O
Olga Kifor
Researcher at Brigham and Women's Hospital
Publications - 68
Citations - 11596
Olga Kifor is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Calcium-sensing receptor & Parathyroid chief cell. The author has an hindex of 51, co-authored 68 publications receiving 11241 citations. Previous affiliations of Olga Kifor include Harvard University & University of Picardie Jules Verne.
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Journal ArticleDOI
Cloning and characterization of an extracellular Ca 2+ -sensing receptor from bovine parathyroid
Edward M. Brown,Gerardo Gamba,Daniela Riccardi,Michael Lombardi,Robert Butters,Olga Kifor,Adam Sun,Adam Sun,Matthias A. Hediger,Jonathan Lytton,Steven C. Hebert +10 more
TL;DR: The cloning of complementary DNA encoding an extracellular Ca2+ -sensing receptor from bovine parathyroid is reported with pharmacological and functional properties nearly identical to those of the native receptor.
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Autosomal dominant hypocalcaemia caused by a Ca 2+ -sensing receptor gene mutation
Martin R. Pollak,Edward M. Brown,Herschel L. Estep,Peter N. McLaine,Olga Kifor,Ji Park,Steven C. Hebert,Christine E. Seidman,Jonathan G. Seidman +8 more
TL;DR: It is demonstrated that a missense mutation (Glu128Ala) in this gene causes familial hypocalcaemia in affected members of one family, and this extracellular domain mutation increases the receptor's activity at low Ca2+ concentrations, causing hypocalcemia in patients heterozygous for such a mutation.
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A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
Chrystal Ho,David A. Conner,Martin R. Pollak,Martin R. Pollak,Daniel Ladd,Daniel Ladd,Olga Kifor,Henry B. Warren,Edward M. Brown,Jonathan G. Seidman,Christine E. Seidman +10 more
TL;DR: The findings suggest that Casr mutations cause these human disorders by reducing the number of functional receptor molecules on the cell surface.
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A Familial Syndrome of Hypocalcemia with Hypercalciuria Due to Mutations in the Calcium-Sensing Receptor
Simon H. S. Pearce,Catherine Williamson,Olga Kifor,Mei Bai,Malcolm G. Coulthard,Michael Davies,Nicholas Lewis-Barned,David A. McCredie,Harley R. Powell,Pat Kendall-Taylor,Edward M. Brown,Rajesh V. Thakker +11 more
TL;DR: Gain-of-function mutations in the calcium-sensing receptor are associated with a familial syndrome of hypocalcemia with hypercalciuria that needs to be distinguished from hypoparathyroidism.
Journal ArticleDOI
Reduced immunostaining for the extracellular Ca2+-sensing receptor in primary and uremic secondary hyperparathyroidism.
Olga Kifor,Francis D. Moore,Ping H. Wang,M Goldstein,Peter M. Vassilev,Imre Kifor,Steven C. Hebert,Edward M. Brown +7 more
TL;DR: There is a variable, but substantial, reduction in the immunoreactivity of the Ca2+o-sensing receptor protein in both parathyroid adenomas and uremic hyperparathyroidism, as assessed by immunohistochemistry, that probably results from reduced expression of the receptor protein and may contribute to the increase in the set-point often observed in these patients.