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Nobuhito Taniki
Researcher at Keio University
Publications - 41
Citations - 764
Nobuhito Taniki is an academic researcher from Keio University. The author has contributed to research in topics: Medicine & Liver injury. The author has an hindex of 9, co-authored 31 publications receiving 382 citations.
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Journal ArticleDOI
Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis
Nobuhiro Nakamoto,Nobuo Sasaki,Nobuo Sasaki,Ryo Aoki,Ryo Aoki,Kentaro Miyamoto,Wataru Suda,Wataru Suda,Toshiaki Teratani,Takahiro Suzuki,Yuzo Koda,Yuzo Koda,Po Sung Chu,Nobuhito Taniki,Akihiro Yamaguchi,Mitsuhiro Kanamori,Nobuhiko Kamada,Masahira Hattori,Masahira Hattori,Hiroshi Ashida,Michiie Sakamoto,Koji Atarashi,Seiko Narushima,Akihiko Yoshimura,Kenya Honda,Toshiro Sato,Takanori Kanai,Takanori Kanai +27 more
TL;DR: Klebsiella pneumoniae from the gut microbiota of patients with primary sclerosing cholangitis can damage the intestinal epithelial barrier, resulting in bacterial translocation and T helper 17 cell responses in the liver, indicating a role in PSC pathogenesis.
Journal ArticleDOI
The liver-brain-gut neural arc maintains the Treg cell niche in the gut.
Toshiaki Teratani,Yohei Mikami,Nobuhiro Nakamoto,Takahiro Suzuki,Yosuke Harada,Koji Okabayashi,Yuya Hagihara,Nobuhito Taniki,Keita Kohno,Shinsuke Shibata,Kentaro Miyamoto,Harumichi Ishigame,Po Sung Chu,Tomohisa Sujino,Wataru Suda,Masahira Hattori,Minoru Matsui,Takaharu Okada,Hideyuki Okano,Masayuki Inoue,Toshihiko Yada,Yuko Kitagawa,Akihiko Yoshimura,Mamoru Tanida,Makoto Tsuda,Yusaku Iwasaki,Takanori Kanai,Takanori Kanai +27 more
TL;DR: It is demonstrated that the novel vago-vagal liver-brain-gut reflex arc tunes the number of pTreg cells and maintains the gut homeostasis, which could help develop new therapeutic strategies to treat or prevent immunological disorders of the gut.
Journal ArticleDOI
Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice.
Nobuhiro Nakamoto,Takeru Amiya,Takeru Amiya,Ryo Aoki,Ryo Aoki,Nobuhito Taniki,Yuzo Koda,Yuzo Koda,Kentaro Miyamoto,Toshiaki Teratani,Takahiro Suzuki,Sayako Chiba,Po Sung Chu,Atsushi Hayashi,Akihiro Yamaguchi,Shunsuke Shiba,Rei Miyake,Tadashi Katayama,Wataru Suda,Wataru Suda,Yohei Mikami,Nobuhiko Kamada,Hirotoshi Ebinuma,Hidetsugu Saito,Masahira Hattori,Masahira Hattori,Takanori Kanai +26 more
TL;DR: It is found that recruitment of immune-regulatory classical dendritic cells (cDCs) is crucial for liver tolerance in concanavalin A-induced acute liver injury and that beneficial gut microbes influence tolerogenic immune responses in the liver.
Journal ArticleDOI
CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells
Yuzo Koda,Yuzo Koda,Toshiaki Teratani,Po Sung Chu,Yuya Hagihara,Yohei Mikami,Yosuke Harada,Hanako Tsujikawa,Kentaro Miyamoto,Takahiro Suzuki,Nobuhito Taniki,Tomohisa Sujino,Michiie Sakamoto,Takanori Kanai,Takanori Kanai,Nobuhiro Nakamoto +15 more
TL;DR: In this article, using a murine diet-induced NASH and the subsequent resolution model, the authors demonstrate direct roles of CD8+ tissue-resident memory CD8+, T (CD8+ Trm) cells in resolving liver fibrosis.
Journal ArticleDOI
On-treatment decrease of NKG2D correlates to early emergence of clinically evident hepatocellular carcinoma after interferon-free therapy for chronic hepatitis C
Po Sung Chu,Nobuhiro Nakamoto,Nobuhito Taniki,Keisuke Ojiro,Takeru Amiya,Yuko Makita,Yuko Makita,Hiroko Murata,Akihiro Yamaguchi,Shunsuke Shiba,Rei Miyake,Tadashi Katayama,Aya Ugamura,Akihiko Ikura,Karin Takeda,Hirotoshi Ebinuma,Hirotoshi Ebinuma,Hidetsugu Saito,Takanori Kanai +18 more
TL;DR: Higher pre-treatment NKG2D expression, higher FIB-4 score, previous HCC history and failure to achieve sustained viral response were significant factors correlating to early HCC emergence.