M
Mustafa T. Ardah
Researcher at United Arab Emirates University
Publications - 34
Citations - 2617
Mustafa T. Ardah is an academic researcher from United Arab Emirates University. The author has contributed to research in topics: Dopaminergic & Substantia nigra. The author has an hindex of 18, co-authored 31 publications receiving 2063 citations.
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Journal ArticleDOI
α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.
Bruno Fauvet,Martial K. Mbefo,Mohamed Bilal Fares,Carole Desobry,Sarah Michael,Mustafa T. Ardah,Elpida Tsika,Philippe Coune,Michel Prudent,Niels Lion,David Eliezer,Darren J. Moore,Bernard L. Schneider,Patrick Aebischer,Omar M. A. El-Agnaf,Eliezer Masliah,Hilal A. Lashuel +16 more
TL;DR: Wang et al. as discussed by the authors investigated the oligomeric state of α-syn in mouse, rat, and human brains and showed that both human and rodent αsyn expressed in the central nervous system exist predominantly as an unfolded monomer.
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Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease
Takahiko Tokuda,Mohamed M. Qureshi,Mustafa T. Ardah,Shiji Varghese,Safa Shehab,Takashi Kasai,Noriko Ishigami,Akira Tamaoka,Masanori Nakagawa,Omar M. A. El-Agnaf +9 more
TL;DR: It is demonstrated that levels of α-synuclein oligomers in CSF and the oligomers/total-α- synuclein ratio can be useful biomarkers for diagnosis and early detection of PD.
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Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
Nour K. Majbour,Nour K. Majbour,Nishant N. Vaikath,Nishant N. Vaikath,Karin van Dijk,Mustafa T. Ardah,Shiji Varghese,Louise Buur Vesterager,Liliana P. Montezinho,Stephen Poole,Bared Safieh-Garabedian,Takahiko Tokuda,Charlotte E. Teunissen,Henk W. Berendse,Wilma D.J. van de Berg,Omar M. A. El-Agnaf +15 more
TL;DR: The combination of CSF o-/t- α-syn, p-S129-α-syn and p-tau provided the best fitting predictive model for discriminating PD patients from controls and correlated significantly with the severity of PD motor symptoms.
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Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias†‡
Lucilla Parnetti,Davide Chiasserini,Gianni Bellomo,David Giannandrea,Claudia De Carlo,Mohamed M. Qureshi,Mustafa T. Ardah,Shiji Varghese,Laura Bonanni,Barbara Borroni,Nicola Tambasco,Paolo Eusebi,Aroldo Rossi,Marco Onofrj,Alessandro Padovani,Paolo Calabresi,Omar M. A. El-Agnaf +16 more
TL;DR: Combined determination of α‐synuclein and classical biomarkers in cerebrospinal fluid shows differential patterns in neurodegenerative disorders, and total tau/α‐syn nuclein and phosphorylated tau /α‐ synuclein ratios can contribute to the discrimination of Parkinson's disease.
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Baicalein Inhibits Formation of α-Synuclein Oligomers within Living Cells and Prevents Aβ Peptide Fibrillation and Oligomerisation
Jia-Hong Lu,Mustafa T. Ardah,Siva Sundara Kumar Durairajan,Liang-Feng Liu,Li-Xia Xie,Wang-Fun Fong,Mohamed Y. Hasan,Jian-Dong Huang,Omar M. A. El-Agnaf,Min Li +9 more
TL;DR: Zhang et al. as discussed by the authors showed that Baicalein, a flavonoid extracted from the Chinese herbal medicine Scutellaria baicalensis Georgi ("huang qin" in Chinese), is a potent inhibitor of α-syn oligomerization both in cell-free and cellular systems.