N
Niels Voigt
Researcher at University of Göttingen
Publications - 131
Citations - 7369
Niels Voigt is an academic researcher from University of Göttingen. The author has contributed to research in topics: Atrial fibrillation & Ryanodine receptor. The author has an hindex of 37, co-authored 117 publications receiving 6219 citations. Previous affiliations of Niels Voigt include University of Duisburg-Essen & Dresden University of Technology.
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Journal ArticleDOI
Upregulation of K(2P)3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation.
Constanze Schmidt,Felix Wiedmann,Niels Voigt,Xiaobo Zhou,Jordi Heijman,Siegfried Lang,Virginia Albert,Stefan Kallenberger,Arjang Ruhparwar,Gábor Szabó,Klaus Kallenbach,Matthias Karck,Martin Borggrefe,Peter Biliczki,Joachim R. Ehrlich,István Baczkó,Patrick Lugenbiel,Patrick A. Schweizer,Birgit C. Donner,Hugo A. Katus,Dobromir Dobrev,Dierk Thomas +21 more
TL;DR: The results highlight the potential of K2P3.1 as a novel drug target for mechanism-based AF therapy and contribute to APD shortening in patients with chronic AF, and reverses AF-related APDShortening.
Journal ArticleDOI
Transverse tubules are a common feature in large mammalian atrial myocytes including human
Mark A. Richards,Jessica D. Clarke,Palaniappan Saravanan,Niels Voigt,Dobromir Dobrev,David A. Eisner,Andrew W. Trafford,Katharine M. Dibb +7 more
TL;DR: The presence of t tubules in the human atria may play an important role in determining the spatio-temporal properties of the systolic Ca(2+) transient and how this is perturbed in disease.
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Inhibition of CaMKII Phosphorylation of RyR2 Prevents Induction of Atrial Fibrillation in FKBP12.6 Knockout Mice
Na Li,Tiannan Wang,Wei Wang,Michael J. Cutler,Qiongling Wang,Niels Voigt,David S. Rosenbaum,Dobromir Dobrev,Xander H.T. Wehrens +8 more
TL;DR: Genetic inhibition of RyR2-S2814 phosphorylation prevents AF induction in FKBP12.6−/− mice by suppressing SR Ca2+ leak and DADs, which promote triggered activity.
Journal ArticleDOI
Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation.
Niels Voigt,Adina Friedrich,Manja Bock,Erich Wettwer,Torsten Christ,Michael Knaut,Ruth H. Strasser,Ursula Ravens,Dobromir Dobrev +8 more
TL;DR: In cAF, the higher protein level of PKCepsilon but not PKCalpha, PKCbeta1 or PKCdelta is likely to contribute to the constitutive IK,ACh activity, while selective drug targeting of constitutively active IK-ACh channels may be suitable to reduce the ability of AF to become sustained.
Journal ArticleDOI
Multiple Potential Molecular Contributors to Atrial Hypocontractility Caused by Atrial Tachycardia Remodeling in Dogs
Reza Wakili,Yung-Hsin Yeh,Xiao Yan Qi,Maura Greiser,Denis Chartier,Kunihiro Nishida,Ange Maguy,Louis-Robert Villeneuve,Peter Boknik,Niels Voigt,Judith Krysiak,Stefan Kääb,Ursula Ravens,Wolfgang A. Linke,Gerrit J.M. Stienen,Yanfen Shi,Jean-Claude Tardif,Ulrich Schotten,Dobromir Dobrev,Stanley Nattel +19 more
TL;DR: The complex mechanistic basis of the atrial hypocontractility associated with AF argues for upstream therapeutic targeting rather than interventions directed toward specific downstream pathophysiological derangements.