TL;DR: Salivary gland of sand flies was found to inhibit FXa and to interact with the enzyme, and Lufaxin belongs to a novel family of slow-tight FXa inhibitors, which display antithrombotic and anti-inflammatory activities.
Journal ArticleDOI
Immunogenic salivary proteins of Triatoma infestans: development of a recombinant antigen for the detection of low-level infestation of triatomines.
Alexandra Schwarz,Alexandra Schwarz,Stefan Helling,Nicolas Collin,Clarissa Teixeira,Nora Medrano-Mercado,Jen C. C. Hume,Teresa C.F. Assumpção,Katrin Marcus,Christian Stephan,Helmut E. Meyer,José M. C. Ribeiro,Peter F. Billingsley,Jesus G. Valenzuela,Jeremy M Sternberg,Guenter A. Schaub +15 more
TL;DR: The recombinant rTiSP14.6 is a suitable and promising epidemiological marker for detecting the presence of small numbers of different species of triatomines and could be developed for use as a new tool in surveillance programs, especially to corroborate vector elimination in Chagas disease vector control campaigns.