N
Nizar Serhan
Researcher at University of Toulouse
Publications - 19
Citations - 1025
Nizar Serhan is an academic researcher from University of Toulouse. The author has contributed to research in topics: Myeloid leukemia & Reverse cholesterol transport. The author has an hindex of 11, co-authored 19 publications receiving 711 citations. Previous affiliations of Nizar Serhan include Université Bordeaux Segalen & Centre national de la recherche scientifique.
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Journal ArticleDOI
Chemotherapy Resistant Human Acute Myeloid Leukemia Cells are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
Thomas Farge,Thomas Farge,Estelle Saland,Estelle Saland,Fabienne De Toni,Fabienne De Toni,Nesrine Aroua,Nesrine Aroua,Moshen Hosseini,Moshen Hosseini,Robin L. Perry,Claudie Bosc,Claudie Bosc,Mayumi Sugita,Lucille Stuani,Lucille Stuani,Marine Fraisse,Marine Fraisse,Sarah J. Scotland,Sarah J. Scotland,Clément Larrue,Clément Larrue,Héléna Boutzen,Héléna Boutzen,Virginie Féliu,Virginie Féliu,Virginie Féliu,Marie-Laure Nicolau-Travers,Marie-Laure Nicolau-Travers,Stéphanie Cassant-Sourdy,Nicolas Broin,Nicolas Broin,Marion David,Marion David,Nizar Serhan,Nizar Serhan,Audrey Sarry,Suzanne Tavitian,Tony Kaoma,Laurent Vallar,Jason S. Iacovoni,Laetitia K. Linares,Laetitia K. Linares,Camille Montersino,Rémy Castellano,Emmanuel Griessinger,Yves Collette,Olivier Duchamp,Y Barreira,Pierre Hirsch,Tony Lionel Palama,Tony Lionel Palama,Tony Lionel Palama,Lara Gales,Lara Gales,Lara Gales,François Delhommeau,Barbara Garmy-Susini,Jean-Charles Portais,Jean-Charles Portais,Jean-Charles Portais,François Vergez,François Vergez,Mary A. Selak,Gwenn Danet-Desnoyers,Martin Carroll,Christian Recher,Jean-Emmanuel Sarry +67 more
TL;DR: It is demonstrated that essential mitochondrial functions contribute to AraC resistance in AML and are a robust hallmark of AraC sensitivity and a promising therapeutic avenue to treat AML residual disease.
Journal ArticleDOI
P2Y13 receptor is critical for reverse cholesterol transport.
Aurélie C.S. Fabre,Aurélie C.S. Fabre,Camille Malaval,Camille Malaval,Abduelhakem Ben Addi,Céline Verdier,Céline Verdier,Véronique Pons,Véronique Pons,Nizar Serhan,Nizar Serhan,Laeticia Lichtenstein,Laeticia Lichtenstein,Guillaume Combes,Guillaume Combes,Thierry Huby,François Briand,Xavier Collet,Xavier Collet,Niels Nijstad,Uwe J. F. Tietge,Bernard Robaye,Bertrand Perret,Bertrand Perret,Jean-Marie Boeynaems,Laurent O. Martinez,Laurent O. Martinez +26 more
TL;DR: These results establish P2Y13 as an attractive novel target for modulating RCT and support the emerging view that steady‐state plasma HDL levels do not necessarily reflect the capacity of HDL to promote RCT.
Journal ArticleDOI
Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor.
Maud Voisin,Philippe de Medina,Arnaud Mallinger,Florence Dalenc,Emilie Huc-Claustre,Julie Leignadier,Nizar Serhan,Regis Soules,Gregory Segala,Aurélie Mougel,Emmanuel Noguer,Loubna Mhamdi,Elodie Bacquié,Luigi Iuliano,Chiara Zerbinati,Magali Lacroix-Triki,Léonor Chaltiel,Thomas Filleron,Vincent Cavaillès,Talal Al Saati,Philippe Rochaix,Raphaëlle Duprez-Paumier,Camille Franchet,Laetitia Ligat,Frédéric Lopez,Michel Record,Marc Poirot,Sandrine Silvente-Poirot +27 more
TL;DR: The analysis of several human BC mRNA databases indicated that 11βHSD2 and ChEH overexpression correlated with a higher risk of patient death, highlighting that the biosynthetic pathway producing OCDO is of major importance to BC pathology.
Journal ArticleDOI
Dendrogenin A drives LXR to trigger lethal autophagy in cancers.
Gregory Segala,Gregory Segala,Marion David,Philippe de Medina,Mathias C. Poirot,Nizar Serhan,François Vergez,Aurélie Mougel,Estelle Saland,Kevin Carayon,Julie Leignadier,Nicolas Caron,Maud Voisin,Julia Cherier,Laetitia Ligat,Frédéric Lopez,Emmanuel Noguer,Arnaud Rives,Bruno Payré,Talal Al Saati,Antonin Lamaziere,Gaëtan Despres,Jean-Marc A. Lobaccaro,Silvère Baron,Cécile Demur,Fabienne De Toni,Clément Larrue,Héléna Boutzen,Fabienne Thomas,Jean-Emmanuel Sarry,Marie Tosolini,Didier Picard,Michel Record,Christian Recher,Marc Poirot,Sandrine Silvente-Poirot +35 more
TL;DR: Dendrogenin A can induce autophagy-mediated cell death in both melanoma and acute myeloid leukaemia, and this study reveals that DDA can direct control a nuclear receptor to trigger lethal Autophagy in cancers.
Journal ArticleDOI
Antileukemic Activity of 2-Deoxy-d-Glucose through Inhibition of N-Linked Glycosylation in Acute Myeloid Leukemia with FLT3-ITD or c-KIT Mutations
Clément Larrue,Clément Larrue,Estelle Saland,Estelle Saland,François Vergez,François Vergez,Nizar Serhan,Nizar Serhan,Eric Delabesse,Eric Delabesse,Véronique Mansat-De Mas,Véronique Mansat-De Mas,Jerome Tamburini,Jerome Tamburini,Stéphane Manenti,Stéphane Manenti,Jean-Emmanuel Sarry,Jean-Emmanuel Sarry,Christian Recher,Christian Recher +19 more
TL;DR: 2-DG displays a significant antileukemic activity in AML with FLT3-ITD or KIT mutations, opening a new therapeutic window in a subset of AMl with mutated RTKs.