N
Niels Voigt
Researcher at University of Göttingen
Publications - 131
Citations - 7369
Niels Voigt is an academic researcher from University of Göttingen. The author has contributed to research in topics: Atrial fibrillation & Ryanodine receptor. The author has an hindex of 37, co-authored 117 publications receiving 6219 citations. Previous affiliations of Niels Voigt include University of Duisburg-Essen & Dresden University of Technology.
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Journal ArticleDOI
Calcium dysregulation in atrial fibrillation: the role of CaMKII.
TL;DR: The Ca2-handling derangements occurring in AF are summarized and the role of the multifunctional Ca2+/calmodulin-dependent protein kinase type-II (CaMKII), which acts as a major link between Ca2+.-dysregulation and arrhythmogenesis is focused on.
Journal ArticleDOI
Ca2+-Related Signaling and Protein Phosphorylation Abnormalities Play Central Roles in a New Experimental Model of Electrical Storm
Yukiomi Tsuji,Mayumi Hojo,Niels Voigt,Ali El-Armouche,Yasuya Inden,Toyoaki Murohara,Dobromir Dobrev,Stanley Nattel,Itsuo Kodama,Kaichiro Kamiya +9 more
TL;DR: ES causes Ca2+/calmodulin-dependent protein kinase II activation and phospholamban dephosphorylation, which can explain the vicious cycle of arrhythmia promotion and mechanical dysfunction that characterizes ES.
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Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation
Niels Voigt,Nadiia Rozmaritsa,Anne Trausch,Thomasz Zimniak,Torsten Christ,Erich Wettwer,Klaus Matschke,Dobromir Dobrev,Ursula Ravens +8 more
TL;DR: It is concluded that in cAF, flecainide and AVE0118 reduce receptor-independent, constitutively active IK,ACh, suggesting that they may block IK-ACh channels, whereas propafenone and dofetilide likely inhibit M-receptors.
Journal ArticleDOI
Impaired Local Regulation of Ryanodine Receptor Type-2 by Protein Phosphatase 1 Promotes Atrial Fibrillation
David Y. Chiang,Na Li,Qiongling Wang,Katherina M. Alsina,Ann P. Quick,Julia O. Reynolds,Guoliang Wang,Darlene G. Skapura,Niels Voigt,Dobromir Dobrev,Xander H.T. Wehrens +10 more
TL;DR: Decreased local PP1 regulation of RyR2 contributes toRyR2 hyperactivity and promotes AF susceptibility, which represents a novel mechanism for subcellular modulation of calcium channels and may represent a potential drug target of AF.
Journal ArticleDOI
Dysfunction in the βII Spectrin–Dependent Cytoskeleton Underlies Human Arrhythmia
Sakima A. Smith,Amy C. Sturm,Jerry Curran,Crystal F. Kline,Sean C. Little,Ingrid M. Bonilla,Victor P. Long,Michael A. Makara,Iuliia Polina,Langston D. Hughes,Tyler R. Webb,Zhiyi Wei,Zhiyi Wei,Patrick Wright,Niels Voigt,Deepak Bhakta,Katherine G. Spoonamore,Chuansheng Zhang,Raul Weiss,Philip F. Binkley,Paul M. Janssen,Ahmet Kilic,Robert S.D. Higgins,Mingzhai Sun,Jianjie Ma,Dobromir Dobrev,Mingjie Zhang,Cynthia A. Carnes,Matteo Vatta,Matthew N. Rasband,Thomas J. Hund,Peter J. Mohler +31 more
TL;DR: In this article, the authors uncover a new mechanism for the regulation of cardiac membrane excitability, which is essential for the posttranslational targeting and localization of critical membrane proteins in heart.