N
Niels Voigt
Researcher at University of Göttingen
Publications - 131
Citations - 7369
Niels Voigt is an academic researcher from University of Göttingen. The author has contributed to research in topics: Atrial fibrillation & Ryanodine receptor. The author has an hindex of 37, co-authored 117 publications receiving 6219 citations. Previous affiliations of Niels Voigt include University of Duisburg-Essen & Dresden University of Technology.
Papers
More filters
Journal ArticleDOI
Human Atrial Action Potential and Ca2+ Model: Sinus Rhythm and Chronic Atrial Fibrillation
Eleonora Grandi,Sandeep V. Pandit,Niels Voigt,Antony J. Workman,Dobromir Dobrev,José Jalife,Donald M. Bers +6 more
TL;DR: In this article, the authors developed a new human atrial action potential (AP) model, derived from atrial experimental results and our human ventricular myocyte model, and showed how Na + and Ca 2+ homeostases critically mediate abnormal repolarization in AF.
Journal ArticleDOI
Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation.
Anil Purohit,Adam G. Rokita,Xiaoqun Guan,Biyi Chen,Olha M. Koval,Niels Voigt,Niels Voigt,Stefan Neef,Thomas Sowa,Zhan Gao,Elizabeth D. Luczak,Hrafnhildur Stefansdottir,Andrew C. Behunin,Na Li,Ramzi N. El-Accaoui,Baoli Yang,Paari Dominic Swaminathan,Robert M. Weiss,Xander H.T. Wehrens,Long-Sheng Song,Dobromir Dobrev,Dobromir Dobrev,Lars S. Maier,Mark E. Anderson,Mark E. Anderson +24 more
TL;DR: CaMKII is a molecular signal that couples increased reactive oxygen species with AF and that therapeutic strategies to decrease oxidized CaMKII may prevent or reduce AF.
Journal ArticleDOI
Transient Receptor Potential Canonical-3 Channel–Dependent Fibroblast Regulation in Atrial Fibrillation
Masahide Harada,Xiaobin Luo,Xiao Yan Qi,Artavazd Tadevosyan,Ange Maguy,Balázs Ördög,Jonathan Ledoux,Takeshi Kato,Patrice Naud,Niels Voigt,Yanfen Shi,Kaichiro Kamiya,Toyoaki Murohara,Itsuo Kodama,Jean-Claude Tardif,Ulrich Schotten,David R. Van Wagoner,Dobromir Dobrev,Stanley Nattel +18 more
TL;DR: TRPC3 channels regulate cardiac fibroblast proliferation and differentiation, likely by controlling the Ca2+ influx that activates extracellular signal-regulated kinase signaling and is a novel potential therapeutic target.
Journal ArticleDOI
MicroRNA29: A Mechanistic Contributor and Potential Biomarker in Atrial Fibrillation
Kristin Dawson,Reza Wakili,Balázs Ördög,Sebastian Clauss,Yu Chen,Yu-ki Iwasaki,Niels Voigt,Xiao Yan Qi,Moritz F. Sinner,Dobromir Dobrev,Stefan Kääb,Stanley Nattel +11 more
TL;DR: MiR29 likely plays a role in atrial fibrotic remodeling and may have value as a biomarker and/or therapeutic target and in a CHF-related AF animal model.
Journal ArticleDOI
Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation.
Niels Voigt,Anne Trausch,Michael Knaut,Klaus Matschke,András Varró,David R. Van Wagoner,Stanley Nattel,Ursula Ravens,Dobromir Dobrev +8 more
TL;DR: The hypothesis that a left-to-right gradient in inward rectifier background current contributes to high-frequency sources in LA that maintain atrial fibrillation is supported and has potentially important implications for development of atrial-selective therapeutic approaches.