N
Nicole L. Rosin
Researcher at University of Calgary
Publications - 34
Citations - 1235
Nicole L. Rosin is an academic researcher from University of Calgary. The author has contributed to research in topics: Wound healing & Medicine. The author has an hindex of 15, co-authored 24 publications receiving 810 citations. Previous affiliations of Nicole L. Rosin include University of British Columbia & Dalhousie University.
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Journal ArticleDOI
Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells
Genc Basha,Tatiana Novobrantseva,Nicole L. Rosin,Yuen Yi C. Tam,Ismail M. Hafez,Matthew K Wong,Tsukasa Sugo,Vera M. Ruda,June Qin,Boris Klebanov,Marco A. Ciufolini,Akin Akinc,Ying K. Tam,Michael J. Hope,Pieter R. Cullis +14 more
TL;DR: In vivo results showed that LNP siRNA systems containing DLinKC2-DMA are effective agents for silencing GAPDH in APCs in the spleen and peritoneal cavity following systemic administration.
Journal ArticleDOI
Macrophages Regulate Schwann Cell Maturation after Nerve Injury.
Jo Anne Stratton,Alexandra Holmes,Nicole L. Rosin,Sarthak Sinha,Mohit Vohra,Nicole E. Burma,Tuan Trang,Rajiv Midha,Jeff Biernaskie,Jeff Biernaskie +9 more
TL;DR: It is demonstrated that after injury, including in humans, macrophages function to clear debris and persist within the nerve microenvironment and highlight a molecular mechanism by which this occurs.
Journal ArticleDOI
Imaging Collagen in Scar Tissue: Developments in Second Harmonic Generation Microscopy for Biomedical Applications.
TL;DR: An extensive review of studies that have used second harmonic generation imaging in skin, lung, cardiovascular, tendon and ligaments, and eye tissue to understand alterations in fibrillar collagens in scar tissue and the current methods of image analysis are reviewed.
Journal ArticleDOI
Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing
Sepideh Abbasi,Sarthak Sinha,Elodie Labit,Nicole L. Rosin,Grace Yoon,Waleed Rahmani,Arzina Jaffer,Nilesh Sharma,Andrew Hagner,Prajay Shah,Rohit Arora,Jessica Yoon,Anowara Islam,Aya Uchida,ChihKai Chang,Jo Anne Stratton,R. Wilder Scott,Fabio M.V. Rossi,T. Michael Underhill,Jeff Biernaskie,Jeff Biernaskie +20 more
TL;DR: It is shown that hair follicle mesenchymal progenitors make limited contributions to wound repair, and pharmacological modulation of RUNX1 and retinoic acid signaling or genetic deletion of Hic1 within wound-activated fibroblasts was sufficient to modulate healing outcomes, suggesting that reparative fibro Blasts have latent but modifiable regenerative capacity.
Journal ArticleDOI
Chlamydia muridarum T-Cell Antigens Formulated with the Adjuvant DDA/TDB Induce Immunity against Infection That Correlates with a High Frequency of Gamma Interferon (IFN-γ)/Tumor Necrosis Factor Alpha and IFN-γ/Interleukin-17 Double-Positive CD4+ T Cells
Hong Yu,Xiaozhou Jiang,Caixia Shen,Karuna P. Karunakaran,Janina Jiang,Nicole L. Rosin,Robert C. Brunham +6 more
TL;DR: A Chlamydia vaccine based on the recombinant proteins PmpG-1, PmpE/F-2, and MOMP delivered in a DDA/TDB adjuvant conferred protection against infection that correlated with IFN-γ/TNF-α and IFN -γ/IL-17 double-positive CD4+ T cells.